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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Aprifast 125/80 mg Capsule Kit is used to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. It contains Aprepitant, which blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

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Manufacturer/Marketer :

Axiommax Oncology Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Aprifast 125/80 mg Capsule Kit

Aprifast 125/80 mg Capsule Kit belongs to a class of drugs called anti-emetics. It is used to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Aprifast 125/80 mg Capsule Kit contains Aprepitant. Aprepitant blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

Take Aprifast 125/80 mg Capsule Kit as prescribed. You are recommended to take Aprifast 125/80 mg Capsule Kit for as long as your doctor has advised it. In some cases, Aprifast 125/80 mg Capsule Kit may cause common side effects such as headache, constipation, loss of appetite, tiredness, indigestion, and hiccups. Most of these side effects do not require medical attention and gradually resolve over time. However, inform your doctor if the side effects persist or worsen.

Please tell your doctor if you are allergic to Aprifast 125/80 mg Capsule Kit or any other medicines. Aprifast 125/80 mg Capsule Kit is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking Aprifast 125/80 mg Capsule Kit . Avoid driving or operating machinery if you feel dizzy or sleepy after taking Aprifast 125/80 mg Capsule Kit . If you are taking other prescription or non-prescription medicines, inform your doctor before taking Aprifast 125/80 mg Capsule Kit .

Uses of Aprifast 125/80 mg Capsule Kit

Treatment of Chemotherapy-induced nausea and vomiting

Directions for Use

Take Aprifast 125/80 mg Capsule Kit with or without food as advised by your doctor. Always take Aprifast 125/80 mg Capsule Kit together with other medicines. Swallow it as a whole with some liquid; do not crush, break or chew it.

Medicinal Benefits

Aprifast 125/80 mg Capsule Kit contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.

How Aprifast 125/80 mg Capsule Kit Works

Aprifast 125/80 mg Capsule Kit contains Aprepitant, which blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Aprifast 125/80 mg Capsule Kit

  • Headache
  • Constipation
  • Loss of appetite
  • Tiredness
  • Indigestion
  • Hiccups

What if I have taken an overdose of Aprifast 125/80 mg Capsule Kit

Since Aprifast 125/80 mg Capsule Kit is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Please tell your doctor if you are allergic to Aprifast 125/80 mg Capsule Kit or any other medicines. Aprifast 125/80 mg Capsule Kit is not recommended for children below 12 years of age. If you are pregnant or breastfeeding, please inform your doctor before taking Aprifast 125/80 mg Capsule Kit . Avoid driving or operating machinery if you feel dizzy or sleepy after taking Aprifast 125/80 mg Capsule Kit . If you are taking any other prescription or non-prescription medicines, inform your doctor before taking Aprifast 125/80 mg Capsule Kit .

Drug-Drug Interactions

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AprepitantPimozide
Critical
AprepitantFlibanserin
Critical

Drug-Drug Interactions

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AprepitantPimozide
Critical
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Using pimozide together with Aprifast 125/80 mg Capsule Kit may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Aprifast 125/80 mg Capsule Kit and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Using flibanserin together with Aprifast 125/80 mg Capsule Kit can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Aprifast 125/80 mg Capsule Kit together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Co-administration with Aprifast 125/80 mg Capsule Kit and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Aprifast 125/80 mg Capsule Kit and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
AprepitantTerfenadine
Critical
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Co-administration with Aprifast 125/80 mg Capsule Kit and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Aprifast 125/80 mg Capsule Kit and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Lomitapide blood levels can be significantly increased by combining it with Aprifast 125/80 mg Capsule Kit .

How to manage the interaction:
Although using Lomitapide and Aprifast 125/80 mg Capsule Kit together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantCisapride
Critical
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Co-administration with Aprifast 125/80 mg Capsule Kit and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Aprifast 125/80 mg Capsule Kit and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Aprifast 125/80 mg Capsule Kit combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Aprifast 125/80 mg Capsule Kit and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantAvanafil
Severe
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Aprifast 125/80 mg Capsule Kit may considerably raise Avanafil levels in the blood. This increases the severity of side effects.

