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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Digitran 0.25mg Tablet is used to treat irregular heartbeats and manage the symptoms of heart failure. It contains Digoxin, which works on the heart muscle directly and increases the force with which the heart muscle contracts with each heartbeat. Thereby, it makes the heart efficient in pumping blood around the body and slows down the rate at which the heart beats. Some people may experience common side effects like diarrhoea, nausea, vomiting, dizziness, abnormal heartbeat or skin rash. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

DIGOXIN-0.25MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Digitran 0.25mg Tablet

Digitran 0.25mg Tablet is used to treat irregular heartbeats and manage the symptoms of heart failure. Heart failure is a chronic condition in which the heart is unable to pump blood as effectively as it should. Irregular heartbeat is a condition in which your heart beats irregularly, too fast or too slow.

Digitran 0.25mg Tablet contains digoxin, i.e. cardiac glycosides that help to increase the output force of the heart and reduce the rate of heart contractions. Digitran 0.25mg Tablet works on the heart muscle directly and increases the force with which the heart muscle contracts with each heartbeat. Thereby, it makes the heart efficient in pumping blood around the body and slows down the rate at which the heart beats.

Take Digitran 0.25mg Tablet as prescribed. Your doctor will recommend how often you take Digitran 0.25mg Tablet based on your medical condition. Some people may experience common side effects like diarrhoea, nausea, vomiting, dizziness, abnormal heartbeat or skin rash. Most of these side effects of Digitran 0.25mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are known to be allergic to Digitran 0.25mg Tablet or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking the tablet. Regular blood tests are recommended by your doctor while taking Digitran 0.25mg Tablet to monitor the amount of Digitran 0.25mg Tablet in the bloodstream as its toxicity can lead to several forms of heart rhythm disturbances, vomiting, nausea and visual disturbances. If you have beriberi disease caused by vitamin B1 deficiency, malabsorption syndrome (inability to absorb minerals from food) or any lung or kidney disease, please inform your doctor before taking Digitran 0.25mg Tablet so that the dose may be adjusted or an alternate medicine may be prescribed accordingly. Digitran 0.25mg Tablet has a very narrow therapeutic index. It means small differences in the dose of drugs in the body may lead to life-threatening conditions or serious side effects. This makes its use limited and requires close monitoring by doctors like regular electrocardiogram (ECG). So, try not to self-medicate and suggest Digitran 0.25mg Tablet to others.

Uses of Digitran 0.25mg Tablet

Treatment of Irregular heartbeats, Prevention of heart failure.

Directions for Use

Take Digitran 0.25mg Tablet with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Digitran 0.25mg Tablet is a cardiac glycoside that is used to treat heart failure and irregular heartbeats. Digitran 0.25mg Tablet increases the force with which the heart muscle contracts with each heartbeat and makes the heart efficient in pumping blood around the body. Thus, it slows down the rate at which the heart beats and makes the heart rate normal. Digitran 0.25mg Tablet improves heart failure symptoms such as exercise capacity and reduces the number of hospitalizations.

How Digitran 0.25mg Tablet Works

Digitran 0.25mg Tablet contains digoxin, i.e. cardiac glycosides that help to increase the output force of the heart and reduce the rate of heart contractions. Digitran 0.25mg Tablet works on the heart muscle directly and increases the force with which the heart muscle contracts with each heartbeat. Thereby, it makes the heart efficient in pumping blood around the body and slows down the rate at which the heart beats.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Digitran 0.25mg Tablet

  • Feeling confused
  • Dizziness
  • Nausea or vomiting
  • Loss of appetite
  • Diarrhoea
  • Changes in your vision (including blurred vision and not being able to look at bright light)

What if I have taken an overdose of Digitran 0.25mg Tablet

Do not take more than the prescribed dose of Digitran 0.25mg Tablet as it may cause overdose. The symptoms of overdose include loss of appetite, vomiting, nausea and feeling tired. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

If you are known to be allergic to Digitran 0.25mg Tablet or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking the tablet. Avoid intake of alcohol with Digitran 0.25mg Tablet as it may increase the risk of drowsiness. Digitran 0.25mg Tablet may cause vision problems in some people. Make sure you are not affected before driving. Regular blood tests are recommended by your doctor while taking Digitran 0.25mg Tablet to monitor the amount of digoxin in blood as digoxin toxicity can lead to several forms of heart rhythm disturbances, vomiting, nausea and visual disturbances. If you have beriberi disease caused by vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food), thyroid, or any lung or kidney disease, please inform your doctor before taking Digitran 0.25mg Tablet so that the dose may be adjusted or an alternate medicine may be prescribed accordingly. Digitran 0.25mg Tablet has a narrow therapeutic index which makes its use limited and requires close monitoring as small change in dose or blood concentration may lead to severe adverse effects, and overdose may lead to life-threatening reactions.

