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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Glanikinase 1500000IU Injection is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis. Glanikinase 1500000IU Injection contains Streptokinase, which works by dissolving the harmful blood clots in the blood vessels; this restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

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Manufacturer/Marketer :

Gland Pharma Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Glanikinase 1500000IU Injection

Glanikinase 1500000IU Injection belongs to the class of medicines called antifibrinolytic agents. It is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis.

Glanikinase 1500000IU Injection contains Streptokinase. Streptokinase creates a highly specific 1:1 enzymatic complex with plasminogen that transforms inactive plasminogen molecules into active plasmin. Plasmin destroys fibrin clots, as well as fibrinogen and other plasma proteins. This, in turn, causes the breakdown of blood clots.

Glanikinase 1500000IU Injection should be administered to patients only in a hospital setting by an experienced healthcare professional. Glanikinase 1500000IU Injection may cause certain common side effects, including allergic reactions, hypotension, tachycardia, bradycardia, hypotension, heart rate and rhythm disorders, angina pectoris, nausea, diarrhoea, epigastric pain, vomiting, headache, back pain, musculoskeletal pain, chills, fever, asthenia, elevations of serum transaminases and bilirubin. These side effects usually go away on their own. If you develop any other serious side effects, such as vision problems while using Glanikinase 1500000IU Injection, consult your doctor immediately.

Glanikinase 1500000IU Injection is indicated in adults. Glanikinase 1500000IU Injection is not recommended for children below 18 years of age as the safety and effectiveness were not established. Inform your doctor if you are pregnant or planning for pregnancy or breastfeeding since Glanikinase 1500000IU Injection is contra-indicated in pregnancy, especially within the first 18 weeks of pregnancy. It is unknown whether Streptokinase is excreted in human milk. Breast milk should be discarded during the first 24 hours following thrombolytic therapy.

Uses of Glanikinase 1500000IU Injection

Used to dissolve blood clots that have formed in the blood vessels and Treatment of Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous, and Arterial thrombosis

Directions for Use

Glanikinase 1500000IU Injection will be given to you by your healthcare professional.

Medicinal Benefits

Glanikinase 1500000IU Injection contains ‘Streptokinase’, which belongs to the class of anti-fibrinolytic agents. It acts by regulating the breakdown of blood clots in the body. It blocks the release and action of plasmin, an enzyme essential for the breakdown of clots in the blood. This effect helps to slow down abnormal bleeding.

How Glanikinase 1500000IU Injection Works

Glanikinase 1500000IU Injection contains Streptokinase. Streptokinase creates a highly specific 1:1 enzymatic complex with plasminogen that transforms inactive plasminogen molecules into active plasmin. Plasmin destroys fibrin clots, as well as fibrinogen and other plasma proteins. This, in turn, causes the breakdown of blood clots.

Side Effects of Glanikinase 1500000IU Injection

  • Haemorrhage at the injection site
  • Ecchymoses (a discoloration of the skin)
  • Gastrointestinal bleeding
  • Genitourinary bleeding
  • Epistaxis (nosebleed)
  • Development of anti-streptokinase antibodies
  • Allergic reactions
  • Hypotension
  • Tachycardia
  • Bradycardia
  • Hypotension
  • Heart rate and rhythm disorders
  • Angina pectoris
  • Nausea
  • Diarrhoea
  • Epigastric pain
  • Vomiting
  • Headache
  • Back pain
  • Musculoskeletal pain
  • Chills
  • Fever
  • Asthenia (abnormal physical weakness)
  • Elevations of serum transaminases and bilirubin

What if I have taken an overdose of Glanikinase 1500000IU Injection

As Glanikinase 1500000IU Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Before taking Glanikinase 1500000IU Injection, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Usage of Glanikinase 1500000IU Injection contraindicated to use in persons with certain medical conditions that cause risk of bleeding such as existing or recent internal haemorrhage (internal bleeding), recent cerebrovascular accident, intracranial or intraspinal surgery, intracranial neoplasm (brain tumour), recent head trauma, arteriovenous malformation (an abnormal connection between arteries and veins), neoplasm  (a cancerous tumour) with risk of bleeding, pancreas inflammation, severe liver or kidney damage and simultaneous or recent treatment with oral anticoagulants. So, let your doctor know about all your medical conditions, sensitivities, and all medications you are using.

Drug-Drug Interactions

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StreptokinaseDalteparin
Severe
StreptokinaseApixaban
Severe

Drug-Drug Interactions

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StreptokinaseDalteparin
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Using Glanikinase 1500000IU Injection 1's together with dalteparin may increase the risk of bleeding.

