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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Dandrotin 200mg Tablet is an antifungal medicine used in the treatment of fungal infections such as blastomycosis, coccidioidomycosis, paracoccidioidomycosis, and histoplasmosis (lung infection caused by Histoplasma fungus). This medicine works by inhibiting the growth and multiplication of fungal cells that are responsible for the growth of infection-causing fungi.
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Whats That

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Composition :

KETOCONAZOLE-200MG

Manufacturer/Marketer :

Carlton Dermatology

Consume Type :

ORAL

Return Policy :

Not Returnable

About Dandrotin 200mg Tablet

Dandrotin 200mg Tablet belongs to a class of drugs called antifungals indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus). It is used only when other effective antifungal therapies are not available or tolerated and if potential benefits outweigh potential risks.

Dandrotin 200mg Tablet contains Ketoconazole which works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

Take Dandrotin 200mg Tablet as prescribed. Your doctor will advise you on how often you need to take Dandrotin 200mg Tablet based on your medical condition. Some people may experience headache, nausea, stomach pain, and diarrhoea. Most of these side effects of Dandrotin 200mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

If you are allergic to Ketoconazole or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, inform your doctor before taking Dandrotin 200mg Tablet. Avoid breastfeeding while taking Dandrotin 200mg Tablet as it may be excreted in breast milk. You are recommended to avoid alcohol consumption whilst on treatment with Dandrotin 200mg Tablet. Dandrotin 200mg Tablet is not recommended for children below 2 years of age. For children above 2 years, it is recommended to use only if the doctor has determined that the benefits outweigh the risks.

Uses of Dandrotin 200mg Tablet

Treatment of Systemic fungal infections

Directions for Use

Take Dandrotin 200mg Tablet with food to avoid stomach upset or take it as advised by the doctor. Swallow the whole tablet/capsule with a glass of water. Do not break, crush or chew it.

Medicinal Benefits

Dandrotin 200mg Tablet is an antifungal used to treat severe fungal infections. It is used only when other effective antifungal therapies are not available or tolerated and if potential benefits outweigh potential risks. It destroys fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

How Dandrotin 200mg Tablet Works

Dandrotin 200mg Tablet contains Ketoconazole which works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Dandrotin 200mg Tablet

  • Headache
  • Nausea
  • Stomach pain
  • Diarrhoea 

What if I have taken an overdose of Dandrotin 200mg Tablet

Never take more than the prescribed dose. When Dandrotin 200mg Tablet is used at high doses, it may, though unlikely, result in decreased testosterone levels, sperm production, and an issue with the adrenal glands (adrenal insufficiency). Seek emergency medical help if an overdose is suspected.

Drug Warnings

If you are allergic to Ketoconazole or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, inform your doctor before taking Dandrotin 200mg Tablet. Avoid breastfeeding while taking Dandrotin 200mg Tablet as it may be excreted in breast milk. You are recommended to avoid alcohol consumption with Dandrotin 200mg Tablet. If you have a loss of appetite, tiredness, stomach pain, vomiting, yellowing of skin or eyes, dark urine, or light-coloured stools, inform your doctor immediately as they might be symptoms of hepatotoxicity (liver damage). 

Drug-Drug Interactions

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KetoconazoleNaloxegol
Critical
KetoconazoleLurasidone
Critical

Drug-Drug Interactions

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KetoconazoleNaloxegol
Critical
How does the drug interact with Dandrotin 200mg Tablet:
When Naloxegol is taken with Dandrotin 200mg Tablet, it can increase the blood levels of naloxegol which may cause the side effects.

How to manage the interaction:
Taking Dandrotin 200mg Tablet with Naloxegol is not recommended as it can cause an interaction, but it can be taken if prescribe by the doctor. However, if you experience symptoms such as sweating, tearing, runny nose, chills, diarrhea, stomach pain, anxiety, difficulty sleeping, irritability, restlessness, and yawning, consult the doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleLurasidone
Critical
How does the drug interact with Dandrotin 200mg Tablet:
Using Lurasidone together with Dandrotin 200mg Tablet may increase the risk of side effects like Parkinson's disease(It is a brain disorder that produces uncontrollable movements).

How to manage the interaction:
While lurasidone and Dandrotin 200mg Tablet is not recommended as it may lead to an interaction, they can be used if prescribed by a doctor. However, consult a doctor if you have any abnormal muscle activity, fits, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
KetoconazoleIsavuconazole
Critical
How does the drug interact with Dandrotin 200mg Tablet:
Co-administration of Dandrotin 200mg Tablet and Isavuconazole can significantly increase the blood levels of Isavuconazole, which may increase the risk of side effects.

How to manage the interaction:
Taking Isavuconazole with Dandrotin 200mg Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, stomach pain, headache while on therapy with these drugs, consult the doctor. Do not discontinue any medication without consulting a doctor.
KetoconazoleColchicine
Critical
How does the drug interact with Dandrotin 200mg Tablet:
Using colchicine together with Dandrotin 200mg Tablet may increase the blood levels of colchicine, increasing the risk of serious side effects.

