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Written By ,
Reviewed By Veda Maddala , M Pharmacy
Last Updated Nov 23, 2024 | 4:30 PM IST
Axidoxel 20 Injection is an anti-cancer medicine used in the treatment of breast, lung, prostate, stomach, head/neck cancers. It works by slowing down cell growth, thus preventing the cancer cells from rapidly dividing and spreading. Common side effects include injection site reactions, headache, fatigue, dizziness, drowsiness, constipation, loss of appetite, indigestion, tearing of the eyes, nausea, vomiting, diarrhoea, etc.
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Prescription drug

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Composition

DOCETAXEL-20MG

Manufacturer/Marketer

Axiommax Oncology Pvt Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Axidoxel 20 Injection

Axidoxel 20 Injection belongs to the class of 'anti-neoplastic/anti-cancer drugs', primarily used as a chemotherapy drug to treat cancers. It is effectively used in breast, lung, prostate, stomach, head/neck cancers. Cancer is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues.

Axidoxel 20 Injection contains Docetaxel, which belongs to the anticancer drugs. It works by slowing down cell growth. It is a cytotoxic agent, i.e., it prevents the cancer cells from rapidly dividing and spreading.

Axidoxel 20 Injection will be administered by a healthcare professional. Your doctor will decide the dosage depending on your medical condition. The common side effects of Axidoxel 20 Injection include pain/swelling at the injection site, headache, fatigue, dizziness, drowsiness, constipation, loss of appetite, indigestion, tearing of the eyes, nausea, vomiting, diarrhoea, insomnia (sleeplessness), fever (please inform your doctor if you have fever), muscle aches, and breathlessness. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Do not use or stop this medicine if the doctor did not advise you. Before starting Axidoxel 20 Injection , let your doctor know if you have any allergic reactions, medical history of liver or kidney diseases, heart diseases, blood pressure problems, fits, lung disorders, weak immune system, anemia, low white blood cell count, vision problems, and are receiving chemotherapy. Axidoxel 20 Injection is not indicated for use in pregnant and breastfeeding women. Axidoxel 20 Injection may make you feel dizzy and drowsy, hence do not drive or operate machinery. It is not recommended to consume alcohol along with Axidoxel 20 Injection . Axidoxel 20 Injection is not recommended for children below two years of age.

Uses of Axidoxel 20 Injection

Treatment of Cancer

Medicinal Benefits

Axidoxel 20 Injection contains Docetaxel that belongs to the family of anticancer drugs. It works by slowing down cell growth. It is a cytotoxic agent and prevents cancer cells from rapidly dividing and spreading. Docetaxel may be used alone or in combination with other chemotherapy drugs to treat breast cancer that has spread to the tissues and lymph nodes (locally advanced breast cancer) and other parts (secondary breast cancer). It is also used in prostate cancer that does not respond to hormone treatment. It is further being investigated to treat small cell lung, ovarian, bladder, and pancreatic cancers.

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Axidoxel 20 Injection

  • Pain/swelling at the injection site
  • Headache
  • Fatigue
  • Dizziness
  • Drowsiness
  • Constipation
  • Loss of appetite
  • Indigestion
  • Tearing of the eyes
  • Nausea
  • Vomiting
  • Diarrhoea
  • Insomnia (sleeplessness)
  • Fever (please inform your doctor if you have fever)
  • Muscle aches
  • Breathlessness

Drug Warnings

Inform your doctor if you have any allergic reactions to Axidoxel 20 Injection or other medications. Before starting Axidoxel 20 Injection , let your doctor know if you have any medical history of allergic reactions, non-small cell lung cancer, liver or kidney diseases, heart diseases (congestive heart failure), blood pressure problems, fits, lung disorders (pulmonary effusions), weak immune system, anemia, low white blood cell count/thrombocytopenia, vision problems, and are already receiving chemotherapy. Axidoxel 20 Injection can affect the unborn baby when used in pregnancy. It may also have harmful effects on the breastfed infant when used by a lactating mother. Hence, Axidoxel 20 Injection is not indicated in pregnancy and breastfeeding women. If you are using Axidoxel 20 Injection , use reliable contraception forms to prevent pregnancy during the course. Axidoxel 20 Injection can make you feel dizzy and drowsy, thus affecting your mental ability to drive. Do not drive or operate machinery if you are not mentally alert and focused. Avoid alcohol consumption while being treated with Axidoxel 20 Injection . Axidoxel 20 Injection is not recommended for patients younger than 18 years of age.

