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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 30, 2024 | 3:21 PM IST
Ambrican 5 Tablet is used to treat pulmonary arterial hypertension (high blood pressure in the lungs). It contains Ambrisentan which works by widening the blood vessels and improving blood flow. In some cases, this medicine may cause side effects such as headache, dizziness, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition

AMBRISENTAN-5MG

Manufacturer/Marketer

Lupin Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Ambrican 5 Tablet

Ambrican 5 Tablet is used to treat high blood pressure in the arteries of the lungs (pulmonary arterial hypertension). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the walls of blood vessels. This condition makes the heart work harder in pumping the blood to the whole body. Pulmonary hypertension affects arteries in the lungs and the right side of the heart.

Ambrican 5 Tablet contains ‘Ambrisentan,’ which belongs to the class of ‘endothelin receptor blockers’. Ambrisentan works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. Ambrican 5 Tablet widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply to the lungs, thus lowering the blood pressure.

In some cases, Ambrican 5 Tablet can cause side effects like headache, dizziness, palpitations, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Please inform your doctor if you are using any prescription or non-prescription drugs, including vitamins and herbal products. Let your doctor know if you have any allergic reactions to Ambrican 5 Tablet or any other medicines, before starting Ambrican 5 Tablet . Inform your doctor if you have low blood pressure, lung, heart, kidney or liver problems, and anaemia (lack of blood cells). It is advised to consult a doctor if you are a pregnant or breastfeeding mother. Do not stop taking Ambrican 5 Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. Do not consume alcohol with Ambrican 5 Tablet as it may increase the risk of low blood pressure.

Uses of Ambrican 5 Tablet

Treatment of Pulmonary arterial hypertension.

Medicinal Benefits

Ambrican 5 Tablet is an anti-hypertensive medicine that treats high blood pressure in the arteries of the lungs (pulmonary arterial hypertension (PAH)). It contains ‘Ambrisentan,’ an endothelin receptor blocker. Ambrican 5 Tablet works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. In people with PAH, the pulmonary arteries get narrower making the heart work harder to pump blood through them. Ambrican 5 Tablet widens these constricted arteries and makes it easier for the heart to pump blood, thus lowering the blood pressure.

Directions for Use

Swallow Ambrican 5 Tablet as a whole with a glass of water. You can take it with or without food at regular intervals, as prescribed by the doctor. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Ambrican 5 Tablet

  • Headache
  • Dizziness
  • Swelling in your hands, legs, ankles, or feet
  • Palpitations
  • Breathlessness
  • Chest pain or discomfort
  • Stuffy nose, sinus pain
  • Flushing (redness of the skin)
  • Feeling sick
  • Diarrhoea
  • Feeling tired
  • Rash

Drug Warnings

Brief your medical history if you have heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure) before starting Ambrican 5 Tablet . Ambrican 5 Tablet is contraindicated during pregnancy since it has harmful effects on the foetus. Consult your doctor before using Ambrican 5 Tablet if you are a breastfeeding mother. Complete the course strictly as suggested by the doctor, even if you feel better, to avoid disease recurrence. Do not drive or operate machinery since Ambrican 5 Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Avoid consumption of alcohol with Ambrican 5 Tablet as it may increase the risk of low blood pressure. Ambrican 5 Tablet is not recommended in patients younger than 18 years of age.

Drug Interactions

Drug-Drug Interaction: Ambrican 5 Tablet may interact with other PAH treating medicines (iloprost, epoprostenol), impotence-treating drugs (sildenafil), antibiotics (rifampicin) and immunosuppressants (cyclosporine).

Drug-Food Interaction: Alcohol may increase the side effects of Ambrican 5 Tablet . Hence, it is advised to limit the intake of alcohol while using Ambrican 5 Tablet .

Drug-Disease Interaction: People with heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention), low blood pressure and severe dehydration should consult the doctor before taking Ambrican 5 Tablet .

Drug-Drug Interactions Checker List

  • EPOPROSTENOL
  • SILDENAFIL
  • RIFAMPICIN
  • CYCLOSPORINE
  • ILOPROST

Habit Forming

No

Diet & Lifestyle Advise

  • Reduce sodium intake in your diet to maintain your blood pressure.

  • Eat natural and healthy foods by cutting down on high on sodium processed foods.

  • Lose those extra pounds, since being obese can be a risk factor for hypertension.

  • Exercise regularly to maintain good heart health.

  • Avoid smoking and alcohol intake.

  • Chronic stress may also cause high blood pressure. Therefore, avoid stress triggers and make time for yourself to relax and do activities that you enjoy.

  • Try to include heart-healthy omega 3 fatty acids containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.

  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

Special Advise

  • Keep a check on your daily blood pressure and if you notice any fluctuations, please consult a doctor.
  • You may be asked by your doctor to undergo blood and urine tests if you have been suffering from vomiting or dehydration.
  • If you have diabetes, using Ambrican 5 Tablet may affect your blood sugar levels. Inform your doctor so that your diabetes medication may be adjusted accordingly.
  • Your dietician may prescribe you a suitable exercise program and diet to manage your blood pressure.
  • Your doctor may also suggest liver function tests since Ambrican 5 Tablet may cause a change in liver enzymes.