Drug-Drug Interactions

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DigoxinNadolol
Severe
DigoxinCeritinib
Severe

Drug-Drug Interactions

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DigoxinNadolol
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Co-administration of Digitran 0.25mg Tablet and Nadolol may slow down the heart rate and lead to increased side effects.

How to manage the interaction:
If you are supposed to take Digitran 0.25mg Tablet and Nadolol together, a doctor may adjust the dose to safely use both medications. However, if you experience decreased appetite, nausea, vomiting, confusion, diarrhea, seizures, visual changes, overtiredness, irregular heartbeats, and abnormally fast or slow heartbeats, contact a doctor. Do not discontinue the medication without consulting a doctor.
DigoxinCeritinib
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Co-administration of Digitran 0.25mg Tablet and Ceritinib may slow down the heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Digitran 0.25mg Tablet and ceritinib, it can be taken together if prescribed by a doctor. However, if you experience fainting, lightheadedness, sudden dizziness, or irregular heartbeat, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DigoxinAtazanavir
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Coadministration of Digitran 0.25mg Tablet and Atazanavir may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Digitran 0.25mg Tablet and Atazanavir, you can take these medicines together if prescribed by a doctor. However, if you develop fainting, lightheadedness, sudden dizziness, or irregular heartbeat, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DigoxinSaquinavir
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Co-administration of Digitran 0.25mg Tablet and Saquinavir may increase the risk of severe irregular heart rhythm.

How to manage the interaction:
If you are supposed to take Digitran 0.25mg Tablet and Saquinavir together, a doctor may adjust the dose or monitor more frequently to safely use both medications. However, if you develop lightheadedness, fainting, sudden dizziness, nausea, vomiting, loss of appetite, slow pulse, vision disturbances, or irregular heartbeat during treatment with these medications. Contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DigoxinAdenosine
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Co-administration of Adenosine with Digitran 0.25mg Tablet shows additive effects on the heart and may cause abnormal heart rhythms.

How to manage the interaction:
Taking Adenosine with Digitran 0.25mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as dizziness, difficulty in breathing, or chest pain. Do not discontinue any medications without consulting a doctor.
DigoxinAmiodarone
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Co-administration of Amiodarone with Digitran 0.25mg Tablet can increase Digitran 0.25mg Tablet levels which can lead to severe side effects.

How to manage the interaction:
Taking Amiodarone with Digitran 0.25mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, visual disturbances, slow pulse, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
DigoxinClarithromycin
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Co-administration of Clarithromycin with Digitran 0.25mg Tablet may increase the blood levels and effects of Digitran 0.25mg Tablet.

How to manage the interaction:
Although there is a possible interaction, Clarithromycin can be taken with Digitran 0.25mg Tablet if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of excessive Digitran 0.25mg Tablet levels such as diarrhea, nausea, loss of appetite, vomiting, visual disturbances, and an abnormally fast or slow or uneven heartbeat. Do not discontinue the medication without consulting a doctor.
DigoxinFamotidine
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Co-administration of Digitran 0.25mg Tablet and Famotidine may increase the level or effect of Digitran 0.25mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Digitran 0.25mg Tablet and Famotidine, you can take these medicines together if prescribed by a doctor. Do not discontinue the medication without consulting a doctor.
DigoxinSucralfate
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Co-administration of Sucralfate together with Digitran 0.25mg Tablet may decrease the effects of Digitran 0.25mg Tablet.

How to manage the interaction:
If you are supposed to take Digitran 0.25mg Tablet and Sucralfate together, your doctor may adjust the dose to safely use both medications. Do not discontinue the medication without consulting a doctor.
DigoxinTelaprevir
Severe
How does the drug interact with Digitran 0.25mg Tablet:
Co-administration of Digitran 0.25mg Tablet with Telaprevir may increase the blood levels and effects of Digitran 0.25mg Tablet.

How to manage the interaction:
Although taking Telaprevir and Digitran 0.25mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. Contact a doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive Digitran 0.25mg Tablet levels. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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DIGOXIN-0.25MGGrapefruit and Grapefruit Juice
Mild

Drug-Food Interactions

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DIGOXIN-0.25MGGrapefruit and Grapefruit Juice
Mild
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Digitran 0.25mg Tablet with Grapefruit and Grapefruit juice may increase the side effects of Digitran 0.25mg Tablet. Consuming Grapefruit and grapefruit juice should be avoided while taking Digitran 0.25mg Tablet.

