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Reviewed By Veda Maddala , M Pharmacy
Adoxi 20mg Injection Combipack is an anti-cancer medicine used in the treatment of breast, lung, prostate, stomach, head/neck cancers. It works by slowing down cell growth, thus preventing the cancer cells from rapidly dividing and spreading. Common side effects include injection site reactions, headache, fatigue, dizziness, drowsiness, constipation, loss of appetite, indigestion, tearing of the eyes, nausea, vomiting, diarrhoea, etc.
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Whats That

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Composition :

DOCETAXEL-20MG

Manufacturer/Marketer :

Adley Formulations

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Adoxi 20mg Injection Combipack

Adoxi 20mg Injection Combipack belongs to the class of 'anti-neoplastic/anti-cancer drugs', primarily used as a chemotherapy drug to treat cancers. It is effectively used in breast, lung, prostate, stomach, head/neck cancers. Cancer is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues.

Adoxi 20mg Injection Combipack contains Docetaxel, which belongs to the anticancer drugs. It works by slowing down cell growth. It is a cytotoxic agent, i.e., it prevents the cancer cells from rapidly dividing and spreading.

Adoxi 20mg Injection Combipack will be administered by a healthcare professional. Your doctor will decide the dosage depending on your medical condition. The common side effects of Adoxi 20mg Injection Combipack include pain/swelling at the injection site, headache, fatigue, dizziness, drowsiness, constipation, loss of appetite, indigestion, tearing of the eyes, nausea, vomiting, diarrhoea, insomnia (sleeplessness), fever (please inform your doctor if you have fever), muscle aches, and breathlessness. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Do not use or stop this medicine if the doctor did not advise you. Before starting Adoxi 20mg Injection Combipack , let your doctor know if you have any allergic reactions, medical history of liver or kidney diseases, heart diseases, blood pressure problems, fits, lung disorders, weak immune system, anemia, low white blood cell count, vision problems, and are receiving chemotherapy. Adoxi 20mg Injection Combipack is not indicated for use in pregnant and breastfeeding women. Adoxi 20mg Injection Combipack may make you feel dizzy and drowsy, hence do not drive or operate machinery. It is not recommended to consume alcohol along with Adoxi 20mg Injection Combipack . Adoxi 20mg Injection Combipack is not recommended for children below two years of age.

Uses of Adoxi 20mg Injection Combipack

Treatment of Cancer

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Adoxi 20mg Injection Combipack contains Docetaxel that belongs to the family of anticancer drugs. It works by slowing down cell growth. It is a cytotoxic agent and prevents cancer cells from rapidly dividing and spreading. Docetaxel may be used alone or in combination with other chemotherapy drugs to treat breast cancer that has spread to the tissues and lymph nodes (locally advanced breast cancer) and other parts (secondary breast cancer). It is also used in prostate cancer that does not respond to hormone treatment. It is further being investigated to treat small cell lung, ovarian, bladder, and pancreatic cancers.

How Adoxi 20mg Injection Combipack Works

Adoxi 20mg Injection Combipack contains Docetaxel, which belongs to the anticancer drugs. It works by slowing down cell growth. It is a cytotoxic agent, i.e., it prevents the cancer cells from rapidly dividing and spreading.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Adoxi 20mg Injection Combipack

  • Pain/swelling at the injection site
  • Headache
  • Fatigue
  • Dizziness
  • Drowsiness
  • Constipation
  • Loss of appetite
  • Indigestion
  • Tearing of the eyes
  • Nausea
  • Vomiting
  • Diarrhoea
  • Insomnia (sleeplessness)
  • Fever (please inform your doctor if you have fever)
  • Muscle aches
  • Breathlessness

What if I have taken an overdose of Adoxi 20mg Injection Combipack

The overdose of Adoxi 20mg Injection Combipack is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Adoxi 20mg Injection Combipack , please inform your doctor immediately.

