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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Blueject Injection is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy. It contains Methylene Blue, which works by converting methemoglobin to a more efficient type of haemoglobin to better carry oxygen throughout the body. Common side effects of this medication are mild to moderate pain at the site of injection, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm.

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Whats That

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Synonym :

METHYLTHIONINIUM CHLORIDE

Composition :

METHYLENE BLUE-10MG

Manufacturer/Marketer :

Vulcan Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Blueject Injection

Blueject Injection is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy. Methemoglobinemia is a condition that occurs when the blood cannot deliver oxygen where it is needed in the body. Vasodilatory shock is a medical emergency in which your body cannot get enough blood to your heart, brain, and kidneys.

Blueject Injection contains Methylene Blue. Methylene blue works by converting methemoglobin to a more efficient type of haemoglobin to better carry oxygen throughout the body.

A qualified healthcare professional will administer Blueject Injection. You may experience mild to moderate pain at the site of injection, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm. Most of these side effects of Blueject Injection do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

If you have a glucose-6-phosphate dehydrogenase (G6PD) deficiency, you should avoid using methylene blue. Many medicines, particularly antidepressants, can interact with methylene blue. So, before taking the Blueject Injection, inform your doctor about all of your medical issues, sensitivities, and drugs. Also, let your doctor know if you are pregnant, planning to become pregnant, or are breastfeeding.

Uses of Blueject Injection

Treatment of Methemoglobinemia and Vasodilatory shock

Directions for Use

A qualified healthcare professional will administer Blueject Injection. Do not self-administer.

Medicinal Benefits

Blueject Injection contains Methylene Blue, which belongs to the class of monoamine oxidase inhibitors. It is used to treat a condition called methemoglobinemia. Methylene blue converts methemoglobin into a more efficient type of haemoglobin to better carry oxygen throughout the body.

How Blueject Injection Works

Blueject Injection contains Methylene Blue. Methylene blue works by converting methemoglobin to a more efficient type of haemoglobin to better carry oxygen throughout the body.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Blueject Injection

  • Mild to moderate pain at the site of injection
  • Pain in your arms or legs
  • Blue or green urine
  • Altered sense of taste
  • Headache
  • Dizziness
  • Sweating
  • Skin discoloration
  • Nausea
  • Feeling warm

What if I have taken an overdose of Blueject Injection

As Blueject Injection is a parenteral formulation, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

It is recommended not to use it if you are allergic to methylene blue or other ingredients. Methylene blue should not be used to treat methemoglobinemia in people with glucose-6-phosphate deficiencies (G-6-PD). When methylene blue was delivered intravenously to patients who were concurrently taking other medications having serotonin reuptake inhibitor characteristics, serotonin toxicity/serotonin syndrome was reported. If drugs with serotonin reuptake inhibition capabilities are being used, they must be stopped before using methylene blue injectables to allow for a washout time of at least 4 - 5 half-lives. So, before taking the Blueject Injection, let your doctor know about all your medical conditions, sensitivities, and all medications you are using.

Drug-Drug Interactions

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Methylene blueFluvoxamine
Critical
Methylene blueAtomoxetine
Critical

Drug-Drug Interactions

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Methylene blueFluvoxamine
Critical
How does the drug interact with Blueject Injection 10 ml:
Taking Fluvoxamine with Blueject Injection 10 ml can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Fluvoxamine with Blueject Injection 10 ml is not recommended, but can be taken together if prescribed by a doctor. However, if you experience confusion, hallucination(seeing & hearing things that do not exist), seizure(fits), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor(shaking of hands & legs), incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not discontinue any medication without consulting a doctor.
Methylene blueAtomoxetine
Critical
How does the drug interact with Blueject Injection 10 ml:
Using Blueject Injection 10 ml together with atomoxetine can cause high blood pressure.

How to manage the interaction:
Taking Atomoxetine with Blueject Injection 10 ml is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not stop using any medications without talking to a doctor.
Methylene blueClomipramine
Critical
How does the drug interact with Blueject Injection 10 ml:
When Clomipramine is taken with Blueject Injection 10 ml, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clomipramine and Blueject Injection 10 ml, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.
Methylene blueAmitriptyline
Critical
How does the drug interact with Blueject Injection 10 ml:
Combining Blueject Injection 10 ml with Amitriptyline can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Blueject Injection 10 ml and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
Methylene blueEphedrine
Critical
How does the drug interact with Blueject Injection 10 ml:
When Ephedrine and Blueject Injection 10 ml are combined, there is an increase in the risk or severity of high blood pressure.

