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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 30, 2024 | 5:51 AM IST

Comedolytic Cream is used to treat acne (pimples) and sun-damaged skin. It contains Tretinoin, (a form of vitamin A) that loosens and unblocks pores on the skin's surface by reducing the oil secretion in the skin. This prevents the formation of pimples, whiteheads, and blackheads. Some people may experience side effects such as dry skin, peeling, redness, burning, itching, or stinging sensation of the skin. Avoid sun exposure while using this medicine, as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use a sunscreen lotion while going out to protect your skin from sunburn.

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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Dabur India Ltd

Consume Type

TOPICAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Comedolytic Cream

Comedolytic Cream is used to treat acne (pimples) and sun-damaged skin. Acne is a skin condition that is common and occurs when hair follicles are blocked with dead skin cells and oil.

Comedolytic Cream contains tretinoin, also known as retinoic acid (a form of vitamin A), that loosens and unblocks pores on the skin’s surface by reducing the oil secretion in the skin. This prevents the formation of pimples, whiteheads, and blackheads.

Comedolytic Cream is for external use only. Your doctor will advise you on how often you use Comedolytic Cream based on your medical condition. Avoid contact of Comedolytic Cream with nose, mouth, eyes, ears, or vagina. In case Comedolytic Cream comes in contact with these areas accidentally, rinse with water thoroughly. Some people may experience dry skin, peeling, redness, burning, itching, or stinging sensation of the skin. Most of these side effects of Comedolytic Cream do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Comedolytic Cream or any other medicines, please tell your doctor. If you are pregnant, a nursing mother, or planning for pregnancy, it is advised to consult a doctor before using Comedolytic Cream. Avoid sun exposure while using Comedolytic Cream as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use a sunscreen lotion (SPF) while going out to protect your skin from sunburn. Do not apply Comedolytic Cream in larger amounts than prescribed, as it does not give quick or better results but causes peeling, marked redness, or skin discomfort. Patients with a history of depression, eczema, history of skin cancer, and fish allergies should use Comedolytic Cream with caution.

Uses of Comedolytic Cream

Treatment of Acne, Wrinkles

Medicinal Benefits

Comedolytic Cream is a form of vitamin A (retinoid) that loosens and unblocks pores on the skin’s surface by reducing the oil secretion in the skin. This prevents the formation of pimples, whiteheads, and blackheads.

Directions for Use

Wash your hands before and after applying Comedolytic Cream. Before using it, try to clean and dry the affected skin area. Applying Comedolytic Cream to wet skin may cause skin irritation, so try not to wash the treated area. Also, do not apply other skin products for at least 1 hour after applying Comedolytic Cream. Wash the face with mild soap and pat the skin dry. Take a small pearl-sized amount of Comedolytic Cream on the fingertip and apply it on the clean and dry affected area once a day in the evening. Avoid contact of Comedolytic Cream with nose, mouth, eyes, ears or vagina. In case Comedolytic Cream comes in contact with these areas accidentally, rinse with water thoroughly.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Comedolytic Cream

  • Dry skin
  • Peeling
  • Skin redness
  • Burning
  • Itching
  • Stinging sensation

Drug Warnings

If you are allergic to tretinoin or any other medicines, please inform your doctor. If skin irritation, redness, burning, or stinging sensation worsens at the site of application, stop using Comedolytic Cream and consult a doctor. If you are pregnant, planning for pregnancy, or are a nursing mother, it is advised to consult a doctor before using Comedolytic Cream. Avoid sun exposure, use a sunscreen lotion and wear protective clothing while going out in the sun as Comedolytic Cream may make the skin more sensitive to the sun. Do not apply Comedolytic Cream in large amounts than prescribed as it does not give quick or better results but causes peeling, marked redness, or skin discomfort. Use Comedolytic Cream with caution when used together with medicated or abrasive soaps, cleansers, shampoos, astringents, products with high concentrations of alcohol, electrolysis, hair depilatories, or waxes or topical medications as they may increase skin irritation.

Drug Interactions

Drug-Drug Interaction: Comedolytic Cream may interact with vitamin A-related drugs known as retinoids (isotretinoin), photosensitizing agents (aminolevulinic acid, methoxsalen, porfirmer, verteporfin), sensitizer (methyl aminolevulinate), keratolytic agents (benzoyl peroxide, salicylic acid, sulfur), antiseptic (resorcinol).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have eczema (itchy, swelling of the skin) or any other skin condition, inform your doctor before taking Comedolytic Cream.