Drug Warnings

Inform your doctor if you have any allergic reactions to Adoxi 20mg Injection Combipack or other medications. Before starting Adoxi 20mg Injection Combipack , let your doctor know if you have any medical history of allergic reactions, non-small cell lung cancer, liver or kidney diseases, heart diseases (congestive heart failure), blood pressure problems, fits, lung disorders (pulmonary effusions), weak immune system, anemia, low white blood cell count/thrombocytopenia, vision problems, and are already receiving chemotherapy. Adoxi 20mg Injection Combipack can affect the unborn baby when used in pregnancy. It may also have harmful effects on the breastfed infant when used by a lactating mother. Hence, Adoxi 20mg Injection Combipack is not indicated in pregnancy and breastfeeding women. If you are using Adoxi 20mg Injection Combipack , use reliable contraception forms to prevent pregnancy during the course. Adoxi 20mg Injection Combipack can make you feel dizzy and drowsy, thus affecting your mental ability to drive. Do not drive or operate machinery if you are not mentally alert and focused. Avoid alcohol consumption while being treated with Adoxi 20mg Injection Combipack . Adoxi 20mg Injection Combipack is not recommended for patients younger than 18 years of age.

Drug-Drug Interactions

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DocetaxelEtanercept
Severe
DocetaxelThalidomide
Severe

Drug-Drug Interactions

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DocetaxelEtanercept
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
When Etanercept is used with Adoxi 20mg Injection Combipack 0.5 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Adoxi 20mg Injection Combipack 0.5 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not discontinue any medications without a doctor's advice.
DocetaxelThalidomide
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
Taking thalidomide together with Adoxi 20mg Injection Combipack 0.5 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Adoxi 20mg Injection Combipack 0.5 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
DocetaxelErythromycin
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
Erythromycin may significantly increase Adoxi 20mg Injection Combipack 0.5 ml blood levels. This may increase the possibility of Adoxi 20mg Injection Combipack 0.5 ml side effects.

How to manage the interaction:
Although taking erythromycin and ceritinib together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience fatigue, confusion, unusual bruising or bleeding, fever, shivers, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, urination discomfort or burning. Do not discontinue any medications without consulting a doctor.
DocetaxelCladribine
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
The combined use of cladribine with Adoxi 20mg Injection Combipack 0.5 ml can increase the risk of serious infections.

How to manage the interaction:
Taking Adoxi 20mg Injection Combipack 0.5 ml with Cladribine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
DocetaxelVoriconazole
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
Taking Adoxi 20mg Injection Combipack 0.5 ml with Voriconazole may significantly increase the blood levels of Adoxi 20mg Injection Combipack 0.5 ml.

How to manage the interaction:
Although taking Adoxi 20mg Injection Combipack 0.5 ml and Voriconazole together may result in an interaction, they can be taken together if a doctor prescribes it. However, if you experience dizziness, fever, chills, diarrhea, sore throat, muscle pain, shortness of breath, and pain or burning during urination, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
DocetaxelBaricitinib
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
Coadministration of baricitinib and Adoxi 20mg Injection Combipack 0.5 ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Adoxi 20mg Injection Combipack 0.5 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
DocetaxelItraconazole
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
Coadministration of Itraconazole may significantly increase the blood levels of Adoxi 20mg Injection Combipack 0.5 ml.

How to manage the interaction:
Although there is a possible interaction between Adoxi 20mg Injection Combipack 0.5 ml and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
DocetaxelKetoconazole
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
Coadministration of Ketoconazole and Adoxi 20mg Injection Combipack 0.5 ml may significantly increase the blood levels of Adoxi 20mg Injection Combipack 0.5 ml. This may increase risk of side effects.

How to manage the interaction:
Although taking Ketoconazole and Adoxi 20mg Injection Combipack 0.5 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in your coughing, weight loss, red or inflamed skin, body sores, or discomfort or burning when urinating, you should consult a doctor immediately. do not discontinue any medication without consulting a doctor.
DocetaxelCiclosporin
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
Coadministration of Adoxi 20mg Injection Combipack 0.5 ml with ciclosporin may significantly increase the blood levels of Adoxi 20mg Injection Combipack 0.5 ml.

