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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:36 PM IST

Aminophylline Injection is used to treat Asthma and Chronic obstructive pulmonary disease (COPD). It contains Aminophylline, which relaxes and opens air passages in the lungs, making breathing easier. Besides this, it relieves various symptoms such as cough, wheezing, shortness of breath, and trouble breathing by increasing airflow through the bronchial tubes. Common side effects of Aminophylline Injection are upset stomach, stomach pain, diarrhoea, headache, restlessness, injection site reactions and irritability.

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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Harson Laboratories

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Aminophylline Injection

Aminophylline Injection belongs to the class of drugs called bronchodilators. It is indicated for the relief of bronchospasm associated with asthma and chronic obstructive pulmonary disease (COPD). Asthma is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty breathing. COPD is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of bronchial tubes).

Aminophylline Injection contains Aminophylline, which helps to relieve bronchospasm associated with asthma and chronic obstructive pulmonary disease (COPD). Aminophylline relaxes and opens air passages in the lungs, making breathing easier.

Aminophylline Injection is usually administered by a qualified healthcare professional; do not self-administer. Aminophylline Injection may cause certain side effects, including upset stomach, stomach pain, diarrhoea, headache, restlessness, injection site reactions and irritability. Most of these side effects of Aminophylline Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before prescribing the Aminophylline Injection, let your doctor know about all your medical conditions, allergic reactions, and all medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Aminophylline Injection may cause insomnia and restlessness; therefore, avoid driving vehicles or operating machinery until you return to normal. Avoid the consumption of tobacco. Smoking may affect the effectiveness of aminophylline.

Uses of Aminophylline Injection

Treatment of Asthma and Chronic obstructive pulmonary disease (COPD)

Medicinal Benefits

Aminophylline Injection contains Aminophylline. It belongs to the class of drugs called bronchodilators. It is indicated to relieve bronchospasm associated with asthma and chronic obstructive pulmonary disease. Aminophylline relaxes and opens air passages in the lungs, making breathing easier. It also relieves various symptoms such as cough, wheezing, shortness of breath, and trouble breathing by increasing airflow through the bronchial tubes.

Directions for Use

Aminophylline Injection will be administered by a trained healthcare professional. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Aminophylline Injection

  • Upset stomach
  • Stomach pain
  • Diarrhea
  • Headache
  • Restlessness
  • Insomnia
  • Irritability
  • Injection site reaction

Drug Warnings

Before receiving Aminophylline Injection, let your doctor know about all your medical conditions, such as if you have or have ever had seizures, heart disease, an overactive or underactive thyroid gland, high blood pressure, or kidney or liver disease or if you have a history of alcohol abuse, allergic reactions (especially aminophylline, theophylline’s, theobromine, caffeine or to any of the excipients present in Aminophylline Injection), and all medication history you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before receiving Aminophylline Injection. Avoid the consumption of tobacco. Smoking may affect the effectiveness of aminophylline.

Drug Interactions

Drug-Drug Interactions: Aminophylline Injection may interact with medicines for heartburn or an ulcer (cimetidine), antibiotics (erythromycin, ciprofloxacin), antifungal (fluconazole) medicines for gout (allopurinol, sulphinpyrazone), medicines for high blood pressure or chest pain (diltiazem, propranolol), antidepressants (fluvoxamine),  medicines for epilepsy or fits (phenytoin, carbamazepine), water pills (furosemide), medicines used heart-related medicines (isoprenaline, digoxin), anthelmintic (thiabendazole),  corticosteroids (prednisone) and oral contraceptives (ethinylestradiol), antimanic agents (lithium), anticancer drugs (interferon alfa, methotrexate), medicines used to reduce the risk of stroke (ticlopidine).

Drug-Food Interactions: Aminophylline Injection may interact with alcohol. Therefore, avoid intake of alcohol with Aminophylline Injection as it may increase drowsiness. St. John’s Wort (antidepressant) and caffeine-containing food or drinks should be avoided as they can affect the working of Aminophylline Injection.

Drug-Disease Interactions: Aminophylline Injection should be used with caution if you have heart problems, overactive thyroid gland (hyperthyroidism), stomach ulcer, liver problems, seizures (fits) or convulsions, fever, viral infection, alcoholism, male and have difficulty in passing urine (due to an enlarged prostate gland).

