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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Atacurium 25 mg Injection is used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care. It contains Atracurium, which stops sending pain signal to the brain, relieves muscle stiffness or muscle spasm. It is also used during general anaesthesia to ease tracheal intubation (a tube into the windpipe) and controlled ventilation.
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Composition :

ATRACURIUM-25MG

Manufacturer/Marketer :

Themis Chemicals Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Atacurium 25 mg Injection

Atacurium 25 mg Injection belongs to the group of medicines called skeletal muscle relaxants used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms.

Atacurium 25 mg Injection contains ‘Atracurium’ that works by blocking the action of acetylcholine on skeletal muscles. Thus, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery. Atacurium 25 mg Injection is used during surgery.  It is also used during general anaesthesia to ease tracheal intubation (a tube into the windpipe) and controlled ventilation.

Atacurium 25 mg Injection is given by the healthcare professional during surgery.  In some cases, you may experience tachycardia (rapid heartbeat), temporary hypotension (low blood pressure), wheezing, bronchospasm (asthma-like symptoms), skin flushing, and urticaria (nettle rash). Most of these side effects of Atacurium 25 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before receiving Atacurium 25 mg Injection inform your doctor if you have had myasthenia gravis or Eaton-Lambert syndrome,  severe electrolyte disorder, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns and lack of adequate circulatory filling (hypovolaemia), pregnant or breastfeeding mother. Your doctor will prescribe Atacurium 25 mg Injection only if the benefits outweigh the risks. Atacurium 25 mg Injection is not recommended in neonates (children under the age of one month). Atacurium 25 mg Injection is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer or the fridge.

Uses of Atacurium 25 mg Injection

Treatment of Muscle contraction during surgery.

Directions for Use

A healthcare professional will administer Atacurium 25 mg Injection under carefully controlled conditions. Do not self-administer Atacurium 25 mg Injection .

Medicinal Benefits

Atacurium 25 mg Injection belongs to the group of medicines called muscle relaxants used to reduce and relieve muscle contraction (excessive tension in the muscles) during surgery, other procedures, and in intensive care. It is also used to calm muscles while on a breathing machine, during general anaesthesia to ease tracheal intubation (a tube into the windpipe), and controlled ventilation. It works by blocking the action of acetylcholine on skeletal muscles. Also, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery. An experienced doctor must give Atacurium 25 mg Injection under carefully controlled conditions. It is used during procedures that require that the patient is fully anaesthetized (unconscious) or heavily sedated.

How Atacurium 25 mg Injection Works

Atacurium 25 mg Injection contains ‘Atracurium’ that works by blocking the action of acetylcholine on skeletal muscles. Thus, stop sending a pain signal to the brain, relieving muscle stiffness or muscle spasm along with pain and surgery.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Atacurium 25 mg Injection

  • Tachycardia (rapid heartbeat)
  • Temporary hypotension (low blood pressure)
  • Wheezing
  • Bronchospasm (asthma-like symptoms)
  • Skin flushing
  • Urticaria (nettle rash)

What if I have taken an overdose of Atacurium 25 mg Injection

The overdose of Atacurium 25 mg Injection is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Atacurium 25 mg Injection , please inform your doctor immediately.

Drug Warnings

Before you receive Atacurium 25 mg Injection , tell your doctor if you have a disease that affects the muscles and nervous control (neuromuscular disease such as myasthenia gravis or Eaton-Lambert syndrome (muscle disorder)), a severe electrolyte disorder, cancer spread widely from a primary source (carcinomatosis), a sensitivity to histamine, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns, lack of adequate circulatory filling (hypovolaemia). Atacurium 25 mg Injection should not be given to pregnant women unless prescribed. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Atacurium 25 mg Injection . Mothers should stop breastfeeding for 24 hours after receiving Atacurium 25 mg Injection . Atacurium 25 mg Injection is not recommended in neonates (children under the age of one month) as safety and effectiveness in pediatric patients below the age of 1 month have not been established. Atacurium 25 mg Injection some formulations containing benzyl alcohol. In neonates, benzyl alcohol has been associated with an increased incidence of neurological and other complications, sometimes fatal.

Drug-Drug Interactions

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AtracuriumPolymyxin b
Severe
AtracuriumStreptomycin
Severe

Drug-Drug Interactions

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AtracuriumPolymyxin b
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Polymyxin B with Atacurium 25 mg Injection 2.5 ml may cause serious breathing problems

How to manage the interaction:
There may be a possibility of interaction between Polymyxin b and Atacurium 25 mg Injection 2.5 ml, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without a doctor's advice.
AtracuriumStreptomycin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Streptomycin with Atacurium 25 mg Injection 2.5 ml may increase the neuromuscular blocking effects of Atacurium 25 mg Injection 2.5 ml.

How to manage the interaction:
Co-administration of Streptomycin with Atacurium 25 mg Injection 2.5 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
AtracuriumAmikacin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Amikacin with Atacurium 25 mg Injection 2.5 ml can increase the risk of developing breathing difficulties.

How to manage the interaction:
Taking Atacurium 25 mg Injection 2.5 ml with Amikacin together can result in an interaction, but it can be taken if your doctor has advised it. Consult your doctor if you experience shortness of breath, palpitations, chest discomfort, or dizziness. Do not discontinue any medications without consulting a doctor.
AtracuriumDoxycycline
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Atacurium 25 mg Injection 2.5 ml with doxycycline may increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between Atacurium 25 mg Injection 2.5 ml and Doxycycline, bit it can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.
AtracuriumStreptomycin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Streptomycin with Atacurium 25 mg Injection 2.5 ml may increase the risk or severity of side effects.

