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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 30, 2024 | 3:23 PM IST
Combinase AQ Nasal Spray 70 mdi is used to treat allergic symptoms like sneezing, runny nose, congestion, stuffy nose, or watery eyes. It contains Fluticasone propionate and Azelastine, which works by acting inside cells of the nasal lining and stops the release of certain chemicals in the body that cause inflammatory reactions thereby relieving sneezing, runny or blocked nose, and sinus discomfort. Also, it blocks the action of histamine, a substance responsible for causing allergic reactions. Some people may experience side effects such as headache, taste changes, or nose bleeds. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer

Zydus Cadila

Consume Type

NASAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Combinase AQ Nasal Spray 70 mdi

Combinase AQ Nasal Spray 70 mdi belongs to the class of medications called 'anti-allergic' primarily used to treat allergic symptoms like sneezing, runny nose, congestion, stuffy nose, or watery eyes. An allergy is a condition that occurs when the immune system reacts to a foreign substance that is typically not harmful to your body. These foreign substances are known as ‘allergens.’ Allergic condition varies from person to person. Some might be allergic to certain foods and seasonal allergies like hay fever, pollen, or pet dander. One of the main symptoms of allergy is cough, and it acts as a reflex action in the throat when there is any mucus or foreign irritant entry into the respiratory system.

Combinase AQ Nasal Spray 70 mdi is a combination of two drugs, namely: Fluticasone propionate (corticosteroid) and Azelastine (antihistamine/antiallergic). Fluticasone propionate belongs to the class of corticosteroids that works by acting inside cells of the nasal lining and stops the release of certain chemicals in the body that cause inflammatory reactions thereby relieving sneezing, runny or blocked nose, and sinus discomfort. On the other hand, Azelastine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions.  It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.

Use Combinase AQ Nasal Spray 70 mdi as prescribed. Your doctor will recommend how often you take Combinase AQ Nasal Spray 70 mdi based on your medical condition. Some people may experience headache, taste changes, or nose bleeds. Most of these side effects of Combinase AQ Nasal Spray 70 mdi do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Combinase AQ Nasal Spray 70 mdi or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Combinase AQ Nasal Spray 70 mdi. Combinase AQ Nasal Spray 70 mdi is not recommended for children below 6 years of age. If you experience any changes in vision, tiredness, nausea, vomiting, light-headedness, chills, fever, body pains, sores, redness or white patches in the mouth or throat, runny nose, severe nosebleeds, or increased drowsiness, stop taking Combinase AQ Nasal Spray 70 mdi and consult a doctor immediately. Avoid contact with people who have infections or who are sick as Combinase AQ Nasal Spray 70 mdi may weaken the immune system causing infections easily. If you have chickenpox, measles, tuberculosis, surgery or injury on the nose, glaucoma, cataracts, herpes infection of the eyes, ulcers or sores inside the nose, inform your doctor before taking Combinase AQ Nasal Spray 70 mdi.

Uses of Combinase AQ Nasal Spray 70 mdi

Treatment of Allergic symptoms.

Medicinal Benefits

Combinase AQ Nasal Spray 70 mdi is a combination of two drugs, namely: Fluticasone propionate and Azelastine used to treat allergic symptoms such as sneezing, runny nose, congestion, stuffy nose, or watery eyes. Fluticasone propionate belongs to the class of corticosteroids that works by acting inside cells of the nasal lining. It stops the release of certain chemicals in the body that cause inflammatory reactions, thereby providing relief from sneezing, runny or blocked nose, and sinus discomfort. Azelastine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions.  It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness. Together Combinase AQ Nasal Spray 70 mdi relieves allergic symptoms, including seasonal allergies, and reduces inflammation of nasal passage.

