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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
ADIVAL ER 500MG TABLET is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. It helps block nerve transmission across the brain and provides a calming effect. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

DIVALPROEX-500MG

Manufacturer/Marketer :

Lotus Life Sciences

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About ADIVAL ER 500MG TABLET

ADIVAL ER 500MG TABLET is used to treat epilepsy/seizures/fits. Additionally, ADIVAL ER 500MG TABLET is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

ADIVAL ER 500MG TABLET contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. ADIVAL ER 500MG TABLET increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder. 

Take ADIVAL ER 500MG TABLET with or without food. Depending on your medical condition, you are advised to take ADIVAL ER 500MG TABLET for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking ADIVAL ER 500MG TABLET without consulting your doctor to avoid worsening seizures. Do not take ADIVAL ER 500MG TABLET if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking ADIVAL ER 500MG TABLET. Consult your doctor before taking ADIVAL ER 500MG TABLET if you are breastfeeding. Avoid driving or operating machinery as ADIVAL ER 500MG TABLET causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with ADIVAL ER 500MG TABLET as it could lead to increased dizziness. Care should be taken while giving ADIVAL ER 500MG TABLET to children below two years as there is a higher risk of liver intoxication during the first 6months of treatment. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of ADIVAL ER 500MG TABLET

Treatment of Epilepsy, bipolar disorder, migraine.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush it.Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack; shake the pack well before each use.Sprinkle capsule: Swallow it as a whole with water or sprinkle the capsule contents on food and consume.

Medicinal Benefits

ADIVAL ER 500MG TABLET belongs to a group of medicines called anticonvulsants or anti-epileptics. ADIVAL ER 500MG TABLET is used to treat epilepsy/seizures/fits. Also, ADIVAL ER 500MG TABLET is used to treat mood disorders and prevent migraine headaches. ADIVAL ER 500MG TABLET decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures. ADIVAL ER 500MG TABLET treats mood disorders by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. ADIVAL ER 500MG TABLET prevents migraine headaches by limiting the transmission of nerve pain. ADIVAL ER 500MG TABLET is used alone or in combination to treat simple, complex partial, and complex absence seizures. ADIVAL ER 500MG TABLET is used in combination to treat multiple seizures, such as absence seizures.

How ADIVAL ER 500MG TABLET Works

ADIVAL ER 500MG TABLET contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. ADIVAL ER 500MG TABLET increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder.

Storage

Store in a cool and dry place away from sunlight

Side Effects of ADIVAL ER 500MG TABLET

  • Abdominal pain

  • Back pain

  • Constipation

  • Diarrhoea

  • Dizziness

  • Nausea

  • Increased appetite

  • Vomiting

  • Vision problems

  • Weight changes

  • Problems with walking or coordination

What if I have taken an overdose of ADIVAL ER 500MG TABLET

Do not take more than the prescribed dose of ADIVAL ER 500MG TABLET as it may cause overdose resulting in heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take ADIVAL ER 500MG TABLET if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking ADIVAL ER 500MG TABLET if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendencies while taking ADIVAL ER 500MG TABLET. ADIVAL ER 500MG TABLET may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking ADIVAL ER 500MG TABLET without consulting your doctor to avoid worsening of seizures. Do not take ADIVAL ER 500MG TABLET if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking ADIVAL ER 500MG TABLET. Consult your doctor before taking ADIVAL ER 500MG TABLET if you are breastfeeding. Avoid driving or operating machinery as ADIVAL ER 500MG TABLET causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with ADIVAL ER 500MG TABLET as it could lead to increased dizziness. Care should be taken while giving ADIVAL ER 500MG TABLET to children below 2 years as there is a higher risk of liver intoxication during the first six months of treatment.

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateTeriflunomide
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with ADIVAL ER 500MG TABLET:
Combining Sodium phenylbutyrate and ADIVAL ER 500MG TABLET can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with ADIVAL ER 500MG TABLET is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with ADIVAL ER 500MG TABLET:
Co-administration of Teriflunomide and ADIVAL ER 500MG TABLET can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and ADIVAL ER 500MG TABLET can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with ADIVAL ER 500MG TABLET:
Co-administration of Leflunomide and ADIVAL ER 500MG TABLET can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and ADIVAL ER 500MG TABLET can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with ADIVAL ER 500MG TABLET:
Co-administration of Meropenam and ADIVAL ER 500MG TABLET together can reduce the effect of ADIVAL ER 500MG TABLET.