How to manage the interaction:
Although there is a possible interaction between deferasirox and ciclosporin, they can be taken together if your doctor has prescribed them. Contact your doctor immediately if experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
DocetaxelMifepristone
Severe
How does the drug interact with Adoxi 20mg Injection Combipack 0.5 ml:
Co-administration of Adoxi 20mg Injection Combipack 0.5 ml with mifepristone may significantly increase the levels of mifepristone, which may increase the risk of side effects.

How to manage the interaction:
Taking Adoxi 20mg Injection Combipack 0.5 ml with mifepristone together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience symptoms such as pale skin, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in phlegm(coughing fluid), red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a fiber-rich diet and include healthy carbohydrates from fruits, vegetables, and whole grains.
  • Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli, and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
  • Include whole grains, legumes, and follow a plant-based diet. Limiting dietary fats is advised during the breast cancer phase. Instead, include healthy fats, such as olive oil, avocado, nuts, seeds, and fatty fish
  • Avoid grilled meat, red meat, saturated fat found in animal products, milk, and dairy products.
  • Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
  • Eat at regular intervals.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

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Alcohol

Unsafe

It is unsafe to consume alcohol while using Adoxi 20mg Injection Combipack since it may cause increased dizziness and drowsiness. Please consult your doctor for more information.

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Pregnancy

Unsafe

It is unsafe to use Adoxi 20mg Injection Combipack in pregnancy and can have harmful effects on the unborn baby. Use reliable forms of contraception to prevent pregnancy while using Adoxi 20mg Injection Combipack .

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Breast Feeding

Unsafe

Adoxi 20mg Injection Combipack is not recommended during breastfeeding since it may be unsafe for the breastfed infant. Please seek medical advice if you are a nursing mother before starting Adoxi 20mg Injection Combipack .

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Driving

Unsafe

Adoxi 20mg Injection Combipack causes dizziness and drowsiness that may affect your ability to drive. Do not drive or operate machinery if you experience unmanageable side effects with Adoxi 20mg Injection Combipack .

bannner image

Liver

Caution

Please let your doctor know if you have any history of liver diseases or hepatic impairment. Before being treated with Adoxi 20mg Injection Combipack , your doctor may advise you of blood tests to check your liver functioning.

bannner image

Kidney

Caution

Please let your doctor know if you have any history of kidney diseases before starting Adoxi 20mg Injection Combipack .

bannner image

Children

Unsafe

Safety and efficacy of Adoxi 20mg Injection Combipack have not been established in patients younger than 18 years.

FAQs

Adoxi 20mg Injection Combipack belongs to the class of 'anti-neoplastic/anti-cancer drugs', primarily used as a chemotherapy drug to treat cancers. It is effectively used in breast, lung, prostate, stomach, head/neck cancers.

Adoxi 20mg Injection Combipack contains Docetaxel, an anti-neoplastic agent. It prevents the cancer cells from rapidly dividing and spreading, thus slowing down their growth.

Adoxi 20mg Injection Combipack should be used with caution and under doctor's supervision only if you have any medical history of any allergic reactions, liver or kidney diseases, non-small cell lung cancer, heart diseases (congestive heart failure), blood pressure problems, fits, lung disorders (pulmonary effusions (excess fluid around lungs), weak immune system, anemia, low white blood cell count/thrombocytopenia, vision problems, and are already receiving chemotherapy. Let your doctor know if you have any other medical concerns before using Adoxi 20mg Injection Combipack .

During treatment with Adoxi 20mg Injection Combipack , it is essential to look for any signs of swelling (fluid retention/oedema), dizziness/fainting, difficulty in breathing, irregular heartbeat, swelling, pain and tenderness in the abdomen region, blood in stools, skin rashes, easy bleeding or bruising, sores in the mouth or throat or symptoms of infection like fever and sore throat. If you further notice any symptoms that are not manageable or unusual, please seek prompt medical attention.

