Do not take Duo 2 Eye Drop if you are allergic to any of its components, if you are taking monoamine oxidase inhibitors, antidepressants, if you have severe kidney problems or excess acidity in the blood. Inform your doctor if you have liver problems, narrow-angle glaucoma, dry eyes, cornea problems, coronary heart disease, depression, poor or disturbed blood circulation. Consult a doctor before using Duo 2 Eye Drop if you are pregnant or breastfeeding. Duo 2 Eye Drop is not recommended for children below 18 years as safety and effectiveness have not been established. Duo 2 Eye Drop might cause dizziness, drowsiness, abnormal/blurred vision; so, drive only if you are alert.