How to manage the interaction:
Co-administration of Meropenam and ADIVAL ER 500MG TABLET can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with ADIVAL ER 500MG TABLET:
Co-administration of Ketamine and ADIVAL ER 500MG TABLET can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and ADIVAL ER 500MG TABLET can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with ADIVAL ER 500MG TABLET:
The combined use of Ertapenem and ADIVAL ER 500MG TABLET can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and ADIVAL ER 500MG TABLET can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with ADIVAL ER 500MG TABLET:
Co-administration of ADIVAL ER 500MG TABLET with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and ADIVAL ER 500MG TABLET can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with ADIVAL ER 500MG TABLET:
Using buprenorphine together with ADIVAL ER 500MG TABLET may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside ADIVAL ER 500MG TABLET can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with ADIVAL ER 500MG TABLET:
Co-administration of Lithium with ADIVAL ER 500MG TABLET can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and ADIVAL ER 500MG TABLET can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with ADIVAL ER 500MG TABLET:
Co-administration of Vorinostat with ADIVAL ER 500MG TABLET can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and ADIVAL ER 500MG TABLET can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.

  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.

  • Exercising regularly helps in maintaining weight and improving overall health. 

  • Rest well, get plenty of sleep.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.

  • Have a seizure response plan, help those around you know what to do.

  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.

  • Understand what triggers seizures and try reducing or avoiding them.

  • Please pay attention to overall health as it can help in reducing seizure activity.

  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

ADIVAL ER 500MG TABLET Substitute

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Alcohol

Unsafe

Avoid consumption of alcohol while taking ADIVAL ER 500MG TABLET as it may cause increased dizziness.

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Pregnancy

Unsafe

ADIVAL ER 500MG TABLET belongs to pregnancy category D. Avoid taking ADIVAL ER 500MG TABLET if you are pregnant as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Caution

ADIVAL ER 500MG TABLET may pass into breastmilk. Consult your doctor before taking ADIVAL ER 500MG TABLET if you are breastfeeding.

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Driving

Unsafe

ADIVAL ER 500MG TABLET causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

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Liver

Caution

ADIVAL ER 500MG TABLET should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

ADIVAL ER 500MG TABLET can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years as they are at a higher risk of liver toxicity.

FAQs

ADIVAL ER 500MG TABLET is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.
ADIVAL ER 500MG TABLET decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.
ADIVAL ER 500MG TABLET helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.
ADIVAL ER 500MG TABLET limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.
ADIVAL ER 500MG TABLET may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with ADIVAL ER 500MG TABLET only after consulting a doctor.
ADIVAL ER 500MG TABLET may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.
Do not discontinue ADIVAL ER 500MG TABLET without consulting your doctor. To treat your condition effectually, continue taking ADIVAL ER 500MG TABLET for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking ADIVAL ER 500MG TABLET; your doctor will gradually reduce the dose to avoid worsening seizures.
Before taking ADIVAL ER 500MG TABLET, certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.
ADIVAL ER 500MG TABLET may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking ADIVAL ER 500MG TABLET.
Topiramate (anticonvulsant) should not be taken along with ADIVAL ER 500MG TABLET as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.
It's crucial to consult with your doctor before discontinuing ADIVAL ER 500MG TABLET. Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.
ADIVAL ER 500MG TABLET is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.
ADIVAL ER 500MG TABLET can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.
Yes, ADIVAL ER 500MG TABLET can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking ADIVAL ER 500MG TABLET, it's essential to consult with your doctor.
Yes, ADIVAL ER 500MG TABLET can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking ADIVAL ER 500MG TABLET, seeking medical attention is crucial.
Avoid consumption of alcohol while taking ADIVAL ER 500MG TABLET as it may cause increased dizziness.
If you experience abdominal pain, nausea, and anorexia while taking ADIVAL ER 500MG TABLET, it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.
Overdose of ADIVAL ER 500MG TABLET can be a severe medical emergency. If you or someone you know has taken an overdose of ADIVAL ER 500MG TABLET, it's crucial to seek immediate medical attention.
ADIVAL ER 500MG TABLET can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Country of origin

INDIA

Manufacturer/Marketer address

lls, lakshmi nilayam, ravindranagar, nacharam, hyderabad - 500076.
Other Info - ADI0089

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