Cizorest-50 Tablet belongs to a group of medicines called 'antipsychotics' primarily used to treat long term (chronic) schizophrenia and postoperative nausea/vomiting. Schizophrenia is characterized by hallucinations symptoms (seeing or hearing things that are not real) and delusions (wrong beliefs). In schizophrenic disorders, there are positive symptoms (like delusions, hallucinations and thought disorders) along with negative symptoms (like blunted effect, emotional and social withdrawal). Nausea is an uneasy feeling in which the person feels an urge to vomit, whereas vomiting is an uncontrollable reflex that expels the stomach's contents through the mouth.

Cizorest-50 Tablet contains Amisulpride, which helps restore the balance of certain natural substances in the brain. The key action of Cizorest-50 Tablet is to block some of the dopamine receptors in the brain and correct dopamine's overactivity. On the other hand, it also affects other brain neurotransmitters such as serotonin (5-HT), which may also lead to its beneficial effects. Cizorest-50 Tablet also stops the sensation of vomiting/nausea by blocking the D2 receptors located in the chemoreceptor trigger zone - CTZ of the brain responsible for inducing vomiting.

Cizorest-50 Tablet can be taken with or without food as prescribed by your doctor. You are advised to take Cizorest-50 Tablet for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain side effects such as dryness in the mouth, constipation, weight gain, decreased blood pressure, dystonia (involuntary muscle contractions), akathisia (inability to stay still), parkinsonism, increased prolactin level in blood. Most of these side effects of Cizorest-50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist for a longer duration, consult your doctor immediately.

Cizorest-50 Tablet should be avoided if you are allergic to it or any other medicines. Cizorest-50 Tablet is not recommended for children below 18 years of age. If you are pregnant or breastfeeding, inform your doctor before taking Cizorest-50 Tablet . Use Cizorest-50 Tablet with extreme caution in elderly patients above 65 years of age as there is an increased risk of severe adverse effects.  If you have breast cancer, pheochromocytoma (tumor of the adrenal gland), pituitary gland prolactinoma (tumor of the pituitary gland), fits, Parkinson’s disease, kidney or heart problems, inform your doctor before taking Cizorest-50 Tablet . Avoid driving and op taking Cizorest-50 Tablet as it may cause drowsiness or dizziness.

Cizorest-50 Tablet contains Amisulpride, a group of medicines called antipsychotics used to treat a mental illness called schizophrenia and bipolar disorder. Additionally, Cizorest-50 Tablet has anti-emetics properties used either in monotherapy or in combination with other antiemetic drugs to prevent nausea and vomiting, which might occur after surgery. The key action of Cizorest-50 Tablet is to block some of the brain's dopamine receptors and correct dopamine's overactivity, thereby producing a calming effect in the brain. Altogether, Cizorest-50 Tablet may help decrease hallucinations and help you think more clearly and positively about yourself, feel less agitated and take a more active part in everyday life. 

• Dizziness

• Drowsiness 
• Difficulty sleeping (insomnia) or feeling anxious or agitated
• Lightheadedness
• Blurred vision
• Dry mouth
• Constipation
• Weight gain
• Decreased blood pressure
• Dystonia (involuntary muscle contractions)
• Akathisia (inability to stay still)
• Parkinsonism
• Breast enlargement in men
• Unusual production of breast milk in women and men, breast pain
• High blood sugar (hyperglycaemia)

• Do not take Cizorest-50 Tablet if you are allergic (hypersensitive) to amisulpride or any other ingredients present in this medicine or have a medical history of prolactin-dependent tumor or breast cancer, phaeochromocytoma (a tumor on the adrenal gland), pituitary tumor.

• Cizorest-50 Tablet should not be given to children as safety has not been established.

• Use Cizorest-50 Tablet with extreme caution in elderly patients above 65 years of age as there is an increased risk of severe adverse effects.

• If you are pregnant or breastfeeding, please consult a doctor before taking Cizorest-50 Tablet . Cizorest-50 Tablet may impair fertility, so inform your doctor if you are planning for pregnancy.

• Inform your doctor if you are previously diagnosed with kidney disease, liver disease epilepsy or seizures (fits), Parkinson's disease, unusual heart rate (rhythm), slow heartbeat (less than 55 beats per minute), low potassium levels in your blood, prolonged QT interval (heart conduction problem), if you or someone else in your family has a history of blood clots, heart problems, stroke, diabetes, have a low number of white blood cells (agranulocytosis), leucopenia (blood disorder).

• Cizorest-50 Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Cizorest-50 Tablet as it could lead to increased drowsiness and dizziness.  