It is advised to consult your doctor before undergoing any vaccination and take advice accordingly. Also, please avoid contact with people who have recently been vaccinated with the oral polio vaccine.

Adoxi 20mg Injection Combipack might cause serious allergic reactions and fluid retention if you had previously experienced allergic reactions with paclitaxel and cabazitaxel. These medicines contain polysorbate 80, an excipient. If you had any allergic reactions with medicines containing polysorbate 80, Adoxi 20mg Injection Combipack is not recommended. Please consult your doctor for more information.

Adoxi 20mg Injection Combipack is administered through an intravenous (IV) infusion. A healthcare professional usually gives it in a medical facility.

Adoxi 20mg Injection Combipack may cause weight loss due to common side effects such as loss of appetite, nausea, vomiting, diarrhoea, and fatigue. But, in rare cases, some patients may experience fluid retention or increased hunger, which can lead to weight gain. Consult your doctor or pharmacist for personalized guidance if you have concerns about weight changes.

The duration of Adoxi 20mg Injection Combipack treatment varies depending on the type of your cancer, dose of Adoxi 20mg Injection Combipack , and your response to therapy. Typically, it is administered once every 3 weeks. Your doctor will determine the total length of treatment for you based on your specific situation.

No, it is advisable not to drink alcohol while taking Adoxi 20mg Injection Combipack . Drinking alcohol during treatment may cause increased dizziness and drowsiness.

No, Adoxi 20mg Injection Combipack is not available in pill form. It is available in two primary dosage forms: injection and powder for injection.

Before administering Adoxi 20mg Injection Combipack , certain blood tests are required to ensure safe administration. These tests include a Complete Blood Count (CBC) to check blood cell counts, blood urea nitrogen (BUN) and creatinine levels to assess kidney function, liver function tests (LFTs) to evaluate liver health, and electrolyte level checks. Additionally, other tests may be required depending on individual patient needs and medical history. These blood tests help healthcare providers assess kidney and liver function and other vital parameters to ensure that Adoxi 20mg Injection Combipack can be administered safely and effectively. Your healthcare provider will determine the necessary blood tests and monitoring requirements.

Hair loss caused by Adoxi 20mg Injection Combipack is often reversible. While Adoxi 20mg Injection Combipack can cause hair thinning or loss, hair growth returns once treatment is stopped. However, in some cases, hair loss may be permanent. Consult your healthcare provider for guidance and support if you're concerned about hair loss.

Dexamethasone is used with Adoxi 20mg Injection Combipack to avoid toxicities.

Adoxi 20mg Injection Combipack is a chemotherapy medication that belongs to the class of drugs known as anti-neoplastic/anticancer drugs. It is a cytotoxic agent that prevents the cancer cells from rapidly dividing and spreading.

Adoxi 20mg Injection Combipack causes dizziness and drowsiness that may affect your ability to drive. So, do not drive or operate machinery if you experience these.

The common side effects of Adoxi 20mg Injection Combipack may include vomiting, constipation, changes in taste, extreme tiredness, muscle, joint, or bone pain, hair loss, nail changes, increased eye tearing, sores in the mouth and throat, and redness, dryness, or swelling at the injection site. However, these symptoms usually diminish as your body adjusts to the medication. If these symptoms worsen, please consult a doctor for relief.

Adoxi 20mg Injection Combipack is generally considered safe when following your doctor's advice. However, like all medications, it can have side effects and potential interactions with other drugs. It's important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.

Adoxi 20mg Injection Combipack contains Docetaxel, which belongs to the anticancer drugs.

Safety and efficacy of Adoxi 20mg Injection Combipack have not been established in patients younger than 18 years.

Country of origin

India

Manufacturer/Marketer address

Adley Formulation, Sco- 42, Sector 12, Panchkula-134112, Haryana, India
Other Info - ADO0010

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