Drug Interactions

Drug-Drug Interaction: Axidoxel 20 Injection may interact with antibiotics (itraconazole, erythromycin, rifabutin, metronidazole, tinidazole), HIV drugs (ritonavir), drugs to treat chronic alcoholism (disulfiram), opioid medicines (codeine, hydrocodone), muscle relaxants (carisoprodol, cyclobenzaprine), and anti-allergic medicines (cetirizine, diphenhydramine).

Drug-Food Interaction: Grapefruit and its juice may interact with Axidoxel 20 Injection . Also, avoid alcohol consumption.

Drug-Disease Interaction: Axidoxel 20 Injection should be used with caution in cases of allergic reactions, non-small cell lung cancer, liver or kidney diseases, heart diseases (congestive heart failure), blood pressure problems, fits, lung disorders (pulmonary effusions), weak immune system, anemia, low white blood cell count/thrombocytopenia, vision problems.

Drug-Drug Interactions Checker List

  • ITRACONAZOLE
  • ERYTHROMYCIN
  • RIFABUTIN
  • METRONIDAZOLE
  • TINIDAZOLE
  • RITONAVIR
  • DISULFIRAM
  • CODEINE
  • HYDROCODONE
  • CARISOPRODOL
  • CYCLOBENZAPRINE
  • CETIRIZINE
  • DIPHENHYDRAMINE

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain a fiber-rich diet and include healthy carbohydrates from fruits, vegetables, and whole grains.
  • Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli, and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
  • Include whole grains, legumes, and follow a plant-based diet. Limiting dietary fats is advised during the breast cancer phase. Instead, include healthy fats, such as olive oil, avocado, nuts, seeds, and fatty fish
  • Avoid grilled meat, red meat, saturated fat found in animal products, milk, and dairy products.
  • Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
  • Eat at regular intervals.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.

Special Advise

  • Your doctor may advise regular physical exams and mammograms to rule out the possibility of breast cancer.
  • Self-examine your breasts to check for any lumps monthly.
  • Your doctor may also advise liver function tests to monitor your liver health.
  • Your doctor may advise blood tests and regular examinations of the prostate.

Disease/Condition Glossary

Cancer: It is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer: benign (localized) and metastatic (spread to the whole body). Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation, and stem cell therapy.

Breast cancer:  It is a type of cancer that develops in breast cells stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), in the fatty tissue, or the fibrous connective tissue within the breast. Symptoms include a lump in the breast or tissue thickening which feels different than the normal surrounding tissues, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, unexplained change in shape, size, or appearance of the breast, and a lump or swelling under the arm. 

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Alcohol

Unsafe

It is unsafe to consume alcohol while using Axidoxel 20 Injection since it may cause increased dizziness and drowsiness. Please consult your doctor for more information.

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Pregnancy

Unsafe

It is unsafe to use Axidoxel 20 Injection in pregnancy and can have harmful effects on the unborn baby. Use reliable forms of contraception to prevent pregnancy while using Axidoxel 20 Injection .

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Breast Feeding

Unsafe

Axidoxel 20 Injection is not recommended during breastfeeding since it may be unsafe for the breastfed infant. Please seek medical advice if you are a nursing mother before starting Axidoxel 20 Injection .

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Driving

Unsafe

Axidoxel 20 Injection causes dizziness and drowsiness that may affect your ability to drive. Do not drive or operate machinery if you experience unmanageable side effects with Axidoxel 20 Injection .

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Liver

Caution

Please let your doctor know if you have any history of liver diseases or hepatic impairment. Before being treated with Axidoxel 20 Injection , your doctor may advise you of blood tests to check your liver functioning.

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Kidney

Caution

Please let your doctor know if you have any history of kidney diseases before starting Axidoxel 20 Injection .

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Children

Unsafe

Safety and efficacy of Axidoxel 20 Injection have not been established in patients younger than 18 years.

