Aprezo 20 Tablet is used to treat Plaque psoriasis (scaly, itchy, and red patches on the skin), psoriasis arthritis (inflammation in the joints in people with psoriasis), and oral ulcers. Psoriasis is a chronic, painful, nontransmissible, deactivating and damaging disease. It can happen at any age and is most common in the age group 50 to 69. Psoriatic arthritis is a type of arthritis that some people with psoriasis experience.

Aprezo 20 Tablet contains Apremilast, a phosphodiesterase 4 (PDE4) inhibitor. Aprezo 20 Tablet works by blocking the action of some chemical messengers that are responsible for inflammation related to psoriatic arthritis (inflammation in the joints in people with psoriasis) and psoriasis (scaly, itchy, and red patches on the skin) and, thus, lower the signs and symptoms of these conditions.

Take Aprezo 20 Tablet as prescribed by your doctor. You are advised to take Aprezo 20 Tablet for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience diarrhoea, vomiting, nausea, weight loss, and back pain. Most of these side effects of Aprezo 20 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Aprezo 20 Tablet should not be taken in conditions like depression as it is getting worse with thoughts of suicide. Before starting Aprezo 20 Tablet, please inform your doctor if you have any allergy to Aprezo 20 Tablet and its parts. Aprezo 20 Tablet not recommended for use in children and adolescents aged below 17 years. If you are pregnant or breastfeeding, ask your doctor for advice before taking this Aprezo 20 Tablet. Aprezo 20 Tablet does not affect the ability to drive and use machines.

Aprezo 20 Tablet is used in treating psoriatic arthritis; it decreases pain and swelling and may help improve flexibility in the affected joints. It is also used to treat moderate to severe plaque psoriasis (skin disease causes red, scaly patches to form on some areas of the body) in people who may benefit from medications). It is used to treat ulcers in the mouth in persons with Behcet's syndrome (a disease that results from blood vessel swelling in the body). Aprezo 20 Tablet works by blocking the action of some chemical messengers responsible for inflammation related to psoriatic arthritis and psoriasis, thus lowering the signs and symptoms of these conditions.

• Diarrhea
• Vomiting
• Nausea
• Weight loss
• Back pain

Inform your doctor before using Aprezo 20 Tablet, if you have previously had an allergic reaction (hypersensitivity). Before starting Aprezo 20 Tablet, please inform your doctor if you have depression and suicidal thoughts. Inform your doctor before taking Aprezo 20 Tablet if you have severe kidney problems. Inform your doctor while taking Aprezo 20 Tablet if you lose weight without meaning to. Aprezo 20 Tablet should not be taken in conditions like severe diarrhoea, nausea, and vomiting. Aprezo 20 Tablet not recommended for use in children and adolescents aged below 17 years. If you are pregnant or breastfeeding, ask your doctor for advice before taking this Aprezo 20 Tablet. Patients with rare hereditary galactose intolerance problems, total lactase deficiency or glucose-galactose malabsorption should not take Aprezo 20 Tablet.

Drug-Drug Interactions: Aprezo 20 Tablet may interact with medicines used for tuberculosis- TB (rifampicin), and medicines used in fit/epilepsy (phenytoin, phenobarbital, carbamazepine).

Drug-Food Interactions: No food interactions were found.

Drug-Disease Interactions: Aprezo 20 Tablet should not be given to patients with depression, kidney disease, and weight loss.

• RIFAMPICIN
• PHENYTOIN
• CARBAMAZEPINE
• PHENOBARBITAL

• Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20minutes regularly.
• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
• Acupuncture, massage and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
• Avoid smoking and alcohol consumption.

• Aprezo 20 Tablet is a well-tolerated medicine. Mild stomach upset may arise early during the treatment.
• Monitor your weight repeatedly as Aprezo 20 Tablet may lead to weight loss.
• Inform your doctor immediately if you experience new or worsened depression, suicidal thoughts, unexplained weight loss, or other mood changes.

Plaque Psoriasis: It is an inflammatory disease of the skin, leading to red, scaly, thick, itchy, painful patches on your skin and can also affect your nails and scalp. It can happen at any age and is most common in 50 to 69. Internal and external activities, including sunburn, mild trauma, systemic drugs, infections, and stress, can also cause psoriasis.

Psoriatic arthritis: Psoriatic arthritis is an inflammatory disorder of the joints, which affects a few people who have skin from psoriasis.

Behçet’s disease: It is an uncommon type of inflammatory illness that affects many parts of the body. The most common difficulty is mouth ulcers. It is a disease that results in blood vessel swelling in the body.