How to manage the interaction:
Co-administration of Streptomycin with Atacurium 25 mg Injection 2.5 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
AtracuriumBotulinum toxin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Coadministration of Botulinum toxin with Atacurium 25 mg Injection 2.5 ml may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Botulinum toxin and Atacurium 25 mg Injection 2.5 ml, it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience excessive muscle weakness or trouble breathing, swallowing, or speaking. Do not discontinue any medications without consulting a doctor.
AtracuriumClindamycin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Co-administration of Clindamycin with Atacurium 25 mg Injection 2.5 ml can increase the risk of muscle weakness.

How to manage the interaction:
Taking Clindamycin with Atacurium 25 mg Injection 2.5 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. "Clindamycin can affect the muscles and nerves in your body. When used with other medications that also affect the muscles and nerves, it can cause a serious problem called neuromuscular blockade. If you have trouble breathing or can't breathe at all, please call your doctor right away." Do not stop using any medications without a doctor's advice.
AtracuriumColistin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Coadministration of Atacurium 25 mg Injection 2.5 ml with Colistin can increase the risk of Atacurium 25 mg Injection 2.5 ml side effects.

How to manage the interaction:
Although there is a possible interaction between Colistin and Atacurium 25 mg Injection 2.5 ml, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, slurred speech, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
AtracuriumTobramycin
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Using Atacurium 25 mg Injection 2.5 ml with Tobramycin can increase the risk of respiratory depression (breathing disorder).

How to manage the interaction:
Although there is a interaction between Tobramycin and Atacurium 25 mg Injection 2.5 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
AtracuriumFentanyl
Severe
How does the drug interact with Atacurium 25 mg Injection 2.5 ml:
Combining Atacurium 25 mg Injection 2.5 ml with Fentanyl can increase the risk of irregular heart rhythm and low blood pressure.

How to manage the interaction:
There may be a possibility of interaction between Atacurium 25 mg Injection 2.5 ml and Fentanyl, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid freezing and hot temperatures.

  • Avoid wearing tight-fitting clothes. Instead, wear loose garments.

  • Rest well, and get plenty of sleep.

  • To avoid developing pressure sores, change your position every two hours.

  • Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot pack on the muscle for 15-20minutes.

  • Stay hydrated, and drink plenty of water.

Habit Forming

No

Therapeutic Class

MUSCLE RELAXANTS/SKELETAL MUSCLE RELAXANTS

Atacurium 25 mg Injection Substitute

Substitutes safety advice
  • TRACRIUM 25MG INJECTION 2.5ML

    2.38per tablet
  • Crimat 25 mg Injection 2.5 ml

    by AYUR

    21.15per tablet
  • Arium 25 mg Injection 2.5 ml

    66.22per tablet
  • Atraplen 25 mg Injection 1's

    131.71per tablet
  • Skelatra 25mg Injection

    42.30per tablet
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Alcohol

Caution

Avoid consumption of alcohol after taking Atacurium 25 mg Injection as it may increase the risk of side effects.

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Pregnancy

Caution

If you are pregnant, inform your doctor before receiving Atacurium 25 mg Injection ; Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Atacurium 25 mg Injection ; Your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Caution

Atacurium 25 mg Injection causes sleepiness and drowsiness. So, avoid driving or operating heavy machinery after taking this medicine.

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Liver

Caution

Atacurium 25 mg Injection should be used with caution in patients with liver diseases. Your doctor may adjust the dose of Atacurium 25 mg Injection before prescribing.

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Kidney

Caution

Atacurium 25 mg Injection should be used with caution in patients with kidney diseases. Your doctor may adjust the dose of Atacurium 25 mg Injection before prescribing.

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Children

Caution

Atacurium 25 mg Injection use is not recommended in neonates (children under the age of one month). Your doctor will decide the dose of Atacurium 25 mg Injection based on age and condition of your child.

FAQs

Atacurium 25 mg Injection is used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care.
Atacurium 25 mg Injection contains 'Atracurium' that relaxes the muscles by blocking the impulses from the nerves. It is used for skeletal muscle relaxation during surgery.
Atacurium 25 mg Injection causes sleepiness and drowsiness. So, drive only if you are alert and omit driving or operating machinery if you feel sleepy or drowsy.
Atacurium 25 mg Injection is safe and effective when administered to patients with severe heart disease. However, rapid administration of large doses may occasionally produce transient hypotension in patients with heart problems. Please consult your doctor. Your doctor will prescribe only if the benefits outweigh the risks.
Do not use Atacurium 25 mg Injection have had myasthenia gravis or Eaton-Lambert syndrome, severe electrolyte disorder, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns, and lack of adequate circulatory filling (hypovolaemia), pregnant or breastfeeding mother. Avoid driving or performing hazardous tasks until you know how Atacurium 25 mg Injection will affect you, and your reactions could be impaired.
Atacurium 25 mg Injection is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer or the fridge.
Atacurium 25 mg Injection is given by IV injection administered by a healthcare professional under carefully controlled conditions. Do not self-administer Atacurium 25 mg Injection .
The common side effects of the Atacurium 25 mg Injection are tachycardia (rapid heartbeat), temporary hypotension (low blood pressure), wheezing, bronchospasm (asthma-like symptoms), skin flushing, and urticaria (nettle rash). However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

Country of origin

INDIA

Manufacturer/Marketer address

11/12, Udyog Nagar, S. V. Road, Goregaon (W), Mumbai- 400104.
Other Info - ATA0031

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Keep Refrigerated. Do not freeze.Prepaid payment required.

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