Darzalex Injection belongs to the group of monoclonal antibodies (anti-cancer medicines) used to treat a type of blood cancer called multiple myeloma in adults 18 years or older. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Daratumumab, a monoclonal antibody, is present in Darzalex Injection. Daratumumab is meant to bind to certain cancer cells in your body, either directly killing multiple myeloma cells and/or allowing your immune system to identify and destroy them.

Darzalex Injection should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as Chills, sore throat, cough, feeling sick (nausea), vomiting, itchy, runny or blocked nose, feeling short of breath or other breathing problems, chest discomfort, dizziness or light-headedness (hypotension), itching and wheezing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Before taking the Darzalex Injection, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Darzalex Injection can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months afterwards. Before beginning treatment, discuss effective contraception with your healthcare professional. Inform them immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Alcohol should be avoided during treatment with this medicine. Drive only if alert, as the Darzalex Injection may cause drowsiness or dizziness.

Daratumumab, a monoclonal antibody, is present in Darzalex Injection. Monoclonal antibodies are proteins that recognize and bind to specific targets within the body. Daratumumab is a targeted monoclonal antibody meant to bind to certain cancer cells in your body that helps slow or stop the progression of multiple myeloma; it directly kills multiple myeloma cells and/or allows your immune system to identify and destroy them.

• Chills
• Sore throat, cough
• Feeling sick (nausea)
• Vomiting
• Itchy, runny, or blocked nose
• Feeling short of breath or other breathing problems
• Chest discomfort
• Dizziness or light-headedness (hypotension)
• Itching
• Wheezing

Before taking Darzalex Injection, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Avoid taking Darzalex Injection if you are pregnant or breastfeeding or allergic to any component present in Darzalex Injection. Both women and men using this Darzalex Injection should use birth control to avoid pregnancy. Inform your doctor if you have a history of low blood pressure; your doctor will closely monitor and manage it. If you are taking medication to help lower your blood pressure, you may need to reduce or discontinue it while taking Daratumumab.

Drug-Drug Interactions: Darzalex Injection may interact with monoclonal antibodies (e.g. adalimumab), immunomodulatory medication (e.g. baricitinib, fingolimod), vaccines (e.g. BCG Vaccine, Denue vaccine), and antipsychotic medication (e.g. clozapine).

Drug-Food Interactions: Avoid the consumption of alcoholic beverages.

Drug-Disease Interactions: Inform your doctor if you have Low blood pressure, hereditary fructose intolerance (HFI), breathing problems, shingles (herpes zoster) and renal or hepatic impairment and infections (Bacterial/Fungal/Protozoal/Viral).

• ADALIMUMAB
• BARICITINIB
• FINGOLIMOD
• BCG VACCINE
• DENGUE VACCINE
• CLONAZEPAM

• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
• Performing yoga may also help in improving both physical and mental health.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Eat a healthy diet and exercise regularly to maintain proper weight.
• Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
• Get optimal sleep; rest well.
• Avoid smoking and alcohol consumption.
• Avoid fast food, fried food, processed meats, refined carbs and added sugars.

• Monitoring of complete blood count while taking Darzalex Injection is advised.
• Drink plenty of fluids to prevent urinary problems.
• If you are due to have any surgery, inform the doctor that you are taking Darzalex Injection.
• Insomnia or difficulty sleeping at night is a common side effect of Daratumumab. This may be minimised by taking Daratumumab in the morning.
• Women who are being given Darzalex Injection should use effective contraception during treatment and for three months after treatment.

Myeloma, also called multiple myeloma, is a cancer of the plasma cells. Plasma cells are white blood cells that make antibodies that protect us from infection. In myeloma, the cells grow too much, crowding out normal cells in the bone marrow that make red blood cells, platelets, and other white blood cells. Multiple myeloma, the most common type of plasma cell tumour, develops in the bone marrow and can spread throughout the body.