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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Buvalor 10mcg H Injection is used to treat opioid dependence (addiction to opioid drugs). It contains Buprenorphine which prevents withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It may also provide pain relief by acting on specific receptors in the brain. This medicine may sometimes cause side effects such as dry mouth, vomiting, blurred vision, constipation, dizziness, tiredness and injection site reactions. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

BUPRENORPHINE-10MCG

Manufacturer/Marketer :

Modi Mundipharma Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Buvalor 10mcg H Injection

Buvalor 10mcg H Injection belongs to a class of drugs called 'opioid analgesic' primarily used to treat opioid addiction (narcotics) like morphine, heroin, etc. In some cases, it is also used to treat, prevent and treat moderate to severe pain. Drug addiction, also called substance use disorder, is a disease that affects a person's brain and behaviour and leads to an inability to control the use of a legal or illegal drug or medication.

Buvalor 10mcg H Injection contains 'Buprenorphine', an opioid partial agonist-antagonists that prevent withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It has been approved for the treatment of narcotic-use disorders. A combination of buprenorphine and naloxone is prescribed for use in the treatment of opioid dependence. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain.

Buvalor 10mcg H Injection will be administered by a trained healthcare professional. Hence, do not self-administer. This medicine may cause certain side effects such as dry mouth, vomiting, blurred vision, constipation, dizziness, tiredness and injection site reactions. Most of these side effects of Buvalor 10mcg H Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Buvalor 10mcg H Injection should be avoided if you are allergic to it. Do not use Buvalor 10mcg H Injection if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. This medicine is not recommended for children below 18 years of age. Buvalor 10mcg H Injection is a habit-forming drug, and there is a risk of dependence on Buvalor 10mcg H Injection. Hence, do not stop receiving Buvalor 10mcg H Injection without consulting a doctor as it may cause withdrawal symptoms like anxiety, increased heart rate, tremors or general unwell feeling. Buvalor 10mcg H Injection may decrease fertility in men and women. Do not consume alcohol with Buvalor 10mcg H Injection as it may increase the risk of side effects. Inform your doctor if you have respiratory disorders, heart diseases, high blood pressure, and liver or kidney disease before starting treatment with Buvalor 10mcg H Injection.

Uses of Buvalor 10mcg H Injection

Treatment of Opioid (drug) addiction, Pain.

Directions for Use

Buvalor 10mcg H Injection will be administered by a trained healthcare professional. Do not self-administer.

Medicinal Benefits

The Buvalor 10mcg H Injection contains Buprenorphine as a substitution (replacement) treatment in patients addicted to opioid drugs (heroin and morphine, etc.). It prevents or reduces the unpleasant withdrawal symptoms experienced when addicts stop using opioid drugs. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain. Compared to other opioid analgesics like methadone, Buvalor 10mcg H Injection has the advantage of having less sedation (sleepiness), decreased respiratory depression, decreased risk of diversion, fewer withdrawal symptoms and lower risk of toxicity at higher doses. 

How Buvalor 10mcg H Injection Works

Buvalor 10mcg H Injection contains 'Buprenorphine', an opioid partial agonist-antagonists that prevent withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It has been approved for the treatment of narcotic-use disorders. A combination of buprenorphine and naloxone is prescribed for use in the treatment of opioid dependence. It also provides pain relief by acting on specific receptors in the brain and helps in relieving pain.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Buvalor 10mcg H Injection

  • Weakness
  • Nervousness
  • Dizziness
  • Headache
  • Orthostatic hypotension (a sudden dip of blood pressure on standing)
  • Constipation
  • Diarrhea
  • Nausea
  • Vomiting
  • Sweating
  • Injection site reactions

What if I have taken an overdose of Buvalor 10mcg H Injection

Overdose of Buvalor 10mcg H Injection may cause narrowing or widening of the pupils (black circles in the centre of the eye), slowed/shallow/difficulty breathing, extreme sleepiness or drowsiness, unable to respond or wake up, coma (loss of consciousness for a period of time), and slow heartbeat. Since Buvalor 10mcg H Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any of these symptoms.