Directions for Use

Use Combinase AQ Nasal Spray 70 mdi as prescribed by your doctor. Check the label for directions before using Combinase AQ Nasal Spray 70 mdi. Insert the tip of the bottle into a nostril while closing the other nostril and spray Combinase AQ Nasal Spray 70 mdi towards the sides of the nostril. Keep your head straight and breathe gently. Repeat the same process for another nostril.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Combinase AQ Nasal Spray 70 mdi

  • Headache
  • Taste change
  • Nose bleeds

Drug Warnings

If you are allergic to Combinase AQ Nasal Spray 70 mdi or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Combinase AQ Nasal Spray 70 mdi. Combinase AQ Nasal Spray 70 mdi is not recommended for children below 6 years of age. If you experience any changes in vision, tiredness, nausea, vomiting, light-headedness, chills, fever, body pains, sores, redness or white patches in the mouth or throat, runny nose, severe nosebleeds, or increased drowsiness, stop taking Combinase AQ Nasal Spray 70 mdi and consult a doctor immediately. Avoid contact with people who have infections or who are sick as Combinase AQ Nasal Spray 70 mdi may weaken the immune system causing infections easily. If you have chickenpox, measles, tuberculosis, surgery or injury on the nose, glaucoma, cataracts, herpes infection of the eyes, ulcers or sores inside the nose, inform your doctor before taking Combinase AQ Nasal Spray 70 mdi.

Drug Interactions

Drug-Drug Interaction: Combinase AQ Nasal Spray 70 mdi may interact with antidepressants (duloxetine, escitalopram), anticonvulsants (pregabalin), HIV/AIDS drug (ritonavir), antifungals (ketoconazole, fluconazole, itraconazole) and anti-allergy drugs (cetirizine).

Drug-Food Interaction: Combinase AQ Nasal Spray 70 mdi may interact with grapefruit juice. Therefore, avoid intake of grapefruit juice with Combinase AQ Nasal Spray 70 mdi as it may lead to adrenal insufficiency and Cushing’s syndrome. Also, avoid consumption of alcohol with Combinase AQ Nasal Spray 70 mdi as it may cause increased drowsiness, dizziness, impairment of judgement, and thinking.

Drug-Disease Interaction: If you have chickenpox, measles, tuberculosis, surgery or injury on the nose, glaucoma, cataracts, herpes infection of the eyes, ulcers or sores inside the nose, inform your doctor before taking Combinase AQ Nasal Spray 70 mdi.

Drug-Drug Interactions Checker List

  • DULOXETINE
  • ESCITALOPRAM
  • PREGABALIN
  • RITONAVIR
  • KETOCONAZOLE
  • FLUCONAZOLE
  • ITRACONAZOLE
  • CETIRIZINE

Habit Forming

No

Diet & Lifestyle Advise

  • Add ginger to foods or tea as it contains some anti-inflammatory compounds that can relax membranes in the airways and reduce cough, irritation and swelling in nasal passages.
  • Staying hydrated is vital for those with a cough or cold. Drink liquids at room temperature to get relief from a runny nose, cough, and sneezing.
  • The immune system is affected by stress and raises the risk of being sick. Do meditation, deep breathing, regular exercise and try progressive muscle relaxation techniques to get relief from stress.
  • It is advised to avoid contact with known allergens (allergy-causing agents) such as pollen, dust, etc. Certain food items are known to cause allergies to you.
  • Maintain personal hygiene and keep your surroundings clean.

Special Advise

Certain blood tests are recommended while taking Combinase AQ Nasal Spray 70 mdi to monitor serum cortisol levels as Combinase AQ Nasal Spray 70 mdi may increase these levels.

Disease/Condition Glossary

Allergy: It is a condition that occurs when the immune system reacts to a foreign substance that is typically not harmful to your body. These foreign substances are known as ‘allergens.’ Allergic condition varies from person to person. Some might be allergic to certain foods and seasonal allergies like hay fever, pollen, or pet dander. One of the main symptoms of allergy is cough, and it acts as a reflex action in the throat when there is any mucus or foreign irritant entry into the respiratory system.

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Alcohol

Unsafe

Avoid consumption of alcohol with Combinase AQ Nasal Spray 70 mdi as it may increase adverse effects. Please consult a doctor before consuming alcohol with Combinase AQ Nasal Spray 70 mdi.

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Pregnancy

Caution

The safety of Combinase AQ Nasal Spray 70 mdi in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks benefits outweigh risks.

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Breast Feeding

Caution

It is unknown whether Combinase AQ Nasal Spray 70 mdi is excreted in human milk. It is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Caution

Combinase AQ Nasal Spray 70 mdi may cause drowsiness in some people. Therefore, drive only if you are alert after taking Combinase AQ Nasal Spray 70 mdi.