How to manage the interaction:
Although the co-administration of Aprifast 125/80 mg Capsule Kit and Avanafil may result in an interaction, they can be taken if prescribed by a doctor. Contact a doctor if you have any of the following symptoms: low blood pressure, dizziness, lightheadedness, fainting, visual problems, ringing sound in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, or priapism (prolonged and painful erection unrelated to sexual activity). Do not discontinue any medications without doctor's consultation.
AprepitantBrexpiprazole
Severe
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Coadministration of Aprifast 125/80 mg Capsule Kit may raise Brexpiprazole levels in the blood when taken together.

How to manage the interaction:
Even though Aprifast 125/80 mg Capsule Kit and Brexpiprazole interact, they can be used if prescribed by a doctor. If you have anxiety, irritability, confusion, fits, muscle cramps, lip smacking, chewing, puckering, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, restlessness, foot tapping, low blood pressure such as dizziness, lightheadedness, fainting, and/or an elevated pulse or heart rate call a doctor. Do not discontinue any medications without consulting a doctor.
AprepitantEplerenone
Severe
How does the drug interact with Aprifast 125/80 mg Capsule Kit :
Eplerenone levels in the blood may be significantly elevated by Aprifast 125/80 mg Capsule Kit .This could make adverse effects more severe.

How to manage the interaction:
Although coadministration of Aprifast 125/80 mg Capsule Kit and Eplerenone can lead to an interaction, they can be taken if prescribed by a doctor Consult a doctor if you have any kidney-related symptoms (swollen ankles, tiredness, shortness of breath, difficulty in sleeping, itchy skin), nausea, vomiting, weakness, confusion, tingling in the hands and feet, heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Without consulting a doctor, never stop taking medicines.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated.
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting.
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Aprifast 125/80 mg Capsule Kit Substitute

Substitutes safety advice
  • Aprecap 125/80 Capsule Kit 3's

    394.20per tablet
  • Empov 125/80Mg Capsule

    390.00per tablet
  • Apriset 125/80 Capsule Kit 3's

    459.00per tablet
  • Aprelief Kit 125/80Mg Capsule

    1082.40per tablet
  • Apretero 125/80 Capsule 1's

    1287.00per tablet
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Alcohol

Caution

The interaction of alcohol with Aprifast 125/80 mg Capsule Kit is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking Aprifast 125/80 mg Capsule Kit . Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before taking Aprifast 125/80 mg Capsule Kit .

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Driving

Caution

Aprifast 125/80 mg Capsule Kit may cause dizziness or drowsiness in some people. Hence, do not drive or operate machinery if you feel dizzy or drowsy after taking Aprifast 125/80 mg Capsule Kit .

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Liver

Consult your doctor

If you have liver disease, inform your doctor before taking Aprifast 125/80 mg Capsule Kit . Your doctor may monitor your liver condition.

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Kidney

Consult your doctor

If you have kidney problems, inform your doctor before taking Aprifast 125/80 mg Capsule Kit .

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Children

Unsafe

Aprifast 125/80 mg Capsule Kit is not recommended for children below 12 years of age.

FAQs

Aprifast 125/80 mg Capsule Kit is used to treat Chemotherapy-induced nausea and vomiting.
Aprifast 125/80 mg Capsule Kit contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.
You are not recommended to take erythromycin with Aprifast 125/80 mg Capsule Kit as it may increase the blood levels and effects of Aprifast 125/80 mg Capsule Kit . Contact your doctor if your condition changes or you experience side effects such as diarrhoea, constipation, nausea, or loss of appetite. However, please consult your doctor before taking other medicines with Aprifast 125/80 mg Capsule Kit .
You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain Intrauterine devices (IUDs) as they may not work properly when taken together with Aprifast 125/80 mg Capsule Kit . Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Aprifast 125/80 mg Capsule Kit and for up to 2 months after using Aprifast 125/80 mg Capsule Kit .

Country of origin

India

Manufacturer/Marketer address

A/303, Atrium -1, Andheri - Kurla Road, Mumbai 400 059 India
Other Info - APR0133

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