Domine 25mg/500mg Tablet is an antimalarial medicine used to treat malaria. Malaria is a parasitic disease caused by the Plasmodium species. The infection occurs when a mosquito bites and enters the human body. Domine 25mg/500mg Tablet is also used to treat toxoplasmosis (an infection caused by the parasite Toxoplasma gondii).

Domine 25mg/500mg Tablet contains Pyrimethamine and Sulphadoxine as active ingredients. Pyrimethamine kills the parasite and stops the infection from spreading. Sulphadoxine helps prevent the parasite from producing folinic acid, which is necessary for its multiplication.

Domine 25mg/500mg Tablet may cause certain side effects such as nausea, dizziness, vomiting, headache, diarrhoea, anorexia, body pain, and stomach discomfort. If these side effects persist, inform your doctor immediately. Domine 25mg/500mg Tablet should be taken as advised by your doctor.

Domine 25mg/500mg Tablet should be avoided if you are allergic to it or any other artemisinin derivatives. Before taking $ name, inform your doctor if you have/had any conditions such as anaemia, liver/kidney disease, heart problem, or are taking any other medicines, as it may cause serious side effects under these conditions. If you are pregnant or breastfeeding, inform your doctor before taking Domine 25mg/500mg Tablet.

Domine 25mg/500mg Tablet is a combination medicine containing Pyrimethamine and Sulphadoxine as active ingredients. Pyrimethamine works by increasing the harmful, toxic, and highly reactive free radicals in the blood. This kills the parasite and stops the infection from spreading. Sulphadoxine helps prevent the parasite from producing folinic acid, which is necessary for their multiplication. Domine 25mg/500mg Tablet is used to prevent the relapse of malaria caused by plasmodium species.

• Vomiting
• Headache
• Dizziness
• Abdominal pain
• Weakness
• Nausea
• Anorexia
• Tiredness

Avoid using Domine 25mg/500mg Tablet if you are allergic to it or any other artemisinin derivatives. Inform your doctor if you have/had any conditions such as liver/kidney disease, heart problems, or taking any other medicines before receiving Domine 25mg/500mg Tablet as it may cause serious side effects under these conditions. Domine 25mg/500mg Tablet is recommended for use in children only if prescribed by the paediatrician, and if administered, proper care and dosing should be checked. This medicine is contraindicated in patients with folic acid deficiency. It is advised not to use Domine 25mg/500mg Tablet for more than two years. Avoid driving and operating machines until you are alert.

Drug-Drug Interactions: Domine 25mg/500mg Tablet may interact with antacids and many other medicines. Hence, inform your doctor on priority.

Drug-Food Interactions: No interactions found. 

Drug-Disease Interactions: Domine 25mg/500mg Tablet should be used with caution in patients with severe liver and kidney failure, gastrointestinal system (gut), and heart problems.

• It is important to allow the patient to eat regularly in small amounts to tolerate the food. 
• Try to add protein to your diet for malaria-induced weight loss.
• Eating at the right time and getting proper rest is important for the patient to recover.
• Avoid eating fried and processed foods, and junk oily and spicy foods can aggravate nausea and disturb the body's digestion process.
• Eat nutritious food that helps to improve malaria-induced weakness.
• Keep your area and surroundings mosquito-free. Use mosquito-repellent products to avoid the recurrence of infections and any other further complications.

Malaria: It is a life-threatening parasitic disease caused by mosquito bites. When the mosquito bites, the plasmodium parasite enters the body, multiplies in the liver, spreads via the bloodstream and thus causes the infection by releasing toxic chemicals. Symptoms may include chills, on-and-off fever, sweating, vomiting, etc.

Toxoplasmosis: It is an infection caused by parasites toxoplasma gondii found in contaminated food and cat faeces. It can cause serious complications for pregnant women, such as miscarriage, stillbirths, and damage to the baby’s brain and other organs, particularly the eyes, at birth or early childhood, and people with weakened immune systems. Symptoms include muscle pain, fever, headache, etc.