How to manage the interaction:
Taking Ephedrine and Blueject Injection 10 ml is not recommended as it can result in an interaction, it can be taken if a doctor has prescribed it. However, if you develop a sudden, severe headache, blurred vision, disorientation, seizures, chest pain, nausea, or vomiting, sudden numbness or weakness (particularly on one side of the body), difficulty speaking, fever, sweating, lightheadedness, or fainting, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
Methylene blueNortriptyline
Severe
How does the drug interact with Blueject Injection 10 ml:
Using Nortriptyline together with Blueject Injection 10 ml can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although taking Nortriptyline and Blueject Injection 10 ml together can cause an interaction, it can be taken if your doctor has suggested it. If you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not stop using any medications without a doctor's advice.
Methylene blueEscitalopram
Severe
How does the drug interact with Blueject Injection 10 ml:
Taking Escitalopram with Blueject Injection 10 ml can increase the effects of serotonin(a chemical produced in the brain) in the body.

How to manage the interaction:
Taking Escitalopram with Blueject Injection 10 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience any symptoms like confusion, hallucinations, seizures, and increased heart rate. Do not stop using any medications without first talking to your doctor.
Methylene blueSelegiline
Severe
How does the drug interact with Blueject Injection 10 ml:
When Blueject Injection 10 ml is taken with Selegiline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Blueject Injection 10 ml and Selegiline, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach cramp, nausea, vomiting, and diarrhea, call a doctor. Do not stop using any medications without a doctor's advice.
Methylene blueSumatriptan
Severe
How does the drug interact with Blueject Injection 10 ml:
Using Blueject Injection 10 ml together with Sumatriptan might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although there is a possible interaction between Sumatriptan and Blueject Injection 10 ml, you can take these medicines together if prescribed by your doctor. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
Methylene blueEntacapone
Severe
How does the drug interact with Blueject Injection 10 ml:
Combining Entacapone with Blueject Injection 10 ml can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Entacapone with Blueject Injection 10 ml together can result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling confused or hallucinating, having a seizure, a fast heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty coordinating movements, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Adhering to a regular meal pattern, minimizing intake of insoluble fibers, alcohol, caffeine, spicy foods, and fat, as well as engaging in regular physical activity and being hydrated, are all standard suggestions.
  • Keep a diet or food diary.
  • Make time to eat. If possible, sit down, relax, and enjoy your meal with others. Avoid eating while on the go!
  • Eat three regular meals a day, at nearly the same times and in roughly the same amounts.
  • Maintain an active lifestyle and get enough exercise. This will make you feel better.
  • Avoid high-fat meals and limit your intake of poorly absorbed carbs.
  • Maintain a balanced lifestyle and try to reduce stress as much as possible. Allow yourself time to relax and do things you enjoy. 
  • Avoid drinking alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Blueject Injection Substitute

Substitutes safety advice
  • Methblu-10 Injection 10 ml

    29.70per tablet
  • Methylene Blue Injection

    270.00per tablet
  • Blue Beam 10 mg Injection 10 ml

    19.62per tablet
  • Sam MB 10mg Injection

    225.00per tablet
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Alcohol

Caution

It is not known whether Blueject Injection interacts with alcohol. However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Caution

Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Blueject Injection.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking Blueject Injection; your doctor may suggest stopping breastfeeding for a certain period.

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Driving

Safe if prescribed

Blueject Injection usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Limited information was available about using Blueject Injection in patients with liver disease. Inform your doctor before receiving Blueject Injection if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Use with caution in patients with kidney failure, as methylene blue is primarily excreted through the kidneys. Inform your doctor before receiving Blueject Injection if you have a history of kidney diseases. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

Please consult your doctor. Your doctor will prescribe this medicine based on your child's condition.

FAQs

Blueject Injection is used to treat a condition called methemoglobinemia. Besides this, it can be used to treat vasodilatory shock unresponsive to conventional therapy.
Blueject Injection contains Methylene Blue. Methylene blue converts methemoglobin into a more efficient type of haemoglobin to better carry oxygen throughout the body. Thus, it efficiently treats a condition called methemoglobinemia.
Injection site reactions, pain in your arms or legs, blue or green urine, altered sense of taste, headache, dizziness, sweating, skin discolouration, nausea, and feeling warm are the common side effects of Blueject Injection.
If you are currently taking anti-depressant medications such as escitalopram, notify your doctor before receiving methylene blue. Combining these medications can increase the risk of an uncommon but deadly disease known as serotonin syndrome, which can cause symptoms such as confusion, hallucination, seizure, dramatic fluctuations in blood pressure, rapid heart rate, and fever.

Country of origin

India

Manufacturer/Marketer address

14/1 Ram Mohan Dutt Rd Kolkata Wb 700020 In
Other Info - BLU0135

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