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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Depakote 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. It helps block nerve transmission across the brain and provides a calming effect. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Prescription drug

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Composition :

DIVALPROEX-500MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

Depakote 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, Depakote 500 Tablet is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Depakote 500 Tablet contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Depakote 500 Tablet increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder. 

Take Depakote 500 Tablet with or without food. Depending on your medical condition, you are advised to take Depakote 500 Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Depakote 500 Tablet without consulting your doctor to avoid worsening seizures. Do not take Depakote 500 Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Depakote 500 Tablet . Consult your doctor before taking Depakote 500 Tablet if you are breastfeeding. Avoid driving or operating machinery as Depakote 500 Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Depakote 500 Tablet as it could lead to increased dizziness. Care should be taken while giving Depakote 500 Tablet to children below two years as there is a higher risk of liver intoxication during the first 6months of treatment. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Treatment of Epilepsy, bipolar disorder, migraine.
Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush it.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.Sprinkle capsule: Swallow it as a whole with water or sprinkle the capsule contents on food and consume.

Depakote 500 Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics. Depakote 500 Tablet is used to treat epilepsy/seizures/fits. Also, Depakote 500 Tablet is used to treat mood disorders and prevent migraine headaches. Depakote 500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures. Depakote 500 Tablet treats mood disorders by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Depakote 500 Tablet prevents migraine headaches by limiting the transmission of nerve pain. Depakote 500 Tablet is used alone or in combination to treat simple, complex partial, and complex absence seizures. Depakote 500 Tablet is used in combination to treat multiple seizures, such as absence seizures.

Depakote 500 Tablet contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Depakote 500 Tablet increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder.
Store in a cool and dry place away from sunlight
  • Abdominal pain

  • Back pain

  • Constipation

  • Diarrhoea

  • Dizziness

  • Nausea

  • Increased appetite

  • Vomiting

  • Vision problems

  • Weight changes

  • Problems with walking or coordination

Do not take more than the prescribed dose of Depakote 500 Tablet as it may cause overdose resulting in heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Do not take Depakote 500 Tablet if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking Depakote 500 Tablet if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendencies while taking Depakote 500 Tablet . Depakote 500 Tablet may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking Depakote 500 Tablet without consulting your doctor to avoid worsening of seizures. Do not take Depakote 500 Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Depakote 500 Tablet . Consult your doctor before taking Depakote 500 Tablet if you are breastfeeding. Avoid driving or operating machinery as Depakote 500 Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Depakote 500 Tablet as it could lead to increased dizziness. Care should be taken while giving Depakote 500 Tablet to children below 2 years as there is a higher risk of liver intoxication during the first six months of treatment.

verifiedApollotooltip
DivalproexGlycerol phenylbutyrate
Critical
DivalproexBexarotene
Severe

Drug-Drug Interactions

DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Depakote 500 Tablet 15's:
Coadministration of Glycerol phenylbutyrate and Depakote 500 Tablet 15's can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Depakote 500 Tablet 15's together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexBexarotene
Severe
How does the drug interact with Depakote 500 Tablet 15's:
Co-administration of Depakote 500 Tablet 15's and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Depakote 500 Tablet 15's and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexTeriflunomide
Severe
How does the drug interact with Depakote 500 Tablet 15's:
Co-administration of Depakote 500 Tablet 15's and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Depakote 500 Tablet 15's and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexEsketamine
Severe
How does the drug interact with Depakote 500 Tablet 15's:
Coadministration of Esketamine and Depakote 500 Tablet 15's can increase the side effects of esketamine.

How to manage the interaction:
Although taking Depakote 500 Tablet 15's and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexLeflunomide
Severe
How does the drug interact with Depakote 500 Tablet 15's:
Co-administration of Depakote 500 Tablet 15's and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Depakote 500 Tablet 15's and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DivalproexLamotrigine
Severe
How does the drug interact with Depakote 500 Tablet 15's:
Coadministration of Depakote 500 Tablet 15's and Lamotrigine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Depakote 500 Tablet 15's and Lamotrigine, you can take these medicines together if prescribed by your doctor. However, contact your doctor if you experience restlessness, rash, or muscle weakness. Do not stop using any medications without a doctor's advice.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Depakote 500 Tablet 15's:
Co-administration of Sodium phenylbutyrate and Depakote 500 Tablet 15's can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Depakote 500 Tablet 15's with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexLomitapide
Severe
How does the drug interact with Depakote 500 Tablet 15's:
Co-administration of Depakote 500 Tablet 15's and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Depakote 500 Tablet 15's and lomitapide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without the doctor's advice.
DivalproexSodium oxybate
Severe
How does the drug interact with Depakote 500 Tablet 15's:
Co-administration of Sodium oxybate and Depakote 500 Tablet 15's can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Depakote 500 Tablet 15's can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexMeropenem
Severe
How does the drug interact with Depakote 500 Tablet 15's:
Co-administration of Depakote 500 Tablet 15's and Meropenem can reduce the blood levels of Depakote 500 Tablet 15's sodium.

How to manage the interaction:
Co-administration of Depakote 500 Tablet 15's with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.

  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.

  • Exercising regularly helps in maintaining weight and improving overall health. 

  • Rest well, get plenty of sleep.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.

  • Have a seizure response plan, help those around you know what to do.

  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.

  • Understand what triggers seizures and try reducing or avoiding them.

  • Please pay attention to overall health as it can help in reducing seizure activity.

  • Install an alarm or emergency device to get assistance during a seizure attack.

No
ANTICONVULSANT

Depakote 500 Tablet Substitute

Substitutes safety advice
  • Desval ER 500 Tablet 10's

    17.42per tablet
  • Depakote XR 500 Tablet 15's

    23.52per tablet
  • Divalgress ER 500 Tablet 10's

    by AYUR

    13.68per tablet
  • Dipro 500mg Tablet 10's

    11.43per tablet
  • Divalprid-OD 500 Tablet 10's

    21.15per tablet
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FAQs

Depakote 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.
Depakote 500 Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.
Depakote 500 Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.
Depakote 500 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.
Depakote 500 Tablet may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Depakote 500 Tablet only after consulting a doctor.
Depakote 500 Tablet may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.
Do not discontinue Depakote 500 Tablet without consulting your doctor. To treat your condition effectually, continue taking Depakote 500 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Depakote 500 Tablet ; your doctor will gradually reduce the dose to avoid worsening seizures.
Before taking Depakote 500 Tablet , certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.
Depakote 500 Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Depakote 500 Tablet .
Topiramate (anticonvulsant) should not be taken along with Depakote 500 Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.
It's crucial to consult with your doctor before discontinuing Depakote 500 Tablet . Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.
Depakote 500 Tablet is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.
Depakote 500 Tablet can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.
Yes, Depakote 500 Tablet can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Depakote 500 Tablet , it's essential to consult with your doctor.
Yes, Depakote 500 Tablet can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Depakote 500 Tablet , seeking medical attention is crucial.
Avoid consumption of alcohol while taking Depakote 500 Tablet as it may cause increased dizziness.
If you experience abdominal pain, nausea, and anorexia while taking Depakote 500 Tablet , it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.
Overdose of Depakote 500 Tablet can be a severe medical emergency. If you or someone you know has taken an overdose of Depakote 500 Tablet , it's crucial to seek immediate medical attention.
Depakote 500 Tablet can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
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