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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:48 PM IST
Crimat 25 mg Injection is used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care. It contains Atracurium, which stops sending pain signal to the brain, relieves muscle stiffness or muscle spasm. It is also used during general anaesthesia to ease tracheal intubation (a tube into the windpipe) and controlled ventilation.
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Prescription drug

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Composition :

ATRACURIUM-25MG

Manufacturer/Marketer :

Miracle Formulations India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Crimat 25 mg Injection

Crimat 25 mg Injection belongs to the group of medicines called skeletal muscle relaxants used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms.

Crimat 25 mg Injection contains ‘Atracurium’ that works by blocking the action of acetylcholine on skeletal muscles. Thus, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery. Crimat 25 mg Injection is used during surgery.  It is also used during general anaesthesia to ease tracheal intubation (a tube into the windpipe) and controlled ventilation.

Crimat 25 mg Injection is given by the healthcare professional during surgery.  In some cases, you may experience tachycardia (rapid heartbeat), temporary hypotension (low blood pressure), wheezing, bronchospasm (asthma-like symptoms), skin flushing, and urticaria (nettle rash). Most of these side effects of Crimat 25 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before receiving Crimat 25 mg Injection inform your doctor if you have had myasthenia gravis or Eaton-Lambert syndrome,  severe electrolyte disorder, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns and lack of adequate circulatory filling (hypovolaemia), pregnant or breastfeeding mother. Your doctor will prescribe Crimat 25 mg Injection only if the benefits outweigh the risks. Crimat 25 mg Injection is not recommended in neonates (children under the age of one month). Crimat 25 mg Injection is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer or the fridge.

Uses of Crimat 25 mg Injection

Treatment of Muscle contraction during surgery.

Directions for Use

A healthcare professional will administer Crimat 25 mg Injection under carefully controlled conditions. Do not self-administer Crimat 25 mg Injection .

Medicinal Benefits

Crimat 25 mg Injection belongs to the group of medicines called muscle relaxants used to reduce and relieve muscle contraction (excessive tension in the muscles) during surgery, other procedures, and in intensive care. It is also used to calm muscles while on a breathing machine, during general anaesthesia to ease tracheal intubation (a tube into the windpipe), and controlled ventilation. It works by blocking the action of acetylcholine on skeletal muscles. Also, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery. An experienced doctor must give Crimat 25 mg Injection under carefully controlled conditions. It is used during procedures that require that the patient is fully anaesthetized (unconscious) or heavily sedated.

How Crimat 25 mg Injection Works

Crimat 25 mg Injection contains ‘Atracurium’ that works by blocking the action of acetylcholine on skeletal muscles. Thus, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Crimat 25 mg Injection

  • Tachycardia (rapid heartbeat)
  • Temporary hypotension (low blood pressure)
  • Wheezing
  • Bronchospasm (asthma-like symptoms)
  • Skin flushing
  • Urticaria (nettle rash)

What if I have taken an overdose of Crimat 25 mg Injection

The overdose of Crimat 25 mg Injection is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Crimat 25 mg Injection , please inform your doctor immediately.

Drug Warnings

Before you receive Crimat 25 mg Injection , tell your doctor if you have a disease that affects the muscles and nervous control (neuromuscular disease such as myasthenia gravis or Eaton-Lambert syndrome (muscle disorder)), a severe electrolyte disorder, cancer spread widely from a primary source (carcinomatosis), a sensitivity to histamine, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns, lack of adequate circulatory filling (hypovolaemia). Crimat 25 mg Injection should not be given to pregnant women unless prescribed. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Crimat 25 mg Injection . Mothers should stop breastfeeding for 24 hours after receiving Crimat 25 mg Injection . Crimat 25 mg Injection is not recommended in neonates (children under the age of one month) as safety and effectiveness in pediatric patients below the age of 1 month have not been established. Crimat 25 mg Injection some formulations containing benzyl alcohol. In neonates, benzyl alcohol has been associated with an increased incidence of neurological and other complications, sometimes fatal.

Drug-Drug Interactions

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AtracuriumStreptomycin
Severe
AtracuriumPolymyxin b
Severe

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • Avoid freezing and hot temperatures.

  • Avoid wearing tight-fitting clothes. Instead, wear loose garments.

  • Rest well, and get plenty of sleep.

  • To avoid developing pressure sores, change your position every two hours.

  • Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot pack on the muscle for 15-20minutes.

  • Stay hydrated, and drink plenty of water.

Habit Forming

No

Therapeutic Class

MUSCLE RELAXANTS/SKELETAL MUSCLE RELAXANTS

Crimat 25 mg Injection Substitute

Substitutes safety advice
  • TRACRIUM 25MG INJECTION 2.5ML

    2.38per tablet
  • Atacurium 25 mg Injection 2.5 ml

    21.40per tablet
  • Arium 25 mg Injection 2.5 ml

    66.22per tablet
  • Atraplen 25 mg Injection 1's

    131.71per tablet
  • Skelatra 25mg Injection

    42.30per tablet
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Alcohol

Caution

Avoid consumption of alcohol after taking Crimat 25 mg Injection as it may increase the risk of side effects.

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Pregnancy

Caution

If you are pregnant, inform your doctor before receiving Crimat 25 mg Injection ; Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Crimat 25 mg Injection ; Your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Caution

Crimat 25 mg Injection causes sleepiness and drowsiness. So, avoid driving or operating heavy machinery after taking this medicine.

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Liver

Caution

Crimat 25 mg Injection should be used with caution in patients with liver diseases. Your doctor may adjust the dose of Crimat 25 mg Injection before prescribing.

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Kidney

Caution

Crimat 25 mg Injection should be used with caution in patients with kidney diseases. Your doctor may adjust the dose of Crimat 25 mg Injection before prescribing.

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Children

Caution

Crimat 25 mg Injection use is not recommended in neonates (children under the age of one month). Your doctor will decide the dose of Crimat 25 mg Injection based on age and condition of your child.

FAQs

Crimat 25 mg Injection is used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care.
Crimat 25 mg Injection contains 'Atracurium' that relaxes the muscles by blocking the impulses from the nerves. It is used for skeletal muscle relaxation during surgery.
Crimat 25 mg Injection causes sleepiness and drowsiness. So, drive only if you are alert and omit driving or operating machinery if you feel sleepy or drowsy.
Crimat 25 mg Injection is safe and effective when administered to patients with severe heart disease. However, rapid administration of large doses may occasionally produce transient hypotension in patients with heart problems. Please consult your doctor. Your doctor will prescribe only if the benefits outweigh the risks.
Do not use Crimat 25 mg Injection have had myasthenia gravis or Eaton-Lambert syndrome, severe electrolyte disorder, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns, and lack of adequate circulatory filling (hypovolaemia), pregnant or breastfeeding mother. Avoid driving or performing hazardous tasks until you know how Crimat 25 mg Injection will affect you, and your reactions could be impaired.
Crimat 25 mg Injection is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer or the fridge.
Crimat 25 mg Injection is given by IV injection administered by a healthcare professional under carefully controlled conditions. Do not self-administer Crimat 25 mg Injection .
The common side effects of the Crimat 25 mg Injection are tachycardia (rapid heartbeat), temporary hypotension (low blood pressure), wheezing, bronchospasm (asthma-like symptoms), skin flushing, and urticaria (nettle rash). However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

Country of origin

INDIA

Manufacturer/Marketer address

213, Shivai Dongre Industrial Premises, Andheri - Kurla Road, Andheri(E), Mumbai - 400 072, Maharashtra, India.
Other Info - CRI0060

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Keep Refrigerated. Do not freeze.

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