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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:37 PM IST
Glocarbazin 50mg Tablet is an anti-cancer medicine used in the treatment of Hodgkin's lymphoma and certain brain tumors. This medicine works by inhibiting the proteins and DNA necessary for cell growth and division, thereby reducing the further growth of cancerous cells. Common side effects include nausea, vomiting, bruising, cramps, rash and loss of appetite.
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Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Glocarbazin 50mg Tablet

Glocarbazin 50mg Tablet belongs to the group of anti-cancer drugs and chemotherapeutic agents. Glocarbazin 50mg Tablet is used to treat cancers and malignant conditions such as Hodgkin’s disease (cancer that originates in the white blood cells) and certain brain tumours.

Glocarbazin 50mg Tablet contains ‘’Procarbazine.’’ Cancer is an uncontrolled growth of cells in the body. Glocarbazin 50mg Tablet interferes with the growth of cells, nipping it in the bud. It functions by inhibiting the molecular production of materials such as proteins and DNA necessary for cell growth and division.

Glocarbazin 50mg Tablet is a prescription-only medicine. It may be taken as a tablet at the same time every day. Glocarbazin 50mg Tablet may be taken with or without food. It should be swallowed as a whole and not chewed or broken down. Avoid consuming Glocarbazin 50mg Tablet with certain foods like cheese, smoked fish, fermented wine and meat.

In some cases, Glocarbazin 50mg Tablet may cause common side effects such as nausea, vomiting, bruising, cramps, rash and loss of appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

It is advisable to inform your doctor if you are allergic to Glocarbazin 50mg Tablet or any of its components. Keep your doctor informed if you suffer from kidney or liver disease, bleeding problems, anaemia or recurrent infections. Keep your doctor informed if you are on any radiation therapy. Consult your doctor if you are pregnant, planning pregnancy or breastfeeding before taking Glocarbazin 50mg Tablet as Glocarbazin 50mg Tablet is not recommended for routine use in these states. Consult your doctor before taking alcohol with Glocarbazin 50mg Tablet as there may be an interaction. Avoid smoking while taking Glocarbazin 50mg Tablet.

Uses of Glocarbazin 50mg Tablet

Treatment of Hodgkin's Lymphoma.

Medicinal Benefits

Glocarbazin 50mg Tablet is an antineoplastic/anti-cancer drug. It contains PROCARBAZINE. It is used primarily in the treatment of cancers, especially Hodgkin’s lymphoma. Glocarbazin 50mg Tablet shows antineoplastic activity, meaning it targets neoplastic (abnormally growing cells) in the body and inhibits their uncontrolled division and growth. Glocarbazin 50mg Tablet works by preventing DNA, RNA and protein synthesis required for the molecular development of cells. Glocarbazin 50mg Tablet also acts by destroying DNA, thereby arresting cell growth in the roots. Hence, Glocarbazin 50mg Tablet is very effective in cancer therapy.

Directions for Use

Take Glocarbazin 50mg Tablet as directed by the physician. Glocarbazin 50mg Tablet should be swallowed as a whole. Do not crush, chew or break it. Glocarbazin 50mg Tablet can be taken with or without food, but it is better to take it with food. Avoid tyramine-rich foods such as processed cheese, smoked fish and meats, overripe fruit, fermented wine and non-alcoholic beer with Glocarbazin 50mg Tablet intake. In case you have missed a dose, take it as soon as you remember unless it is too close to the time of the second dose. Do not take a double dose in any case. Do not stop taking Glocarbazin 50mg Tablet abruptly and/or without the supervision of your physician.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Glocarbazin 50mg Tablet

  • Vomiting
  • Nausea
  • Stomach cramps
  • Rash             
  • Bruising
  • Loss of appetite
  • Hair loss
  • Joint pains
  • Difficulty sleeping

Drug Warnings

Glocarbazin 50mg Tablet should not be used in case of any known allergy to either of the components. Avoid foods such as processed cheese, smoked fish, meats, overripe fruit, fermented wine, and yeast while taking Glocarbazin 50mg Tablet. Glocarbazin 50mg Tablet should be used with caution in case of high-risk or previous history cancers, cardiovascular health disorders, bleeding disorders, kidney disease, liver disease or anaemia. Keep your doctor informed of your medical history and if you suffer from epilepsy, an adrenal tumour such as phaeochromocytoma, or have had a stroke. Consult your doctor before using Glocarbazin 50mg Tablet during pregnancy, breastfeeding, or even if you are trying to get pregnant. Keep your doctor informed if you are on painkillers or using any nasal decongestants or anti-anxiety, anti-depressant, antiepileptic, anaesthetic or analgesic medications. Keep your doctor informed in case you are undergoing any radiation therapy. Inform your doctor of your vaccination history and do not take any vaccines without consent. Avoid contact with those who have recently received live vaccines (like the nasal flu, pox, or MMR vaccine). Glocarbazin 50mg Tablet makes your skin more sensitive to UV radiation. Wear sunscreen and protective clothing while venturing out in the sun. Glocarbazin 50mg Tablet may interact with alcohol, please consult your doctor before use. Glocarbazin 50mg Tablet may cause dizziness and is not recommended to take while driving or operating heavy machinery.

Drug Interactions

Drug-Drug Interactions: Glocarbazin 50mg Tablet may interact with painkillers (pethidine), ADHD medicines (atomoxetine, bupropion, buspirone), anti-migraine drugs (triptans), narcotics (methadone, tapentadol), certain supplements (such as tryptophan, tyramine), certain drugs for Parkinson's disease (entacapone, levodopa, tolcapone), diet-pills and food suppressants (diethylpropion), antipsychotic (clozapine), antihypertensives (ramipril, enalapril, losartan), antiepileptics (phenytoin, carbamazepine) and anti-depressants (fluoxetine, duloxetine, venlafaxine, St John’s wort).

