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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Avol-300 CR Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). It contains Sodium valproate, which decreases the excessive and abnormal nerve activity in the brain. Thereby, helps in controlling seizures. It helps block the nerve transmission across the brain and provides a calming effect. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Elikem Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Avol-300 CR Tablet

Avol-300 CR Tablet is used to treat epilepsy/seizures/fits. Additionally, Avol-300 CR Tablet is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state. 
­ 
Avol-300 CR Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Avol-300 CR Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
You can take Avol-300 CR Tablet with or without food. You are advised to take Avol-300 CR Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as stomach pain, nausea, vomiting, dry mouth, tremors, tiredness, sleepiness, headache, weight gain, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Please do not stop taking Avol-300 CR Tablet without consulting your doctor to avoid worsening of seizures. Contact your doctor if your child gets her first period whilst on treatment with Avol-300 CR Tablet . Do not take Avol-300 CR Tablet if you are pregnant, as it could cause serious congenital disabilities. If you are of childbearing age, use effective contraception while taking Avol-300 CR Tablet . Consult your doctor before taking Avol-300 CR Tablet if you are breastfeeding. Do not drive or operate machinery as Avol-300 CR Tablet may cause drowsiness and dizziness. Avoid consuming alcohol along with Avol-300 CR Tablet as it could lead to increased dizziness and sleepiness.

Uses of Avol-300 CR Tablet

Treatment of Epilepsy, Bipolar Disorder, Migraine.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not chew or break the tablet/capsule. Oral solution: Take the prescribed dose/quantity by mouth using the measuring cup/dosing syringe; shake the pack well before each use.

Medicinal Benefits

Avol-300 CR Tablet belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Additionally, Avol-300 CR Tablet is also used to treat bipolar disorder and prevent migraine headaches. Avol-300 CR Tablet decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Avol-300 CR Tablet is used to treat both localized (seizures which affect only a part of the brain) and generalized seizures (seizures which affect the entire brain).

How Avol-300 CR Tablet Works

Avol-300 CR Tablet contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Avol-300 CR Tablet increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Avol-300 CR Tablet

  • Stomach pain
  • Nausea
  • Vomiting
  • Dry mouth
  • Tremors
  • Tiredness
  • Sleepiness
  • Headache
  • Weight gain
  • Hair loss

What if I have taken an overdose of Avol-300 CR Tablet

Do not take more than the prescribed dose of Avol-300 CR Tablet as it may cause overdose. The symptoms of overdose include headache, dizziness, confusion, memory loss, tiredness, feeling sick or being sick, blurred vision due to pupil of the eye becoming smaller, poor reflexes, weak or floppy muscles, fits, loss of consciousness, behavioural changes and breathing difficulties such as fast breathing, shortness of breath or chest pain. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Avol-300 CR Tablet if you are allergic to any of its contents; if you have liver problems, porphyria, urine-related problems (like urea cycle disorder), diabetes, immune system disorder or kidney problems. Consult your doctor immediately if you experience suicidal tendencies while taking Avol-300 CR Tablet . Contact your doctor if your child gets her first period during the treatment with Avol-300 CR Tablet . Do not take Avol-300 CR Tablet if you are pregnant unless prescribed by the doctor as it is pregnancy category C medicine and can cause serious congenital disabilities. Consult your doctor before taking Avol-300 CR Tablet if you are breastfeeding. Avol-300 CR Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Avol-300 CR Tablet as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateErtapenem
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Avol-300 CR Tablet:
Combining Sodium phenylbutyrate and Avol-300 CR Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Avol-300 CR Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Avol-300 CR Tablet:
The combined use of Ertapenem and Avol-300 CR Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Avol-300 CR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Avol-300 CR Tablet:
Co-administration of Meropenam and Avol-300 CR Tablet together can reduce the effect of Avol-300 CR Tablet.

How to manage the interaction:
Co-administration of Meropenam and Avol-300 CR Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Avol-300 CR Tablet:
Co-administration of Lithium with Avol-300 CR Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Avol-300 CR Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Avol-300 CR Tablet:
Using buprenorphine together with Avol-300 CR Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Avol-300 CR Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Avol-300 CR Tablet:
Co-administration of Avol-300 CR Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Avol-300 CR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Avol-300 CR Tablet:
Co-administration of Vorinostat with Avol-300 CR Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Avol-300 CR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Avol-300 CR Tablet:
Co-administration of Teriflunomide and Avol-300 CR Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Avol-300 CR Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Avol-300 CR Tablet:
Co-administration of Ketamine and Avol-300 CR Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Avol-300 CR Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Avol-300 CR Tablet:
Co-administration of Leflunomide and Avol-300 CR Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Avol-300 CR Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.

  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.

  • Exercising regularly helps in maintaining weight and improving overall health. 

  • Rest well; get plenty of sleep.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.

  • Have a seizure response plan that helps those around you know what to do.

  • Prepare your living area; small changes may help in reducing the risk of physical injury during a seizure.

  • Understand what triggers seizures and try reducing or avoiding them.

  • Please pay attention to overall health as it can help in reducing seizure activity.

  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Avol-300 CR Tablet Substitute

Substitutes safety advice
  • Encorate 300 Tablet 10's

    by Others

    4.46per tablet
  • Valtec CR 300 Tablet 10's

    by Others

    6.12per tablet
  • Valprid-CR 300 mg Tablet 15's

    by Others

    6.12per tablet
  • Valporate Chrono 300 Tablet 10's

    by Others

    4.86per tablet
  • Valgress-CR-300 Tablet 10's

    by Others

    6.03per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Avol-300 CR Tablet as it may cause increased dizziness and sleepiness.

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Pregnancy

Unsafe

Avol-300 CR Tablet belongs to pregnancy category D. Avoid taking Avol-300 CR Tablet if you are pregnant as it could lead to serious birth defects.

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Breast Feeding

Caution

Avol-300 CR Tablet may pass into breastmilk. Consult your doctor before taking Avol-300 CR Tablet if you are breastfeeding.

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Driving

Unsafe

Avol-300 CR Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Avol-300 CR Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Avol-300 CR Tablet can be given to children if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight.

FAQs

Avol-300 CR Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder and prevent symptoms of migraine (like a headache).

Avol-300 CR Tablet decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.

Avol-300 CR Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.

Avol-300 CR Tablet limits the transmission of nerve pain, thereby prevents migraine headache. Migraine is a neurological condition which is characterized by intense headaches.

Do not discontinue Avol-300 CR Tablet without consulting your doctor. To treat your condition effectually, continue taking Avol-300 CR Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Avol-300 CR Tablet ; your doctor will reduce the dose gradually to avoid worsening of seizures.

Country of origin

India
Other Info - AVO0059

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