Country of origin

India

Manufacturer/Marketer address

A/303, Atrium -1, Andheri - Kurla Road, Mumbai 400 059 India
Other Info - AXI0105

FAQs

Axidoxel 20 Injection belongs to the class of 'anti-neoplastic/anti-cancer drugs', primarily used as a chemotherapy drug to treat cancers. It is effectively used in breast, lung, prostate, stomach, head/neck cancers.
Axidoxel 20 Injection contains Docetaxel, an anti-neoplastic agent. It prevents the cancer cells from rapidly dividing and spreading, thus slowing down their growth.
Axidoxel 20 Injection should be used with caution and under doctor's supervision only if you have any medical history of any allergic reactions, liver or kidney diseases, non-small cell lung cancer, heart diseases (congestive heart failure), blood pressure problems, fits, lung disorders (pulmonary effusions (excess fluid around lungs), weak immune system, anemia, low white blood cell count/thrombocytopenia, vision problems, and are already receiving chemotherapy. Let your doctor know if you have any other medical concerns before using Axidoxel 20 Injection .
During treatment with Axidoxel 20 Injection , it is essential to look for any signs of swelling (fluid retention/oedema), dizziness/fainting, difficulty in breathing, irregular heartbeat, swelling, pain and tenderness in the abdomen region, blood in stools, skin rashes, easy bleeding or bruising, sores in the mouth or throat or symptoms of infection like fever and sore throat. If you further notice any symptoms that are not manageable or unusual, please seek prompt medical attention.
It is advised to consult your doctor before undergoing any vaccination and take advice accordingly. Also, please avoid contact with people who have recently been vaccinated with the oral polio vaccine.
Axidoxel 20 Injection might cause serious allergic reactions and fluid retention if you had previously experienced allergic reactions with paclitaxel and cabazitaxel. These medicines contain polysorbate 80, an excipient. If you had any allergic reactions with medicines containing polysorbate 80, Axidoxel 20 Injection is not recommended. Please consult your doctor for more information.
Axidoxel 20 Injection is administered through an intravenous (IV) infusion. A healthcare professional usually gives it in a medical facility.
Axidoxel 20 Injection may cause weight loss due to common side effects such as loss of appetite, nausea, vomiting, diarrhoea, and fatigue. But, in rare cases, some patients may experience fluid retention or increased hunger, which can lead to weight gain. Consult your doctor or pharmacist for personalized guidance if you have concerns about weight changes.
The duration of Axidoxel 20 Injection treatment varies depending on the type of your cancer, dose of Axidoxel 20 Injection , and your response to therapy. Typically, it is administered once every 3 weeks. Your doctor will determine the total length of treatment for you based on your specific situation.
No, it is advisable not to drink alcohol while taking Axidoxel 20 Injection . Drinking alcohol during treatment may cause increased dizziness and drowsiness.
No, Axidoxel 20 Injection is not available in pill form. It is available in two primary dosage forms: injection and powder for injection.
Before administering Axidoxel 20 Injection , certain blood tests are required to ensure safe administration. These tests include a Complete Blood Count (CBC) to check blood cell counts, blood urea nitrogen (BUN) and creatinine levels to assess kidney function, liver function tests (LFTs) to evaluate liver health, and electrolyte level checks. Additionally, other tests may be required depending on individual patient needs and medical history. These blood tests help healthcare providers assess kidney and liver function and other vital parameters to ensure that Axidoxel 20 Injection can be administered safely and effectively. Your healthcare provider will determine the necessary blood tests and monitoring requirements.
Hair loss caused by Axidoxel 20 Injection is often reversible. While Axidoxel 20 Injection can cause hair thinning or loss, hair growth returns once treatment is stopped. However, in some cases, hair loss may be permanent. Consult your healthcare provider for guidance and support if you're concerned about hair loss.
Dexamethasone is used with Axidoxel 20 Injection to avoid toxicities.
Axidoxel 20 Injection is a chemotherapy medication that belongs to the class of drugs known as anti-neoplastic/anticancer drugs. It is a cytotoxic agent that prevents the cancer cells from rapidly dividing and spreading.
Axidoxel 20 Injection causes dizziness and drowsiness that may affect your ability to drive. So, do not drive or operate machinery if you experience these.
The common side effects of Axidoxel 20 Injection may include vomiting, constipation, changes in taste, extreme tiredness, muscle, joint, or bone pain, hair loss, nail changes, increased eye tearing, sores in the mouth and throat, and redness, dryness, or swelling at the injection site. However, these symptoms usually diminish as your body adjusts to the medication. If these symptoms worsen, please consult a doctor for relief.
Axidoxel 20 Injection is generally considered safe when following your doctor's advice. However, like all medications, it can have side effects and potential interactions with other drugs. It's important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.
Axidoxel 20 Injection contains Docetaxel, which belongs to the anticancer drugs.
Safety and efficacy of Axidoxel 20 Injection have not been established in patients younger than 18 years.

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