Adegesic-S Tablet belongs to the class of drugs known as 'non-steroidal anti-inflammatory drug' (NSAID). It is a fixed-dose combination composed of diclofenac and serratiopeptidase. Pain can be temporary (acute) or lifelong (chronic) in nature. Acute pain is for short time caused by damage to the tissues of the muscle, bone, or organs. While, chronic pain lasts for life long caused due to nerve damage, osteoarthritis, and dental pain due to damage of the tooth nerve, infection, decay, extraction, or injury.

Adegesic-S Tablet is used in the reduction of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX) which causes pain and swelling at the injured or damaged tissue. Serratiopeptidase is a proteolytic enzyme which helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue.

You can take Adegesic-S Tablet with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on how often you take Adegesic-S Tablet based on your medical condition. Adegesic-S Tablet may have common side effects like stomach ache, diarrhoea, nausea (feeling sick), and indigestion. Most of these side effects of Adegesic-S Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Do not take Adegesic-S Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children. Adegesic-S Tablet may be associated with a small increased risk of heart attack ‘myocardial infarction. It is advisable not to exceed the recommended dose or duration of treatment.

Adegesic-S Tablet plays a vital role in reducing pain and inflammation by blocking the release of chemical messengers which cause pain and fever. Adegesic-S Tablet relieves pain and inflammation in arthritic conditions with the benefit of increased antibiotic penetration and micro-circulation at the injury site. Serratiopeptidase present in Adegesic-S Tablet is a proteolytic enzyme which helps in the breakdown of insoluble protein (fibrin) a by-product of blood clots into smaller units. It also causes thinning of the fluids in the body as a result of injury, thereby making fluid drainage smoother in the swollen tissue.

• Stomach ache

• Diarrhoea

• Nausea (feeling sick)

• Indigestion

Consumption of alcohol should be avoided during the treatment with Adegesic-S Tablet as it may lead to an increase in the risk of liver damage. Patients with a stomach ulcer, gastric bleeding, severe heart failure, stroke, and hypertension (high blood pressure), should not take Adegesic-S Tablet. Besides this, it should be avoided during the last trimester of pregnancy, unless there are compelling reasons for doing so. If you have a severe allergy to pain killers and, complications like asthma, rhinitis, angioedema (swelling under the skin) or skin rashes, immediately stop taking Adegesic-S Tablet. Do not drive or operate heavy machinery as intake of Adegesic-S Tablet may cause dizziness. Patients who had recently undergone heart bypass surgery should take Adegesic-S Tablet with caution and only under medical supervision. Use of Adegesic-S Tablet is contraindicated in kidney failure patients or who are undergoing dialysis.

• Include more glucosamine, chondroitin sulphate, Vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.

• Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead you can do stretching, low impact aerobic exercise like walking on treadmill, bike riding and swimming. You can also strengthen your muscle strength by lifting light weights.

• In chronic condition of arthritis or joint pain try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize level of chemical called cytokines, which ramp up inflammation.

• Your sitting posture is important especially when have pain and inflammation conditions. Try to sit little as possible, and only for short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a foot rest if required.