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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 10:52 AM IST

Aprotin 500000IU Injection is used to reduce the risk of bleeding during and after surgery. It contains aprotinin that prevents bleeding by inhibiting the activation of coagulants. In some cases, Aprotin 500000IU Injection may cause chest pain, stomach upset, fast heartbeat and injection site reactions. It is not recommended for children below 18 years as the safety and effectiveness have not been established. Keep your doctor informed about your health condition and medications to rule out any unpleasant side effects/interactions.

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Prescription drug

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Manufacturer/Marketer

Vhb Life Sciences Inc

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Aprotin 500000IU Injection

Aprotin 500000IU Injection belongs to the group of medicines called anti-fibrinolytic agents used to reduce bleeding during and after heart surgery. It is also used to lower the need for blood transfusion during and after heart surgery.

Aprotin 500000IU Injection contains aprotinin that prevents bleeding by inhibiting the activation of coagulants.

Aprotin 500000IU Injection will be administered by a healthcare professional; do not self-administer. In some cases, Aprotin 500000IU Injection may cause chest pain, stomach upset, fast heartbeat and injection site reactions. You are advised to talk to the doctor if you experience any side effects.

Consult the doctor if you are pregnant or breastfeeding. Aprotin 500000IU Injection is not recommended for children below 18 years as the safety and effectiveness have not been established. Keep your doctor informed about your health condition and medications to rule out any unpleasant side effects/interactions.

Uses of Aprotin 500000IU Injection

Used to reduce the risk of bleeding during and after surgery

Medicinal Benefits

Aprotin 500000IU Injection contains aprotinin that belongs to the group of medicines called anti-fibrinolytic agents used to reduce bleeding during and after heart surgery. It also lowers the need for blood transfusion during and after heart surgery. Aprotin 500000IU Injection inhibits the activation of coagulants. Thereby, Aprotin 500000IU Injection prevents bleeding.

Directions for Use

Aprotin 500000IU Injection will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Aprotin 500000IU Injection

  • Chest pain
  • Fast heartbeat
  • Stomach upset
  • Pain and irritation at the site of administration

Drug Warnings

Do not use Aprotin 500000IU Injection if you are allergic to any of its components or if a positive aprotinin-specific IgG antibody test is available, indicating an increased risk of an allergic reaction to aprotinin. Inform the doctor if you have kidney problems or have/suspect you have received aprotinin or aprotinin-containing fibrin sealants in the last 12 months. Consult the doctor if you are pregnant or breastfeeding. Let the doctor know if you have any health condition or if you are taking any medications, including herbal products or vitamin/mineral supplements.

Drug Interactions

Drug-Drug Interactions: Inform the doctor if you take medicines used to dissolve blood clots (streptokinase, urokinase, alteplase) or antibiotics (aminoglycosides).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform the doctor if you have kidney problems.

Drug-Drug Interactions Checker List

  • STREPTOKINASE
  • UROKINASE
  • ALTEPLASE

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Cut down on saturated fats, added sugars and salts.
  • Manage stress with meditation and yoga.
  • Avoid junk food and fast food.
  • Follow a low-fat, low-cholesterol, high-fiber diet.

Special Advise

Aprotin 500000IU Injection may affect certain lab tests. If you are undergoing any lab tests, inform the doctor that you are on treatment with Aprotin 500000IU Injection.

Disease/Condition Glossary

Perioperative blood management: It is a process to stop or prevent bleeding during surgery and avoid or minimise blood transfusion.

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Alcohol

Consult your doctor

It is not known if Aprotin 500000IU Injection interacts with alcohol. Please consult your doctor.

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Pregnancy

Caution

If you are pregnant, inform your doctor before receiving Aprotin 500000IU Injection. The doctor will prescribe the medicine only if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Aprotin 500000IU Injection. The doctor will prescribe the medicine only if the benefits outweigh the risks.

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Driving

Not applicable

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Aprotin 500000IU Injection.

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before receiving Aprotin 500000IU Injection. It should be used only in patients with kidney problems if the doctor/surgeon thinks the benefits outweigh the risks.

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Children

Unsafe

Aprotin 500000IU Injection is not recommended for children below 18 years as the safety and efficacy have not been established.

Country of origin

India
Other Info - AP95418

Author Details

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FAQs

Aprotin 500000IU Injection is used to reduce the risk of bleeding during and after surgery.
Aprotin 500000IU Injection works by inhibiting the activation of coagulants. Thereby, Aprotin 500000IU Injection prevents bleeding.
Aprotin 500000IU Injection is prescribed when the doctor has decided that you will benefit from the treatment because you are at an increased risk of major blood loss as you will undergo a heart bypass operation using the heart-lung machine (circulation outside the body). Your doctor will prescribe Aprotin 500000IU Injection only after careful consideration of the benefits and risks.
Aprotin 500000IU Injection may raise the risk of kidney problems, and there may be a need for dialysis after surgery. This risk might be higher in patients with existing kidney problems or in people taking medicines that harm the kidneys, such as gentamicin. Therefore, inform the doctor if you have kidney problems.

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