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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Darzalex Injection is used to treat a type of blood cancer called multiple myeloma in adults 18 years or older. It contains Daratumumab, a monoclonal antibody. Monoclonal antibodies are proteins that recognize and bind to specific targets within the body. Daratumumab is a targeted monoclonal antibody meant to bind to specific cancer cells in your body that help slow or stop the progression of multiple myeloma; it directly kills multiple myeloma cells and/or allows your immune system to identify and destroy them.

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Whats That

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Composition :

DARATUMUMAB-100MG

Manufacturer/Marketer :

Janssen Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Darzalex Injection

Darzalex Injection belongs to the group of monoclonal antibodies (anti-cancer medicines) used to treat a type of blood cancer called multiple myeloma in adults 18 years or older. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Daratumumab, a monoclonal antibody, is present in Darzalex Injection. Daratumumab is meant to bind to certain cancer cells in your body, either directly killing multiple myeloma cells and/or allowing your immune system to identify and destroy them.

Darzalex Injection should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as Chills, sore throat, cough, feeling sick (nausea), vomiting, itchy, runny or blocked nose, feeling short of breath or other breathing problems, chest discomfort, dizziness or light-headedness (hypotension), itching and wheezing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Before taking the Darzalex Injection, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Darzalex Injection can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months afterwards. Before beginning treatment, discuss effective contraception with your healthcare professional. Inform them immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Alcohol should be avoided during treatment with this medicine. Drive only if alert, as the Darzalex Injection may cause drowsiness or dizziness.

Uses of Darzalex Injection

Treatment of Multiple myeloma

Directions for Use

Darzalex Injection should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.

Medicinal Benefits

Daratumumab, a monoclonal antibody, is present in Darzalex Injection. Monoclonal antibodies are proteins that recognize and bind to specific targets within the body. Daratumumab is a targeted monoclonal antibody meant to bind to certain cancer cells in your body that helps slow or stop the progression of multiple myeloma; it directly kills multiple myeloma cells and/or allows your immune system to identify and destroy them.

How Darzalex Injection Works

Daratumumab, a monoclonal antibody, is present in Darzalex Injection. Daratumumab is meant to bind to certain cancer cells in your body, either directly killing multiple myeloma cells and/or allowing your immune system to identify and destroy them.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Darzalex Injection

  • Chills
  • Sore throat, cough
  • Feeling sick (nausea)
  • Vomiting
  • Itchy, runny, or blocked nose
  • Feeling short of breath or other breathing problems
  • Chest discomfort
  • Dizziness or light-headedness (hypotension)
  • Itching
  • Wheezing

What if I have taken an overdose of Darzalex Injection

As Darzalex Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Before taking Darzalex Injection, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Avoid taking Darzalex Injection if you are pregnant or breastfeeding or allergic to any component present in Darzalex Injection. Both women and men using this Darzalex Injection should use birth control to avoid pregnancy. Inform your doctor if you have a history of low blood pressure; your doctor will closely monitor and manage it. If you are taking medication to help lower your blood pressure, you may need to reduce or discontinue it while taking Daratumumab.

Drug-Drug Interactions

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DaratumumabCladribine
Severe
DaratumumabClozapine
Severe

Drug-Drug Interactions

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DaratumumabCladribine
Severe
How does the drug interact with Darzalex Injection 15 ml:
The combined use of cladribine with Darzalex Injection 15 ml can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Darzalex Injection 15 ml and Cladribine, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without first talking to your doctor.
DaratumumabClozapine
Severe
How does the drug interact with Darzalex Injection 15 ml:
Taking Darzalex Injection 15 ml and clozapine may increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Darzalex Injection 15 ml and Clozapine, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems with your current medication. Don't worry, there are solutions available to help you feel better. Do not discontinue any medications without first consulting your doctor.
DaratumumabEtanercept
Severe
How does the drug interact with Darzalex Injection 15 ml:
When Etanercept is used with Darzalex Injection 15 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Darzalex Injection 15 ml with Etanercept together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
DaratumumabBaricitinib
Severe
How does the drug interact with Darzalex Injection 15 ml:
Coadministration of baricitinib and Darzalex Injection 15 ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Darzalex Injection 15 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
DaratumumabTofacitinib
Severe
How does the drug interact with Darzalex Injection 15 ml:
Using tofacitinib together with Darzalex Injection 15 ml may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Darzalex Injection 15 ml, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
DaratumumabInfliximab
Severe
How does the drug interact with Darzalex Injection 15 ml:
Combining Infliximab with Darzalex Injection 15 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Darzalex Injection 15 ml with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

MONOCLONAL ANTIBODIES

Darzalex Injection Substitute

Substitutes safety advice
  • Darzalex Injection

    by Others

    3099.60per tablet
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Darzalex Injection.

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Pregnancy

Unsafe

Darzalex Injection should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy.

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Breast Feeding

Unsafe

You should not breastfeed when taking Darzalex Injection as it is unknown if the Daratumumab can pass to your baby in the milk.

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Driving

Caution

Darzalex Injection can cause a drop in blood pressure, which can make you feel dizzy, lightheaded or like you are about to faint. If you feel dizzy or lightheaded when taking Darzalex Injection, you should not operate machinery or drive a car.

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Liver

Caution

Limited information is available. Please inform your doctor before prescribing Darzalex Injection if you have liver impairment. Your doctor will weigh the benefits and potential risks before prescribing Darzalex Injection.

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Kidney

Caution

Limited information is available. Please inform your doctor before prescribing Darzalex Injection if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Darzalex Injection.

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Children

Caution

Do not use this medicine for children between 0 to 18 years old.

FAQs

Darzalex Injection is used to treat Multiple myeloma.

Daratumumab, a monoclonal antibody, is present in Darzalex Injection. Monoclonal antibodies are proteins that recognize and bind to specific targets within the body. Daratumumab directly kills multiple myeloma cells and/or allows your immune system to identify and destroy them.

No, it is unsafe to father a child while taking Darzalex Injection. It is recommended for sexually active men to use condoms while on treatment and for at least six months after their last dose of Darzalex Injection.

Darzalex Injection can affect the results of this blood test. Tell the person doing the test that you are using Darzalex Injection.

Based on the medical condition, Darzalex Injection may be given alone or together with other medicines used to treat multiple myeloma.

Tell your healthcare professional immediately if you get any signs of an infusion-related reaction during or three days after the infusion. Your doctor may give other medicines, or the infusion may need to be slowed down or stopped.

Darzalex Injection can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment. Tell your healthcare provider if you develop a fever or have signs of bruising or bleeding.

Country of origin

India

Manufacturer/Marketer address

Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Other Info - DAR0079

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Keep Refrigerated. Do not freeze.Prepaid payment required.

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