How to manage the interaction:
Although taking Dandrotin 200mg Tablet with Colchicine is not recommended as it can cause an interaction, they can be taken if prescribed by a doctor. However, contact a doctor if you experience abdominal pain, nausea, vomiting, diarrhea, fever, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet. Do not stop using any medications without consulting a doctor
KetoconazoleVenetoclax
Critical
How does the drug interact with Dandrotin 200mg Tablet:
When Venetoclax is taken with Dandrotin 200mg Tablet, it can increase the risk of side effects.

How to manage the interaction:
Taking Dandrotin 200mg Tablet with Venetoclax is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. if you experience nausea, vomiting, diarrhea, fatigue, bleeding problems, and infections, consult a doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleEplerenone
Critical
How does the drug interact with Dandrotin 200mg Tablet:
Coadministration of Dandrotin 200mg Tablet with Eplerenone can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Dandrotin 200mg Tablet with Eplerenone is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
KetoconazoleMethylergometrine
Critical
How does the drug interact with Dandrotin 200mg Tablet:
Using Dandrotin 200mg Tablet with Methylergometrine can increase the concentration of Methylergometrine, which may lead to side effects.

How to manage the interaction:
Taking Dandrotin 200mg Tablet with Methylergometrine is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
KetoconazoleCisapride
Critical
How does the drug interact with Dandrotin 200mg Tablet:
When Cisapride is taken with Dandrotin 200mg Tablet, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Cisapride with Dandrotin 200mg Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleSilodosin
Critical
How does the drug interact with Dandrotin 200mg Tablet:
Coadministration of Silodosin with Dandrotin 200mg Tablet may lead to side effects including extremely low blood pressure, and increased heart rate.

How to manage the interaction:
Taking Dandrotin 200mg Tablet with Silodosin together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, heart palpitation. Do not discontinue any medications without consulting a doctor.
KetoconazoleTriazolam
Critical
How does the drug interact with Dandrotin 200mg Tablet:
When Triazolam is taken with Dandrotin 200mg Tablet, it can increase the risk of drowsiness and slowed breathing.

How to manage the interaction:
Taking Triazolam with Dandrotin 200mg Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or its juice with Dandrotin 200mg Tablet may result in side effects such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, dark urine, light colored stools, and yellowing of the skin or eyes. Avoid consuming grapefruit, grapefruit juice, or any supplements that include grapefruit extract while taking Dandrotin 200mg Tablet.

Diet & Lifestyle Advise

  • Avoid high-risk areas such as renovated buildings, construction sites, pigeon or chick coops, and caves.
  • Wear a respiratory mask when there is a risk of exposure to spores.
  • People with a weak immune system are advised to avoid activities that involve close contact with dust or dirt including digging, yard work, and gardening.
  • Close windows and stay inside during dust storms.
  • Clean skin injuries well with soap and water to reduce the risk of developing a skin infection.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS - ORAL

Dandrotin 200mg Tablet Substitute

Substitutes safety advice
  • Fungicide Tablet 10's

    47.52per tablet
  • Phytoral Tablet 10's

    46.08per tablet
  • Kenz Tablet 10's

    by AYUR

    21.60per tablet
  • Hyphoral Tablet 10's

    38.03per tablet
  • Ketocip 200 mg Tablet 10's

    21.78per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Dandrotin 200mg Tablet as it may increase the risk of liver damage and cause adverse effects.

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Pregnancy

Caution

Dandrotin 200mg Tablet is a Category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Unsafe

Dandrotin 200mg Tablet may be excreted in breast milk. Therefore, it is recommended to avoid breastfeeding while taking Dandrotin 200mg Tablet.

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Driving

Caution

Dandrotin 200mg Tablet may cause dizziness or drowsiness. Therefore, drive only if you alert after taking Dandrotin 200mg Tablet.

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Liver

Unsafe

Dandrotin 200mg Tablet is contraindicated in patients with chronic or acute liver disease. Therefore, inform your doctor if you have any Liver diseases/conditions.

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Kidney

Caution

If you have any concerns regarding the use of Dandrotin 200mg Tablet in patients with kiver diseases/conditions, consult a doctor.

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Children

Caution

Dandrotin 200mg Tablet is not recommended for children below 2 years of age. For children above 2 years, it is recommended to use only if the doctor has determined that benefits outweigh risks.

FAQs

Dandrotin 200mg Tablet belongs to a class of drugs called antifungals indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus).
Dandrotin 200mg Tablet works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.
Dandrotin 200mg Tablet is not recommended to treat fungal meningitis (fungal infection spreads to the brain and spinal cord) as it poorly penetrates into the cerebrospinal fluid. Therefore, inform your doctor if you have fungal meningitis so that appropriate medication may be prescribed.
You are recommended to avoid foods containing chocolate and caffeine such as cocoa beans, tea, coffee, cola and energy drinks while taking Dandrotin 200mg Tablet as it may increase the adverse effects of caffeine such as drowsiness, nervousness or nausea.
You are not recommended to take Dandrotin 200mg Tablet with simvastatin (lipid-lowering drug) as co-administration of these medicines may cause muscle problems. Therefore, please consult a doctor before taking Dandrotin 200mg Tablet with other medicines.
No, you are not recommended to stop taking Dandrotin 200mg Tablet without consulting your doctor as it may cause recurring infection. Therefore, take Dandrotin 200mg Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Dandrotin 200mg Tablet, please consult your doctor.

Country of origin

India
Other Info - DA88966

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