Affydase 5mg Tablet belongs to the class of drugs known as 'non-steroidal anti-inflammatory drug' (NSAID) used to provide pain relief in various conditions, including post-traumatic pain, low back pain, cervical pain, spondylitis (inflammation in spinal bones), osteoarthritis (lifelong joint pain and stiffness), rheumatoid arthritis(joint pain and damage throughout the body). Pain can be temporary (acute) or prolonged period (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone, or organs. Chronic pain lasts for life long, caused due to nerve damage, osteoarthritis, and dental pain due to damage to the tooth nerve, infection, decay, extraction, or injury. 

Affydase 5mg Tablet contains 'serratiopeptidase', a protein enzyme isolated from a bacterial cell found in the silkworms. It breaks the insoluble protein (fibrin), a by-product of blood clots, into smaller units. It also causes thinning of the body's fluids due to injury, making fluid drainage smoother in the swollen tissue and relieving inflammation at the affected or injured site. 

Swallow Affydase 5mg Tablet as a whole with water; do not crush, break or chew it. In some cases, Affydase 5mg Tablet may cause stomach ache, diarrhoea, nausea (feeling sick), and indigestion. Most of these side effects of Affydase 5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Affydase 5mg Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children. Affydase 5mg Tablet may be associated with a small increased risk of heart attack ‘myocardial infarction’. It is advisable not to exceed the recommended dose or duration of treatment. Stop taking this medicine if you experience tightness of the chest, breathing difficulties, fever, skin rashes, mouth sores, and other mucous membranes causing ulcers, or any signs of hypersensitivity (allergy).

Affydase 5mg Tablet plays a vital role in reducing pain and inflammation by blocking the release of chemical messengers that cause pain and fever. Affydase 5mg Tablet relieves pain and inflammation in arthritic conditions with the benefit of increased antibiotic penetration and micro-circulation at the injury site. Affydase 5mg Tablet contains serratiopeptidase, a proteolytic enzyme that helps break the insoluble protein (fibrin) by-product of blood clots into smaller units. It also causes thinning of the fluids in the body due to injury, thereby making fluid drainage smoother in the swollen tissue. 

• Stomach ache
• Diarrhoea
• Nausea (feeling sick)
• Indigestion

Consumption of alcohol should be avoided during the treatment with Affydase 5mg Tablet as it may lead to an increase in the risk of liver damage. Patients with a stomach ulcer, gastric bleeding, severe heart failure, stroke, and hypertension (high blood pressure), should not take Affydase 5mg Tablet. Besides this, it should be avoided during the last trimester of pregnancy, unless there are compelling reasons for doing so. If you have a severe allergy to pain killers and, complications like asthma, rhinitis, angioedema (swelling under the skin), or skin rashes, immediately stop taking Affydase 5mg Tablet. Do not drive or operate heavy machinery as intake of Affydase 5mg Tablet may cause dizziness. Patients who have had recently undergone heart bypass surgery should take Affydase 5mg Tablet with caution and only under medical supervision. Use of Affydase 5mg Tablet is contraindicated in kidney failure patients or who are undergoing dialysis.

Drug-Drug Interaction: Drugs containing pain killers (nimesulide), anti-cancer (methotrexate), lithium, iodine, and blood clotting agents (warfarin) should not be taken with Affydase 5mg Tablet as they can worsen your condition.

Drug-Food Interaction: Drinking alcohol should be avoided while taking Affydase 5mg Tablet as it can cause unpleasant effects.

Drug-Disease Interaction: People with peptic ulcers, gastric bleeding, severe heart failure, stroke, ulcerative colitis, Crohn's disease, alcoholism, and high blood pressure should avoid intake of Affydase 5mg Tablet as it may lead to life-threatening conditions.

• NIMESULIDE
• METHOTREXATE
• LITHIUM
• IODINE
• WARFARIN

• Include more glucosamine, chondroitin sulfate, Vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.
• In the chronic condition of arthritis or joint pain, including fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.
• Your sitting posture is important, especially when have pain and inflammation condition. Try to sit little as possible, and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

• Affydase 5mg Tablet might increase the risk of bleeding during or after the surgery. So, let your doctor know that you are taking Affydase 5mg Tablet before undergoing planned surgery. 

Pain: It can be temporary (acute) or prolonged period (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone, or organs. Chronic pain lasts for life long, caused due to nerve damage, osteoarthritis, and dental pain due to damage to the tooth nerve, infection, decay, extraction, or injury.