Drug Warnings

Please do not stop receiving Buvalor 10mcg H Injection suddenly, as it may cause withdrawal symptoms. Avoid frequent or high doses as it may lead to addiction. If you are known to be allergic to Buvalor 10mcg H Injection or any other medicines, please tell your doctor.  Do not use Buvalor 10mcg H Injection if you are pregnant or breastfeeding, as it may cause adverse effects on the baby. Buvalor 10mcg H Injection is not recommended for children below 18 years of age.  Avoid consuming alcohol with Buvalor 10mcg H Injection as it may increase the risk of side effects. Do not use this medicine if you have used an MAO inhibitor (antidepressants) in the past 14 days, as a dangerous drug interaction could occur. Buvalor 10mcg H Injection should be used with extreme caution in patients who have a history of alcoholism or drug abuse. Inform your doctor if you have severe breathing problems, asthma, delirium tremens (confusion and shaking after stopping drinking alcohol), hallucinations (seeing and hearing things that are not there), kidney or liver problems, head injury or brain disease, low blood pressure, urinary disorders (especially linked to enlarged prostate), thyroid problems, adrenocortical disorder (Addison’s disease), depression or other conditions that are treated with antidepressants. 

Drug-Drug Interactions

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BuprenorphineAlvimopan
Critical
BuprenorphineZiprasidone
Critical

Drug-Drug Interactions

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BuprenorphineAlvimopan
Critical
How does the drug interact with Buvalor 10mcg H Injection 2's:
Using alvimopan together with Buvalor 10mcg H Injection 2's can cause side effects (abdominal pain, nausea, vomiting, and diarrhea).

How to manage the interaction:
Taking Alvimopan with Buvalor 10mcg H Injection 2's is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
BuprenorphineZiprasidone
Critical
How does the drug interact with Buvalor 10mcg H Injection 2's:
Taking Ziprasidone with Buvalor 10mcg H Injection 2's can increase the risk of serious side effects.

How to manage the interaction:
Taking Ziprasidone with Buvalor 10mcg H Injection 2's is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
BuprenorphineBaclofen
Severe
How does the drug interact with Buvalor 10mcg H Injection 2's:
Co-administration of Buvalor 10mcg H Injection 2's with Baclofen can increase the risk of side effects.

How to manage the interaction:
Co-administration of Buvalor 10mcg H Injection 2's alongside Baclofen can result in an interaction. However, it can be taken if a doctor has advised it. If you experience shortness of breath, chest discomfort, dizziness, or palpitations consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
BuprenorphineMoxifloxacin
Severe
How does the drug interact with Buvalor 10mcg H Injection 2's:
Taking Buvalor 10mcg H Injection 2's with Moxifloxacin increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Coadministration of Buvalor 10mcg H Injection 2's alongside Moxifloxacin can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
BuprenorphineLamotrigine
Severe
How does the drug interact with Buvalor 10mcg H Injection 2's:
When Buvalor 10mcg H Injection 2's is used with lamotrigine, it may possibly lead to significant adverse effects such as respiratory difficulties, unconsciousness.

How to manage the interaction:
Concomitant administration of Buvalor 10mcg H Injection 2's alongside lamotrigine can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery until you're aware of how these medications effect you. Do not discontinue any medications without consulting a doctor.
BuprenorphineGabapentin
Severe
How does the drug interact with Buvalor 10mcg H Injection 2's:
Co-administration of Buvalor 10mcg H Injection 2's and Gabapentin may cause central nervous system depression and lead to serious side effects (respiratory distress -build-up of fluid in the air sacs of the lungs).

How to manage the interaction:
Although there is a possible interaction between Gabapentin and Buvalor 10mcg H Injection 2's, you can take these medicines together if prescribed by a doctor. However, if you experience shortness of breath, fast heart rate, fast breathing, extreme tiredness, fever, cough with phlegm, or shallow breaths, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
BuprenorphineDivalproex
Severe
How does the drug interact with Buvalor 10mcg H Injection 2's:
Co-administration of Buvalor 10mcg H Injection 2's with divalproex may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buvalor 10mcg H Injection 2's with Divalproex can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
BuprenorphineOxcarbazepine
Severe
How does the drug interact with Buvalor 10mcg H Injection 2's:
Using Buvalor 10mcg H Injection 2's together with other medications that also cause central nervous system it may lead to significant adverse effects (respiratory difficulties, and unconsciousness).