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Liver

Safe if prescribed

If you have any concerns regarding the use of Combinase AQ Nasal Spray 70 mdi in patients with Liver problems, please consult a doctor.

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Kidney

Safe if prescribed

If you have any concerns regarding the use of Combinase AQ Nasal Spray 70 mdi in patients with Kidney problems, please consult a doctor.

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Children

Caution

Combinase AQ Nasal Spray 70 mdi is not recommended for children below 6 years as the safety and effectiveness were not established.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad – 380015, Gujarat, India.
Other Info - COM0011

Author Details

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FAQs

Combinase AQ Nasal Spray 70 mdi is used to treat allergic symptoms like sneezing, runny nose, congestion, stuffy nose, or watery eyes.
Combinase AQ Nasal Spray 70 mdi contains Fluticasone propionate and Azelastine. Fluticasone propionate is a corticosteroid that works by acting inside cells of the nasal lining and stops the release of certain chemicals in the body that cause inflammatory reactions. Thereby, provides relief from sneezing, runny or blocked nose and sinus discomfort. Azelastine is an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.
You are recommended to avoid taking grapefruit juice with Combinase AQ Nasal Spray 70 mdi as they may lead to adrenal insufficiency and Cushing’s syndrome.
No, you are not recommended to consume alcohol with Combinase AQ Nasal Spray 70 mdi as it may cause increased drowsiness, dizziness, impairment of judgement and thinking. However, please consult a doctor before consuming alcohol with Combinase AQ Nasal Spray 70 mdi.
Combinase AQ Nasal Spray 70 mdi is not recommended for children below 6 years as the safety and effectiveness were not established. However, please consult a doctor before using Combinase AQ Nasal Spray 70 mdi in children.
Yes, Combinase AQ Nasal Spray 70 mdi may cause drowsiness in some people, especially in people consuming alcohol with Combinase AQ Nasal Spray 70 mdi. It is not necessary for everyone taking Combinase AQ Nasal Spray 70 mdi to experience this side effect. Therefore, avoid driving if you feel drowsy after taking Combinase AQ Nasal Spray 70 mdi.
You are not recommended to take more than the prescribed dose of Combinase AQ Nasal Spray 70 mdi or for a prolonged time as it may cause adverse effects such as changes in body fat (especially in the back, waist, neck and face), easy bruising, skin thinning, increased facial hair or acne, loss of interest in sex, impotence or menstrual problems. However, if you experience any of these symptoms while taking Combinase AQ Nasal Spray 70 mdi, please consult a doctor immediately.
No, Combinase AQ Nasal Spray 70 mdi is not used to treat asthma attacks. Combinase AQ Nasal Spray 70 mdi is used to prevent allergic symptoms that can cause asthma. Therefore, it is recommended to carry a rescue inhaler always to treat asthma attacks.
No, you are not recommended to stop taking Combinase AQ Nasal Spray 70 mdi without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Combinase AQ Nasal Spray 70 mdi for as long as your doctor has prescribed it, and if you experience any difficulty while taking Combinase AQ Nasal Spray 70 mdi, please consult your doctor.
You should avoid taking Combinase AQ Nasal Spray 70 mdi and consult a doctor before using Combinase AQ Nasal Spray 70 mdi if you have had any recent nose problems (like nose bleed, nose injury, nose ulcers, or nose surgery), infections like tuberculosis (TB), eye problems like herpes eye infection, glaucoma, or cataracts.
Shake the bottle gently for 5 seconds by tilting it upwards and downwards and then remove the protective cap. Blow your nose to clear your nostrils. Keep your head straight and hold the bottle upright insert the tip of the bottle into a nostril while closing the other nostril with your finger and rapidly press down once and sniff gently at the same time. Repeat the same process for another nostril. Breathe out through your mouth. Follow the dosage and frequency as prescribed by your doctor.
Store Combinase AQ Nasal Spray 70 mdi at room temperature in a cool and dry place. Away from excess heat and moisture. Keep out of reach of children. Do not refrigerate.
The common side effects of Combinase AQ Nasal Spray 70 mdi are headache, taste changes, or nose bleeds. If any of these side effects persist or worsen, please consult your doctor.

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