Drug-Drug Interactions Checker List

  • ISOTRETINOIN
  • AMINOLEVULINIC ACID
  • METHOXSALEN
  • PORFIRMER
  • VERTEPORFIN
  • METHYL AMINOLEVULINATE
  • BENZOYL PEROXIDE
  • SALICYCLIC ACID
  • SULFUR
  • RESORCINOL

Habit Forming

No

Diet & Lifestyle Advise

  • Avoid sun exposure while using Comedolytic Cream as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn.
  • Regular exercise can improve your mood and self-esteem, though it doesn’t clear acne. Take a shower immediately after finishing exercise as sweat may irritate acne.
  • Do regular hair wash and avoid hair falling across the face.
  • Use water-based cosmetic products and remove the makeup completely before going to bed.

Special Advise

  • ​​​​​​Do not apply Comedolytic Cream in larger amounts than prescribed, as this does not give quick or better results but causes peeling, marked redness, or skin discomfort.
  • Do not squeeze spots or try to clean blackheads, as it may worsen them and cause permanent scarring.

Disease/Condition Glossary

Acne: Acne is a common skin condition that occurs when hair follicles are blocked with dead skin cells and oil, causing pimples, whiteheads and blackheads. Acne affects people of all ages but is most common among teenagers. The symptoms of acne include pus-filled pimples, uninflamed (not swollen) blackheads, and red, large and tender bumps.

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Alcohol

Caution

Interaction of alcohol with Comedolytic Cream is unknown. Please consult a doctor before consuming alcohol while using Comedolytic Cream.

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Pregnancy

Unsafe

Comedolytic Cream is Category C pregnancy drug and is considered unsafe for pregnant women. Therefore, if you are pregnant, inform your doctor before using Comedolytic Cream.

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Breast Feeding

Caution

It is unknown whether Comedolytic Cream is excreted in human milk. Please consult a doctor before using Comedolytic Cream while breastfeeding.

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Driving

Safe if prescribed

Comedolytic Cream usually does not affect your ability to drive or operate machinery.

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Liver

Caution

If you have any concerns regarding the use of Comedolytic Cream in patients with liver problems, please consult a doctor.

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Kidney

Caution

If you have any concerns regarding the use of Comedolytic Cream in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Comedolytic Cream is not recommended for children below 18 years as the safety and effectiveness were not established.

Country of origin

India

Manufacturer/Marketer address

d-55, midc, ambad nasik, maharashtra, india
Other Info - COM0108

Author Details

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FAQs

Comedolytic Cream is primarily used to treat acne (pimples) and sun-damaged skin.
Comedolytic Cream may increase the skin sensitivity to sunlight in the treated areas. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen with a minimum SPF 15 and wear protective clothing while going out to prevent sunburn.
You are recommended to use cosmetics after 1 hour of applying Comedolytic Cream but avoid cosmetics with a strong drying effect as they may increase skin irritation. If you are using any cosmetics, clean your face before applying Comedolytic Cream again.
Yes, Comedolytic Cream may cause skin irritation, burning sensation or itching at the site of application. Extreme weather conditions such as cold or wind may cause more irritation in patients using Comedolytic Cream containing products. However, if the irritation worsens, stop using Comedolytic Cream and consult a doctor.
You are advised to use moisturizers in the morning every day to prevent dryness in the treated areas.
Comedolytic Cream does not remove wrinkles completely or repair skin damaged by the sun. Comedolytic Cream may reduce fine wrinkles, especially when used along with other skincare products.
You are recommended to use Comedolytic Cream for as long as your doctor has prescribed it. However, the course of treatment with Comedolytic Cream takes up to 6 months for effective results.
Acne is a skin condition that is common and occurs when hair follicles are blocked with dead skin cells and oil.
Comedolytic Cream increases cell turnover on your skin, which can promote new cell growth at the site of your scarring. As a result, it may help to reduce acne scars.
Limited research available. So, seek medical attention from your dermatologist.
Comedolytic Cream can be a safe, effective treatment option for acne.
Comedolytic Cream is Category C pregnancy drug and is considered unsafe for pregnant women. Therefore, if you are pregnant, inform your doctor before using Comedolytic Cream.
Skin peeling occurs for a variety of reasons. First, tretinoin is an exfoliator. When you apply tretinoin gel or cream to your face, your body speeds up the rate at which it replaces old skin with new skin, shedding the old layer of skin in the process. Second, tretinoin can increase your skin’s sensitivity to sunlight, making it more likely that your facial skin could become sunburned and peel off naturally after sun exposure. Using a moisturizer and avoiding sunlight exposure is recommended to manage skin peeling.

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