Drug-Drug Interaction: Cizorest-50 Tablet may have interaction with medicines used to reduce heart rate (quinidine, disopyramide, amiodarone, sotalol) medicines for high blood pressure and heart problems (diltiazem, verapamil, guanfacine, digitalis, clonidine, bepridil) pain killers (morphine, pethidine, tramadol, indomethacin, aspirin, acetaminophen, hydrocodone) antimalarial (mefloquine), anti-histamines (promethazine, diphenhydramine), medicine used to treat schizophrenia (clozapine), neuroleptics (pimozide, haloperidol, imipramine, duloxetine, citalopram, sertraline, fluoxetine, paroxetine), anti-anxiety drugs (lorazepam and diazepam), antipsychotics (flupentixol, droperidol, haloperidol, fluphenazine, pipamperone), antibiotics (ciprofloxacin, erythromycin, sparfloxacin, moxifloxacin), antiparkinson (levodopa, ropinirole, bromocriptine).

Drug- Food Interaction: Cizorest-50 Tablet may interact with grapefruit juice and alcohol. Therefore, avoid intake of grapefruit juice and alcohol with Cizorest-50 Tablet as it may increase the risk of adverse effects.

Drug-Disease Interaction: If you have breast cancer, pheochromocytoma (tumour of the adrenal gland), pituitary gland prolactinoma (tumour of the pituitary gland), fits, Parkinson’s disease, kidney or heart problems, inform your doctor before taking Cizorest-50 Tablet .

• QUINIDINE
• DISOPYRAMIDE
• AMIODARONE
• SOTALOL
• DILTIAZEM
• VERAPAMIL
• DIGITALIS
• CLONIDINE
• BEPRIDIL
• MORPHINE
• PETHIDINE
• TRAMADOL
• INDOMETHACIN
• ASPIRIN
• ACETAMINOPHEN
• HYDROCODONE
• MEFLOQUINE
• PROMETHAZINE
• DIPHENHYDRAMINE
• CLOZAPINE
• PIMOZIDE
• HALOPERIDOL
• IMIPRAMINE
• LORAZEPAM
• DIAZEPAM
• FLUPENTIXOL
• DROPERIDOL
• FLUPHENAZINE
• PIPAMPERONE
• DULOXETINE
• CITALOPRAM
• SERTRALINE
• FLUOXETINE
• PAROXETINE
• CIPROFLOXACIN
• ERYTHROMYCIN
• SPARFLOXACIN
• MOXIFLOXACIN
• LEVODOPA
• ROPINIROLE
• BROMOCRIPTINE

Mental illness:

• Monitor your mood. Keep track of your mood regularly, including factors such as sleep, medicine and activities that can impact your mood. 

• Exercise daily. Exercise is nice to relieve tension. It can also avoid the weight gain that can be a side effect of your bipolar medication.

• You may also practice calming techniques such as meditation and deep breathing exercises.

• Get some normal sleep. Having enough sleep will help to stabilize your mood.

• Eat a healthy diet. Certain foods may affect your mood more than others. Consider keeping a food log to track what you eat and how certain foods make you feel. Talk to your doctor or nutritionist about foods that may help stabilize your mood.

• Stay optimistic. It will take time for your symptoms to improve after you start bipolar therapy, but you will feel relaxed knowing that you will get better and that the worst is most definitely behind you.

Nausea/Vomiting:

• Eat smaller meals more often.

• Drink fluids to stay hydrated. Use oral rehydration solutions (ORS) to replace lost electrolytes.

• Avoid solid foods until vomiting stops.

• Avoid foods that might cause stomach upset.

• Take ample rest. Avoid any activity immediately after eating.

• Consume plain, light foods such as bread and biscuits.

• Avoid food with strong flavours and fried food.

• Ginger tea might help in proper digestion.

• Cizorest-50 Tablet is not recommended for use in the children below 18 years of age. 

• Cizorest-50 Tablet should be used with caution in the older patient (above 65 years) and Parkinson's patient. 

Schizophrenia (psychosis): It is a mental illness in which brain information processing is affected. Patients with schizophrenia develop symptoms such as hallucinations (seeing or hearing unreal things), delusions (false beliefs) and become withdrawn from society. They lose the ability to differentiate reality from false beliefs. Schizophrenia and bipolar disorder may occur due to genetic factors, alcohol or drug abuse, or mental trauma. Schizophrenia may also occur due to traumatic brain injuries or other diseases.

Bipolar disorder: Patients with bipolar disorders have mood swings ranging from manic episodes of heightened excitement to severe depression. It used to be known as manic depression.

Nausea/Vomiting: It is an uneasy feeling in which the person feels an urge to vomit, whereas vomiting is an uncontrollable reflex that expels the stomach's contents through the mouth. Nausea and vomiting may occur separately or together. The common causes include motion sickness, emotional stress, indigestion, food poisoning, high fever or overeating. Nausea/vomiting might occur as an unpleasant effect of therapy, such as chemotherapy and radiation therapy. It is essential to control vomiting and nausea in cancer patients for performing everyday activities of the day. If not controlled, it can lead to mental changes, loss of appetite, malnutrition and dehydration.