Drug-Drug Interactions Checker List

  • CIMETIDINE
  • ERYTHROMYCIN
  • CIPROFLOXACIN
  • FLUCONAZOLE
  • ALLOPURINOL
  • DILTIAZEM
  • PROPRANOLOL
  • FLUVOXAMINE
  • PHENYTOIN
  • CARBAMAZEPINE
  • FUROSEMIDE

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy diet, especially green leafy vegetables, and strictly do not consume alcohol or caffeine (coffee, tea, cola drinks, and chocolate).
  • Drink plenty of fluids daily to thin mucus, making it easier to cough out.
  • Smoking should be avoided while receiving Aminophylline Injection as it can alter the blood levels of aminophylline, which may affect the dosing.
  • It is very important to maintain hygiene, like washing hands after coming from outside, as people with asthma or COPD are at a greater risk of infections.
  • Stay active and do regular exercise to improve quality of life and increase tolerance to shortness of breath.
  • Do meditation, deep breathing, regular exercise, and try progressive muscle relaxation techniques to get relief from stress and reduce the risk of an asthma attack.

Special Advise

  • The doctor may suggest some tests to determine the root cause of the respiratory disorder, such as Spirometry (to check the narrowing of bronchial tubes) and Peak flow (to check how difficult it is to exhale).
  • Please avoid the use of Tobacco and Marijuana as it decreases the efficacy of Aminophylline Injection. 
  • If you have a glucose test or lipid profile test, let your doctor know about this, as prolonged use of Aminophylline Injection may increase glucose levels and free fatty acid in the body.

Disease/Condition Glossary

Asthma: It is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. The symptoms of asthma include wheezing (whistling sound while breathing), shortness of breath, chest tightness and cough, especially at night. The symptoms of mild persistent asthma may occur more than two times a week and up to 4 nights a month, whereas, in the case of severe persistent asthma, the symptoms occur several times every day and most nights. The treatment for asthma includes medication, breathing exercises and self-care.

Chronic obstructive pulmonary disease (COPD): It is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of bronchial tubes). The major cause of COPD is smoking tobacco. Also, long-term exposure to fumes and chemicals may lead to COPD. The symptoms include chronic cough, shortness of breath or wheezing (whistle sound while breathing).

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Alcohol

Caution

Alcohol may increase the levels of aminophylline in the blood, leading to serious side effects. Discuss with your doctor if you have concerns.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Aminophylline Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Small amounts of aminophylline are excreted in human milk. Hence, if you are breastfeeding, inform your doctor before receiving Aminophylline Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Aminophylline Injection has no or negligible influence on the ability to drive.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Aminophylline Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Aminophylline Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Kidney disease in an infant less than three months of age may affect the functioning of Aminophylline Injection.

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Children

Caution

Caution should be maintained while using Aminophylline Injection in infants less than three months and with kidney disease. Please consult your doctor. Your doctor may prescribe this medicine for your child if the benefits outweigh the risks.

Country of origin

INDIA

Manufacturer/Marketer address

12, R. C. Patel Industrial Estate, Akota, Baroda - 390 020., India
Other Info - AMI0184

FAQs

Aminophylline Injection is used to treat Asthma and Chronic obstructive pulmonary disease (COPD).
Aminophylline Injection contains Aminophylline, a bronchodilator that relaxes and widens the muscles of the airways, thereby making it easier for asthma and COPD patients to breathe.
Avoid aerated drinks, fried foods, excess salts (sodium chloride or table salt), dairy products, cruciferous veggies, cold cuts, and cured meats. Also, avoid consuming high amounts of caffeine-containing tea, coffee, chocolate, and cola, as these foods already contain aminophylline, an active constituent of Aminophylline Injection. Sulfites in alcoholic beverages can trigger symptoms of asthma and COPD, so avoid consuming alcoholic beverages.
No, you are not recommended to smoke while receiving Aminophylline Injection as it may reduce the effectiveness of Aminophylline Injection and damage your lung's airways (alveoli). Long-term smoking may cause breathing problems like asthma, bronchitis and COPD. Quitting smoking is the best way to keep your lungs healthy.
Aminophylline Injection should be used with caution in patients suffering from fits as it may worsen the condition. Therefore, inform your doctor if you have a history of fits before taking Aminophylline Injection so that the dose may be adjusted or an alternate medicine may be prescribed.
No, Aminophylline Injection does not relieve sudden asthma symptoms. Therefore, it is advised to carry a rescue inhaler always to treat sudden asthma symptoms.
You are not recommended to take Aminophylline Injection with antibiotics such as erythromycin, tetracycline, amoxicillin, amikacin and gentamicin at the same time as it may reduce the effectiveness of antibiotics. However, if you are supposed to take these medicines together, maintain a time gap of a minimum of 2 hours between taking Aminophylline Injection and antibiotics. However, please consult a doctor before using Aminophylline Injection with antibiotics or other medicines.

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