How to manage the interaction:
Concomitant administration of oxcarbazepine with Buvalor 10mcg H Injection 2's can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery. Do not discontinue any medications without consulting a doctor.
BuprenorphineEscitalopram
Severe
How does the drug interact with Buvalor 10mcg H Injection 2's:
Taking Buvalor 10mcg H Injection 2's with escitalopram increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Concomitant administration of Buvalor 10mcg H Injection 2's and escitalopram can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
BuprenorphineMorphine
Severe
How does the drug interact with Buvalor 10mcg H Injection 2's:
Coadministration of Morphine with Buvalor 10mcg H Injection 2's can increase the risk and severity of Morphine side effects

How to manage the interaction:
Taking Morphine with Buvalor 10mcg H Injection 2's can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination make sure to contact a doctor right away. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as swimming or walking.
  • Drink plenty of water while on treatment with Buvalor 10mcg H Injection to avoid dry mouth.
  • Maintain a fibre-rich diet and eat plenty of fresh fruits and vegetables to avoid constipation while receiving Buvalor 10mcg H Injection.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

Yes

Therapeutic Class

OPIOID ANTAGONISTS

Buvalor 10mcg H Injection Substitute

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Alcohol

Unsafe

Buvalor 10mcg H Injection may cause dizziness, drowsiness, blurred vision, or impaired thinking in some people. Alcohol consumption may even worsen these effects. Hence, do not consume alcohol while on treatment with this medicine.

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Pregnancy

Unsafe

Buvalor 10mcg H Injection is not recommended during pregnancy as it may cause life-threatening withdrawal symptoms in the newborn. Hence, inform your doctor before administering Buvalor 10mcg H Injection if you are pregnant or planning pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

It may be unsafe to use during breastfeeding as it passes into breastmilk and may cause sleepiness and decreased heart rate in your infant. It is not recommended for use in breastfeeding. Hence, if you are breastfeeding, inform your doctor before receiving Buvalor 10mcg H Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Unsafe

Buvalor 10mcg H Injection may cause dizziness, blurred vision or drowsiness in some people. It is an offence to drive if Buvalor 10mcg H Injection affects you. Therefore, avoid driving if you feel drowsy, dizzy or experience vision problems after administration of Buvalor 10mcg H Injection.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Buvalor 10mcg H Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Buvalor 10mcg H Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Buvalor 10mcg H Injection is not recommended for use in children below 18 years of age as the safety and effectiveness have not been established.

FAQs

Buvalor 10mcg H Injection is used to treat opioid addiction.
Buvalor 10mcg H Injection consists of Buprenorphine is an opioid partial agonist. It prevents withdrawal symptoms in patients who stop receiving opioid drugs by producing similar effects to these drugs. It also provides pain relief by acting on specific receptors in the brain that change how your body feels and responds to pain.
Yes, Buvalor 10mcg H Injection may cause withdrawal symptoms such as sweating, feeling hot and cold, runny eyes and nose, feeling or being sick, diarrhoea, stomach cramps, poor sleep, and just feeling awful. Therefore, if you experience any difficulty while receiving Buvalor 10mcg H Injection, do not stop administration suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.
Chronic use of opioids may cause reduced fertility (ability to have children) in females and males of reproductive potential. It is not known whether these effects on fertility are reversible. However, it is essential to talk to your doctor before starting treatment with Buvalor 10mcg H Injection if you think you may want to have a baby in the future.
No, you are not recommended to use Buvalor 10mcg H Injection with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis) as co-administration of these medicines with Buvalor 10mcg H Injection may cause life-threatening respiratory depression and death have occurred. However, please consult a doctor before receiving Buvalor 10mcg H Injection with other medicines.
Yes, Buvalor 10mcg H Injection may cause addiction, especially if used for a prolonged time. Therefore, Buvalor 10mcg H Injection should be given only for a short duration under strict medical supervision, particularly to patients susceptible to drug abuse. Buvalor 10mcg H Injection should be administered only as advised by a doctor as overuse, or misuse of Buvalor 10mcg H Injection can lead to overdose or death.

Country of origin

INDIA

Manufacturer/Marketer address

Ground Floor Modi Tower, 98, Nehru Place, New Delhi, Delhi 110019
Other Info - BUV0002

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