Drug-Food Interactions: Glocarbazin 50mg Tablet can interact with alcohol and tobacco.

Drug-Disease Interactions: Glocarbazin 50mg Tablet should be used with caution in patients with a known hypersensitivity disorder, asthma, diabetes mellitus, epilepsy, stroke, heart failure, liver disease, kidney disease, blood disorder, clotting problems and non-cancerous tumours such as phaeochromocytoma.

Drug-Drug Interactions Checker List

  • ATOMOXETINE
  • BUSPIRONE
  • SUMATRIPTAN
  • PETHIDINE
  • METHADONE
  • TAPENTADOL
  • TRYPTOPHAN
  • RAMIPRIL
  • ENALAPRIL
  • LOSARTAN
  • PHENYTOIN
  • CARBAMAZEPINE
  • CLOZAPINE
  • FLUOXETINE
  • DULOXETINE
  • ENTACAPONE
  • LEVODOPA

Habit Forming

No

Diet & Lifestyle Advise

  • Keep your doctor informed if you are planning to or are pregnant.

  • Cancer can take a toll on anyone. Make sure you regularly see a therapist and take care of your mental health.

  • Meditation and yoga have also proven very effective in helping cancer patients maintain a healthy attitude and body.

  • Cut back on foods that are high in tyramine such as overripe fruit, processed cheese, smoked fish, meat etc. Eat more healthy meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy.

  • Avoid taking Glocarbazin 50mg Tablet with alcohol as there may be an interaction.

  • Stay hydrated by drinking plenty of water as dehydration is often seen in cancers.

  • Taking a stroll in the garden, or spending 30 mins of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired.

  • Avoid tobacco use as smoking can increase the chances of lung cancer when used with Glocarbazin 50mg Tablet. Inform your doctor in case of marijuana use.

Special Advise

  • Take Glocarbazin 50mg Tablet exactly as prescribed. 

  • In case you miss a dose of Glocarbazin 50mg Tablet, take it as soon as possible. However, revert to the original schedule if it is too close to the next dose. Do not ever take a double dose.

  • Please inform your doctor immediately if you accidentally take an extra dose of Glocarbazin 50mg Tablet. Some common symptoms of an overdose can be low blood pressure, slow pulse, shortness of breath, low blood sugar, fits, dizziness, feeling sick and discolouration of the skin.

  •  Do not discontinue taking Glocarbazin 50mg Tablet abruptly or without the advice of the physician.

  • Please know that your doctor may order blood tests to check your tolerance and need of Glocarbazin 50mg Tablet.

  • Avoid getting out in the sun after taking Glocarbazin 50mg Tablet and if you do, make sure you use a potent sunscreen and wear protective clothing.

Disease/Condition Glossary

Hodgkin’s Disease: Hodgkin’s disease or lymphoma is a blood cancer of a certain type of cells called WBCs, specifically lymphocytes. Lymphocytes normally help control infection and maintain the body's normal immunity. However, in a cancerous state, there is an abnormal multiplication of these blood cells causing many problems such as fatigue, fever, loss of appetite, itching, night sweats and lymph node swelling.

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Alcohol

Unsafe

Do not consume alcohol with Glocarbazin 50mg Tablet as there may be an interaction, causing vomiting, cramps, sweating and flushing of the face. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Glocarbazin 50mg Tablet is not recommended for use in pregnancy. It is not safe during the first trimester. If you are pregnant, inform your doctor before taking Glocarbazin 50mg Tablet.

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Breast Feeding

Unsafe

Glocarbazin 50mg Tablet is not recommended for use during breastfeeding. Please consult your doctor if you have any concerns.

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Driving

Caution

Glocarbazin 50mg Tablet may cause dizziness or loss of alertness, which may affect your ability to drive.

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Liver

Caution

Glocarbazin 50mg Tablet is not recommended for use if you have pre-existing liver disease. Hence, please consult your doctor before taking this medicine.

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Kidney

Caution

Glocarbazin 50mg Tablet is not recommended for use if you have pre-existing kidney disease. Hence, please consult your doctor before taking this medicine.

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Children

Caution

Glocarbazin 50mg Tablet should be used with caution and only in prescribed doses in children below 12 years of age. Please consult your child's doctor if you have any concerns.

Country of origin

India
Other Info - GL52953

Author Details

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FAQs

Glocarbazin 50mg Tablet belongs to the group of anti-cancer drugs and chemotherapeutic agents. Glocarbazin 50mg Tablet is used to treat cancers and malignant conditions such as Hodgkins disease (cancer that originates in the white blood cells) and certain brain tumours.
Glocarbazin 50mg Tablet works by reducing the workload on the heart and vessels and relaxing the vessels to ensure a fluid flow of blood, easing any hypertension and effects of the same.
Please consult your physician before altering your chemotherapy as any misguided change can cause serious side effects. One of the side effects of Glocarbazin 50mg Tablet is also hair loss. Hence it is best to discuss your treatment plan with your doctor.
If you suffer from IBD, you may be on anticholinergic therapy which may interfere with Glocarbazin 50mg Tablet. Please consult your doctor before use and discuss any concerns with your doctor.
Glocarbazin 50mg Tablet is known to play a role in the treatment of various types of cancer, however, it is not routinely indicated in the treatment of breast cancer. Only proceed once a doctor has prescribed the same because the treatment for breast cancer is nuanced.
Glocarbazin 50mg Tablet is known to affect fertility. Avoid Glocarbazin 50mg Tablet if you are trying to get pregnant. Please consult your doctor in case of any concerns.

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