Disease/Condition Glossary

Hypertension: It is a medical condition in which blood pressure is elevated persistently in the arteries. It is considered an essential risk factor for cardiovascular diseases and can be caused by obesity, diabetes, smoking, high salt intake, stress, lack of physical activity or ageing. Blood pressure is measured in the ratio of systolic pressure to diastolic pressure. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg and diastolic pressure is 90 mm of Hg. The ideal blood pressure range lies between 90/60 mmHg and 120/80 mmHg. If the blood pressure is 140/90 mmHg or greater, it is considered high blood pressure.

Pulmonary Arterial Hypertension: It is referred to as high blood pressure in the blood vessels (the pulmonary arteries) that carry blood from the heart to the lungs. Symptoms include shortness of breath, dizziness, and chest pressure.

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Alcohol

Caution

It is advised to limit alcohol intake, since alcohol consumption with Ambrican 5 Tablet may increase the risk of low blood pressure and cause adverse effects, such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Unsafe

Ambrican 5 Tablet is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. You are advised to get a pregnancy test done before starting Ambrican 5 Tablet . You should get a negative pregnancy test for sure before using Ambrican 5 Tablet . Also, please use reliable forms of birth control if you are undergoing treatment with Ambrican 5 Tablet to avoid pregnancy.

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Breast Feeding

Caution

It is not known if Ambrican 5 Tablet is excreted into the breast milk. Please consult your doctor for more information before taking Ambrican 5 Tablet if you are a nursing mother.

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Driving

Caution

Ambrican 5 Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Ambrican 5 Tablet . Ambrican 5 Tablet may cause an increase in liver enzymes. If you are using Ambrican 5 Tablet and experience any nausea, vomiting, loss of appetite, dark-coloured urine and yellowing of the skin, please see your doctor immediately.

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Kidney

Caution

Ambrican 5 Tablet should be used with caution in cases of renal impairment. It is advised to seek doctor advice before starting Ambrican 5 Tablet if you have any kidney problems.

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Children

Unsafe

Safety and effectiveness of Ambrican 5 Tablet have not been established in patients below 18 years of age.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - AMB0169

FAQs

Ambrican 5 Tablet is used to treat Pulmonary arterial hypertension.
Ambrican 5 Tablet consists of Ambrisentan. It is an anti-hypertensive medicine that lowers the blood pressure by widening the pulmonary arteries and making the heart pump blood efficiently.
Yes, Ambrican 5 Tablet can make you feel dizzy. Dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try rising slowly when you change your posture to relieve from dizziness. If the side effect persists longer, please seek medical help.
Do not stop using Ambrican 5 Tablet even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.
Ambrican 5 Tablet should be used with caution in cases of any allergic reactions, heart failure, liver, kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure).
Store Ambrican 5 Tablet away from direct sunlight and at a temperature not exceeding 30°C. Keep this medicine out of the sight and reach of children.
Ambrican 5 Tablet may rarely cause liver problems. Your doctor will monitor your liver function while you're taking Ambrican 5 Tablet . If you experience symptoms like yellowing skin, dark urine, or abdominal pain, seek medical attention. Discuss any concerns with your doctor.
Take Ambrican 5 Tablet exactly as your doctor tells you to. Typically, it's one tablet once a day. Swallow the tablet whole with water, and take it at the same time each day. Don't crush, chew, or break it.
Don't stop taking Ambrican 5 Tablet without talking to your doctor first. Stopping suddenly can worsen your condition and increase the risk of heart problems. Your doctor will advise you on how to safely stop taking Ambrican 5 Tablet if needed. Follow their instructions carefully.
Ambrican 5 Tablet is used to treat high blood pressure in the lungs, but have risks and limitations. They can cause serious side effects and may not be suitable for everyone, including pregnant women and those with certain medical conditions. Always follow your doctor's instructions and ask questions if needed.
Ambrican 5 Tablet can be effective in treating certain conditions, but in some cases, it can cause serious side effects. Watch out for severe swelling, difficulty breathing or swallowing, and sudden weight gain. Additionally, be aware of extreme tiredness, yellowing of the skin or eyes, dark urine, and severe itching. If you experience any of these symptoms, call your doctor right away or seek emergency medical help. Don't delay; these side effects can be serious and require prompt attention. Discussing the potential risks and benefits with your doctor before starting treatment is essential.
You have been prescribed Ambrican 5 Tablet to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the lungs.
Avoid exceeding the recommended dose, as it could lead to an overdose. Symptoms of overdose may include sweating, confusion, blurred vision, dizziness, light-headedness when getting up suddenly from a sitting/lying position, or faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
Common side effects of Ambrican 5 Tablet may include headache, dizziness, palpitations, breathlessness, runny nose, feeling sick, diarrhoea, and fatigue. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.
No, you should not take Ambrican 5 Tablet on your own without consulting a doctor. This medication is prescribed for specific medical conditions and requires a doctor's supervision to ensure safe and effective use.
Safety and effectiveness of Ambrican 5 Tablet have not been established in patients below 18 years of age.

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