How to manage the interaction:
Although taking Dalteparin with Glanikinase 1500000IU Injection 1's may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
StreptokinaseApixaban
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Coadministration of Glanikinase 1500000IU Injection 1's and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Glanikinase 1500000IU Injection 1's and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
StreptokinasePrasugrel
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Co-administration of Prasugrel with Glanikinase 1500000IU Injection 1's can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Glanikinase 1500000IU Injection 1's with Prasugrel can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
StreptokinaseIbrutinib
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Co-administration of Ibrutinib with Glanikinase 1500000IU Injection 1's can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrutinib with Glanikinase 1500000IU Injection 1's together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
StreptokinaseCangrelor
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Co-administration of Cangrelor with Glanikinase 1500000IU Injection 1's can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Glanikinase 1500000IU Injection 1's and Cangrelor, but it can be taken if prescribed by a doctor. However, consult doctor immediately if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not stop using any medications without talking to a doctor.
StreptokinaseDasatinib
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Coadministration of Dasatinib with Glanikinase 1500000IU Injection 1's can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Glanikinase 1500000IU Injection 1's with Dasatinib can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you experience bruising, dizziness; red or black, tarry stools; severe headache; and weakness. Do not discontinue any medications without consulting a doctor.
StreptokinaseWarfarin
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Coadministration of Warfarin with Glanikinase 1500000IU Injection 1's can increase the risk of bleeding.

How to manage the interaction:
Although taking Glanikinase 1500000IU Injection 1's and warfarin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
StreptokinaseDabigatran etexilate
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Taking Dabigatran etexilate with Glanikinase 1500000IU Injection 1's can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Glanikinase 1500000IU Injection 1's together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
StreptokinaseHeparin
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Taking Heparin with Glanikinase 1500000IU Injection 1's can increase the risk of bleeding.

How to manage the interaction:
Although taking Heparin and Glanikinase 1500000IU Injection 1's together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
StreptokinaseRivaroxaban
Severe
How does the drug interact with Glanikinase 1500000IU Injection 1's:
Co-administration of Glanikinase 1500000IU Injection 1's and Rivaroxaban can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Glanikinase 1500000IU Injection 1's and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Ask your doctor about the preferred exercises to do based on your health condition.
  • Stay hydrated and consume plenty of fluids. Fluids are necessary to maintain blood flow in your body.
  • Consume fresh fruits and vegetables. Consult a dietitian and prepare a diet plan. Eating healthy can help you to recover faster.

Habit Forming

No

Therapeutic Class

ANTIFIBRINOLYTIC AGENTS

Glanikinase 1500000IU Injection Substitute

Substitutes safety advice
  • Stpase 1500000Iu Injection

    2003.40per tablet
  • THROMBOFLUX 1500000IU INJECTION

    1921.50per tablet
  • STUKINASE 1500000IU INJECTION

    1849.80per tablet
  • Lupiflo 1500000 Injection

    1891.80per tablet
  • R-Thrombo 15,00,000 I.U Inj

    by AYUR

    1693.53per tablet
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Alcohol

Caution

Glanikinase 1500000IU Injection may not interact with alcohol. However, avoid the consumption of alcohol as it may worsen your health condition.

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Pregnancy

Caution

Glanikinase 1500000IU Injection is contra-indicated in pregnancy, especially within the first 18 weeks of pregnancy.

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Breast Feeding

Caution

It is unknown whether streptokinase is excreted in human milk. Breast milk should be discarded during the first 24 hours following thrombolytic therapy.

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Driving

Caution

It is not known whether Glanikinase 1500000IU Injection alters the ability to drive. Do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Inform your doctor before receiving Glanikinase 1500000IU Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Glanikinase 1500000IU Injection if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Unsafe

Glanikinase 1500000IU Injection is not recommended in neonates, infants and children.

FAQs

Glanikinase 1500000IU Injection is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis.
Glanikinase 1500000IU Injection contains Streptokinase. Streptokinase creates a highly specific 1:1 enzymatic complex with plasminogen that transforms inactive plasminogen molecules into active plasmin. Plasmin destroys fibrin clots, as well as fibrinogen and other plasma proteins. This, in turn, causes the breakdown of blood clots.
Glanikinase 1500000IU Injection may cause Arrhythmia. Arrhythmia monitoring is advised during and soon following delivery of Streptokinase.
The most frequent adverse reaction associated with this therapy is bleeding. In most cases, this condition gradually resolves over time. However, if bleeding persists, contact your doctor.
Do not take anticoagulants; drugs that inhibit platelet function increase the risk of bleeding when administered Glanikinase 1500000IU Injection.
Glanikinase 1500000IU Injection may cause side effects in some individuals. Commonly reported side effects include allergic reactions, fluctuations in blood pressure and heart rate, chest pain, gastrointestinal issues like nausea and diarrhea, muscle pain, headache, chills, fever, and general weakness. Additionally, it may occasionally affect liver function, leading to elevated serum transaminase and bilirubin levels. Most side effects are temporary and resolve without needing further treatment. However, if you experience severe side effects, such as vision problems, seek immediate medical attention for proper evaluation and guidance.

Country of origin

India

Manufacturer/Marketer address

201, Devavrata, Sector 17, Vashi, Navi Mumbai ? 400 703, India
Other Info - GLA0189

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