Apivas-5 Tablet is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, Apivas-5 Tablet is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). Deep vein thrombosis is a condition in which blood clots form in deep veins, usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs. Atrial fibrillation is a condition that causes irregular, often fast heartbeat.

Apivas-5 Tablet contains Apixaban, which works by inhibiting the action of blood clotting factor (X a), which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein) and helps in preventing blood clot formation.

Take Apivas-5 Tablet as prescribed. Your doctor will advise you how often you take Apivas-5 Tablet based on your medical condition. Some people may experience nausea, anaemia (lack of blood), and unusual bleeding, including swelling and bruising. Most of these side effects of Apivas-5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Apivas-5 Tablet or any other medicines, please tell your doctor. If you are pregnant or a nursing mother, you are advised to consult a doctor before using Apivas-5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure, or bleeding problems, inform your doctor before taking Apivas-5 Tablet . Your doctor may suggest a blood test called the 'international normalized ratio' (INR) to check how quickly your blood is clotting. This test result will help your doctor to decide exactly when you should start taking Apivas-5 Tablet .

Apivas-5 Tablet is primarily used to prevent and treat blood clots in the body by inhibiting the action of clotting factor Xa, which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helps in preventing blood clot formation.

• Nausea
• Anaemia (lack of blood)
• Bleeding, including swelling and bruising

Apivas-5 Tablet should not be used in children. Blood tests are advised before and while taking Apivas-5 Tablet to monitor kidney and liver functioning. If you are pregnant or breastfeeding, please inform your doctor before taking Apivas-5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure or bleeding problems, antiphospholipid syndrome (an immune system disorder that causes an increased risk of blood clots), inform your doctor before taking Apivas-5 Tablet .

Drug-Drug Interaction: Apivas-5 Tablet may have interaction with pain killers (acetylsalicylic acid, naproxen, ibuprofen), heart-related medicines (diltiazem), antidepressants (nortriptyline, amitriptyline), antifungal drugs (ketoconazole), antibiotics (rifampicin), epilepsy or fits related medicines (phenytoin), anti-HIV/AIDS drugs (ritonavir) and blood thinners (warfarin, enoxaparin, heparin, clopidogrel, rivaroxaban, dabigatran).

Drug-Food Interaction: Apivas-5 Tablet may interact with St John’s Wort (herbal supplement for depression). Limit intake of alcohol and do not exceed 14 units per week as it may increase the risk of bleeding.

Drug-Disease Interaction: If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure or bleeding problems, antiphospholipid syndrome (an immune disorder of bleeding),  inform your doctor before taking Apivas-5 Tablet .

• ASPIRIN
• CLOPIDOGREL
• DILTIAZEM
• HEPARIN
• IBUPROFEN
• NAPROXEN
• RIVAROXABAN

• Avoid vitamin K rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, Brussels sprouts as they may decrease the effectiveness of Apivas-5 Tablet .

• Do regular exercise as it helps to dissolve blood clots especially in obese people.

• Do not consume more than 14 units of alcohol per week as excess alcohol intake may increase the risk of bleeding and quit smoking.

Complete blood count (CBC), INR test, prothrombin tests are advised before and while taking Apivas-5 Tablet .

Deep vein thrombosis (blood clots in the legs) is a medical condition in which blood clots form in deep veins, usually in the legs. The symptoms include leg pain or swelling.

Pulmonary embolism (blood clots in the lungs) is a condition which occurs as the blood clots break and travel to the lungs from deep veins in the legs or other parts of the body. The symptoms of pulmonary embolism include cough, chest pain and shortness of breath. Quick medication is advised to reduce the risk of serious conditions due to blood clots.

Atrial fibrillation is a condition that causes irregular, often fast heartbeat. In atrial fibrillation condition, blood clots are formed as blood is pooled in the upper chambers of the heart.