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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Apigy-5 Tablet is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, it is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). It contains Apixaban, which works by inhibiting the action of blood clotting factor and prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein). Thus, it helps in preventing blood clot formation. Some people may experience side effects such as nausea, anaemia (lack of blood), and unusual bleeding, including swelling and bruising. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

APIXABAN-5MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Apigy-5 Tablet

Apigy-5 Tablet is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, Apigy-5 Tablet is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). Deep vein thrombosis is a condition in which blood clots form in deep veins, usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs. Atrial fibrillation is a condition that causes irregular, often fast heartbeat.

Apigy-5 Tablet contains Apixaban, which works by inhibiting the action of blood clotting factor (X a), which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein) and helps in preventing blood clot formation.

Take Apigy-5 Tablet as prescribed. Your doctor will advise you how often you take Apigy-5 Tablet based on your medical condition. Some people may experience nausea, anaemia (lack of blood), and unusual bleeding, including swelling and bruising. Most of these side effects of Apigy-5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Apigy-5 Tablet or any other medicines, please tell your doctor. If you are pregnant or a nursing mother, you are advised to consult a doctor before using Apigy-5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure, or bleeding problems, inform your doctor before taking Apigy-5 Tablet . Your doctor may suggest a blood test called the 'international normalized ratio' (INR) to check how quickly your blood is clotting. This test result will help your doctor to decide exactly when you should start taking Apigy-5 Tablet .

Uses of Apigy-5 Tablet

Treatment of Prevention of blood clot.

Directions for Use

Take Apigy-5 Tablet with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not chew or break it. If you have difficulty swallowing the whole tablet, crush it and mix it with water, 5 % dextrose in water, apple puree, or juice.

Medicinal Benefits

Apigy-5 Tablet is primarily used to prevent and treat blood clots in the body by inhibiting the action of clotting factor Xa, which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helps in preventing blood clot formation.

How Apigy-5 Tablet Works

Apigy-5 Tablet contains Apixaban, which works by inhibiting the action of blood clotting factor (X a), which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein) and helps in preventing blood clot formation.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Apigy-5 Tablet

  • Nausea
  • Anaemia (lack of blood)
  • Bleeding, including swelling and bruising

What if I have taken an overdose of Apigy-5 Tablet

Do not take more than the prescribed dose of Apigy-5 Tablet as it may cause overdose. The symptoms of overdose include unusual bleeding or bruising, red/black/tarry stools, red/brown/pink urine and coughing up or vomiting blood or material that looks like coffee grounds. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Apigy-5 Tablet should not be used in children. Blood tests are advised before and while taking Apigy-5 Tablet to monitor kidney and liver functioning. If you are pregnant or breastfeeding, please inform your doctor before taking Apigy-5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure or bleeding problems, antiphospholipid syndrome (an immune system disorder that causes an increased risk of blood clots), inform your doctor before taking Apigy-5 Tablet .

Drug-Drug Interactions

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ApixabanDefibrotide
Critical
ApixabanMifepristone
Critical

Drug-Drug Interactions

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ApixabanDefibrotide
Critical
How does the drug interact with Apigy-5 Tablet 10's:
Coadministration of Defibrotide and Apigy-5 Tablet 10's co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Defibrotide and Apigy-5 Tablet 10's may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanMifepristone
Critical
How does the drug interact with Apigy-5 Tablet 10's:
Mifepristone and Apigy-5 Tablet 10's co-administration have been associated with more severe vaginal bleeding in women.

How to manage the interaction:
Taking Apigy-5 Tablet 10's with Mifepristone together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
ApixabanMefenamic acid
Severe
How does the drug interact with Apigy-5 Tablet 10's:
Mefenamic acid and Apigy-5 Tablet 10's co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Mefenamic acid and Apigy-5 Tablet 10's may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without first consulting your doctor, never stop taking any medications.
ApixabanEpoprostenol
Severe
How does the drug interact with Apigy-5 Tablet 10's:
Coadministration of Epoprostenol and Apigy-5 Tablet 10's co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Epoprostenol and Apigy-5 Tablet 10's may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanUrokinase
Severe
How does the drug interact with Apigy-5 Tablet 10's:
Coadministration of Urokinase and Apigy-5 Tablet 10's co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Urokinase and Apigy-5 Tablet 10's may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanRifapentine
Severe
How does the drug interact with Apigy-5 Tablet 10's:
Apigy-5 Tablet 10's's blood levels can be considerably lowered by taking it along with Rifapentine.