Diet & Lifestyle Advise

  • Maintain a low salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.

  • Do the regular exercise as it helps to lower blood pressure and keeps blood vessels and heart in good condition.

  • Quit smoking as smoking increases blood pressure and heart rate.

  • Eat balanced and healthy diet which includes plenty of vegetables, fruits, low fat or fat free products.

Habit Forming

No

Therapeutic Class

ANTIARRHYTHMICS

Digitran 0.25mg Tablet Substitute

Substitutes safety advice
  • Lanoxin Tablet 10's

    1.31per tablet
  • Dixin 0.25 mg Tablet 10's

    1.28per tablet
  • Digoxin-0.25 Tablet 10's

    1.17per tablet
  • Digon 0.25 mg Tablet 10's

    1.26per tablet
  • DIXIN 0.25MG INJECTION 2ML

    3.75per tablet
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Digitran 0.25mg Tablet as it may increase drowsiness and reduce the amount of Digitran 0.25mg Tablet in blood leading to abnormal heart function.

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Pregnancy

Caution

Tablet: It is a Category C pregnancy drug and is to be given to pregnant women only if it is clearly needed and prescribed by a doctor.

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Breast Feeding

Safe if prescribed

Tablet: It is safe for breastfeeding mothers if prescribed by a doctor.

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Driving

Caution

Digitran 0.25mg Tablet may cause dizziness, yellow or blurred vision in some people. So, make sure you are not affected before driving or operating machinery.

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Liver

Safe if prescribed

If you have any concerns regarding the use of Digitran 0.25mg Tablet in patients with Liver problems, please consult a doctor.

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Kidney

Caution

Take Digitran 0.25mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Paediatric solution is to be used in children in doses as prescribed by a child specialist.

FAQs

Digitran 0.25mg Tablet is used to treat irregular heartbeats and manage the symptoms of heart failure. It works on the heart muscle directly and increases the force with which the heart muscle contracts with each heartbeat. Thereby, it makes the heart efficient in pumping blood around the body and slows down the rate at which the heart beats.
It may take several weeks for Digitran 0.25mg Tablet to show its effect. You are recommended to continue taking Digitran 0.25mg Tablet for as long as your doctor prescribes it and do not stop taking Digitran 0.25mg Tablet suddenly as it may worsen your heart problems. However, if you experience any difficulty while taking Digitran 0.25mg Tablet, please consult your doctor.
Yes, Digitran 0.25mg Tablet may cause diarrhoea as a side effect. However, it is not necessary for everyone taking Digitran 0.25mg Tablet to experience this side effect. You are recommended to drink plenty of fluids to avoid dehydration. Signs of dehydration include decreased urination or dark, strong-smelling urine. Also, do not take any other medicines to treat diarrhoea without consulting your doctor. If the condition persists or worsen, please consult your doctor.
Yes, Digitran 0.25mg Tablet may cause yellow or blurred vision in some people. Therefore, be cautious before driving or using machinery.
No, you can eat normally. However, a balanced and healthy diet are advised for effective results.
You are not recommended to take more than the prescribed dose of Digitran 0.25mg Tablet as it may cause Digitran 0.25mg Tablet toxicity resulting in symptoms such as vomiting, nausea, loss of appetite, tiredness, dizziness or visual disturbances (more than usual yellow-green). However, if you experience any of these symptoms while taking Digitran 0.25mg Tablet, please consult a doctor immediately.
No, you are not recommended to take amiodarone with Digitran 0.25mg Tablet as co-administration of these two medicines may increase the levels of Digitran 0.25mg Tablet in the blood resulting in Digitran 0.25mg Tablet toxicity. However, please consult a doctor before taking other medicines with Digitran 0.25mg Tablet so that the dose may be adjusted appropriately.
You are recommended to avoid taking Digitran 0.25mg Tablet if you have severe heart problems, have a history of Stokes-Adams attacks (abrupt, short-lived unconsciousness caused by a sudden change in a heartbeat), obstructive cardiomyopathy (enlargement of the heart muscle) and Wolff-Parkinson-White syndrome (extra electrical pathway causes fast heartbeat).
Digitran 0.25mg Tablet contains digoxin (a cardiac glycoside) that works directly on the heart muscle and increases the force with which the heart muscle contracts with each heartbeat. Thereby, it makes the heart efficient in pumping blood around the body and slows down the rate at which the heart beats.
The common side effects of Digitran 0.25mg Tablet include diarrhoea, nausea, vomiting, dizziness, abnormal heartbeat, and skin rash. If these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, India.
Other Info - DIGI278

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