How to manage the interaction:
Although Co-administration of Rifapentine and Apigy-5 Tablet 10's can lead to an interaction, they can be taken in case a doctor advises it to. Rifapentine makes Apigy-5 Tablet 10's less effective in treating and preventing blood clots. Never discontinue taking a medication without consulting a doctor.
ApixabanNaproxen
Severe
How does the drug interact with Apigy-5 Tablet 10's:
Coadministration of Naproxen and Apigy-5 Tablet 10's co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Naproxen and Apigy-5 Tablet 10's may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanHeparin
Severe
How does the drug interact with Apigy-5 Tablet 10's:
Coadministration of Heparin and Apigy-5 Tablet 10's co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Heparin and Apigy-5 Tablet 10's may cause an interaction, it is still possible to take it if a doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanDiclofenac
Severe
How does the drug interact with Apigy-5 Tablet 10's:
Co-administration of Diclofenac and Apigy-5 Tablet 10's may raise the risk of stomach bleeding.

How to manage the interaction:
Although there is a interaction between diclofenac and Apigy-5 Tablet 10's, but it can be taken if your doctor has advised it. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Do not discontinue any medication without consulting a doctor.
ApixabanTelaprevir
Severe
How does the drug interact with Apigy-5 Tablet 10's:
Telaprevir may significantly increase the blood levels of Apigy-5 Tablet 10's. This can increase the risk of serious bleeding complications.

How to manage the interaction:
Even though combining Telaprevir and Apigy-5 Tablet 10's may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid vitamin K rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, Brussels sprouts as they may decrease the effectiveness of Apigy-5 Tablet .

  • Do regular exercise as it helps to dissolve blood clots especially in obese people.

  • Do not consume more than 14 units of alcohol per week as excess alcohol intake may increase the risk of bleeding and quit smoking.

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Apigy-5 Tablet Substitute

Substitutes safety advice
  • Eliquis 5 mg Tablet 10's

    48.87per tablet
  • Apigat 5 Tablet 30's

    by AYUR

    25.65per tablet
  • Apixator 5 mg Tablet 10's

    16.25per tablet
  • Elixaban 5 Tablet 10's

    14.67per tablet
  • Apixapil 5 Tablet 10's

    10.67per tablet
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Alcohol

Caution

You are recommended not to consume more than 14 units per week as exceeding this may increase the risk of bleeding.

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Pregnancy

Caution

Apigy-5 Tablet is a Category B pregnancy drug and is given to pregnant women only if doctor thinks benefits outweigh risks.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Apigy-5 Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Safe if prescribed

Apigy-5 Tablet usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Take Apigy-5 Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Apigy-5 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Apigy-5 Tablet is not recommended for children below 18 years of age.

FAQs

Apigy-5 Tablet is used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, it is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). Apigy-5 Tablet works by inhibiting the action of blood clotting factor (X a), which is an important element of blood clotting.
No, you are not recommended to take ibuprofen with Apigy-5 Tablet as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, red or black tarry stools, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.
No, you are usually not advised to have a tattoo or body piercing while taking Apigy-5 Tablet as it may increase the risk of bleeding and infection. If you still wish to proceed further, contact your doctor so that the dose may be adjusted or any antibiotics may be prescribed and let the piercer or tattooist know in advance that you are on treatment with a blood thinner.
Yes, you are advised to stop taking Apigy-5 Tablet a few days before surgery or procedure as Apigy-5 Tablet may increase the risk of bleeding. Therefore, before having any procedure or any surgery, please inform your doctor that you are taking Apigy-5 Tablet .
Yes, Apigy-5 Tablet helps in reducing the risk of stroke and heart attack by preventing blood clots. Stroke is caused as blood clots break off and travel to brain.
No, you are not recommended to stop taking Apigy-5 Tablet without consulting your doctor as it may worsen the condition. Therefore, take Apigy-5 Tablet for as long as your doctor has prescribed it.
If you have difficulty swallowing the tablet whole, please consult your doctor about alternative methods for taking Apigy-5 Tablet . The tablet can be crushed and mixed with water, 5% glucose in water, apple juice, or apple puree just before consumption.
If you miss a dose of Apigy-5 Tablet , take it as soon as you remember. Take the next dose of Apigy-5 Tablet at the usual time and then continue as normal.
Side effects of Apigy-5 Tablet include nausea, anaemia (lack of blood), and unusual bleeding, including swelling and bruising. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you have atrial fibrillation (a condition in which the heart beats irregularly) and are taking Apigy-5 Tablet to help prevent strokes or serious blood clots, in that case, you may be at a higher risk of having a stroke if you stop taking this medication. Besides this, you may be at risk of having a blood clot form in or around your spine that could cause paralysis if you have epidural or spinal anaesthesia or a spinal puncture while taking a blood thinner such as Apigy-5 Tablet .
Yes, Apigy-5 Tablet is a blood thinner. It belongs to the class of medicines known as factor Xa inhibitors which help prevent the formation of blood clots.
Symptoms of Apigy-5 Tablet overdose are unusual bleeding or bruising; red, brown, or pink urine; red or black, tarry stools; and coughing up or vomiting blood or material that looks like coffee grounds. Consult the doctor if you experience these symptoms or if you have taken an overdose.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - API0136

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