Ulinastatin
About Ulinastatin
Ulinastatin belongs to the class of medicine called protease inhibitors. It is used in the treatment of severe sepsis (a condition triggered by an extreme response of the immune system to infections) and acute pancreatitis (inflammation of the pancreas).
Ulinastatin contains Ulinastatin as an active ingredient, which belongs to the protease inhibitor class of drugs. It works by inhibiting serine proteases, including trypsin, chymotrypsin, kallikrein, plasmin, thrombin, factors IXa, Xa, XIa, and XlIa. This helps prevent organ dysfunction.
Ulinastatin may cause certain side effects, such as nausea, vomiting, headache, skin rash, itching, diarrhoea, allergic reactions and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. A trained healthcare professional will administer it. Do not self-administer.
Ulinastatin should be avoided if you are allergic to it or any other components present in it. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, bleeding disorders or respiratory conditions. It is unknown whether Ulinastatin is suitable for use in pregnant and breastfeeding mothers. Hence, inform your doctor if you are pregnant, are planning to become pregnant or are breastfeeding beforehand.
Uses of Ulinastatin
Medicinal Benefits
Ulinastatin contains Ulinastatin as an active ingredient used in the treatment of sepsis and pancreatitis. It belongs to the protease inhibitor class of drugs that works by activating and inhibiting serine proteases, including trypsin, chymotrypsin, kallikrein, plasmin, granulocyte elastase, cathepsin, thrombin, and factors IXa, Xa, XIa, and XlIa. This reduces the pro-inflammatory response due to disease and helps prevent organ dysfunction.
Directions for Use
Storage
Side Effects of Ulinastatin
- Nausea
- Skin rash
- Stomach upset
- Headache
- Vomiting
- Itching
- Diarrhoea
- Pain at the site of injection
- Allergic reactions
Drug Warnings
Ulinastatin should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, bleeding disorders or respiratory conditions. Ulinastatin should be avoided in children as safety and efficacy are not established. It is unknown whether Ulinastatin is suitable for use in pregnant and breastfeeding mothers. Hence, inform your doctor if you are pregnant, are planning to become pregnant or are breastfeeding beforehand.
Drug Interactions
Drug-Drug Interactions: No interactions found.
Drug-Food Interactions: No interactions found.
Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, blood disorders, and pulmonary disorders before receiving Ulinastatin.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption during the treatment as it can increase the adverse effects and worsen the condition.
Pregnancy
cautionLimited data is available on the effect of Ulinastatin in pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Ulinastatin. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Breast Feeding
cautionLimited data is available on the effect of Ulinastatin on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Ulinastatin. You should not breastfeed while on treatment with Ulinastatin.
Driving
cautionUlinastatin will be administered in the hospital setting. Hence, avoid driving.
Liver
consult your doctorIf you have a pre-existing or a history of liver disease, inform your doctor before receiving Ulinastatin. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.
Kidney
consult your doctorIf you have a pre-existing or a history of kidney disease, inform your doctor before receiving Ulinastatin. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.
Children
unsafeUlinastatin is not recommended for use in children as the safety and efficacy are not established.
Habit Forming
Diet & Lifestyle Advise
- Cut back on fried foods and animal fats. Eat lean meats, healthy fats, fruits, vegetables and whole-grain foods. Avoid lactose (milk, ice cream, cheese, yoghurt); fruits like mangoes, apples and plums; legumes; corn syrup, sweeteners; wheat-based bread, cashews and pistachios)
- Avoid taking Ulinastatin with alcohol as there may be an interaction.
- Stay hydrated by drinking plenty of water, as dehydration is often seen after Ulinastatin.
- Hypnotherapy and meditation have also proven very effective in relieving symptoms of IBS and other psychosomatic gastric disorders. Check out such holistic treatments for the same.
- Yoga has also proven very effective in controlling many abdominal diseases and promoting good health and digestion. Try to do yoga at least thrice a week.
Special Advise
- Inform your doctor immediately if you accidentally take an extra dose of Ulinastatin. Common overdose symptoms can include anxiety, hives, shortness of breath, drowsiness, blurred vision, difficulty swallowing, and feeling hyper, agitated or nervous.
- Please know that your doctor may order blood tests to check your tolerance and need a Ulinastatin.
Patients Concern
Disease/Condition Glossary
Sepsis: It is a life-threatening illness caused by the body's response to an infection. Sepsis occurs when chemicals released in the blood to fight infection trigger inflammation in the body. This may lead to a cascade of changes that damage multiple organ systems, leading them to fail, sometimes even resulting in death. Symptoms may include low blood pressure, chills, dizziness, fatigue, fever, flushing, low body temperature, shivering, fast breathing, shortness of breath, etc.
Pancreatitis: Pancreas play an important role in the digestion of food. It produces enzymes which help in the breakdown of food and absorption of nutrients. Swelling of the pancreas is referred to as pancreatitis. It may be of sudden onset, or it may develop as a chronic condition. Symptoms may include nausea, vomiting and abdominal pain. Alcoholics are more prone to this condition.
FAQs
Ulinastatin is used to treat Severe Sepsis and Acute Pancreatitis.
Ulinastatin contains Ulinastatin, which works by inhibiting serine proteases, including trypsin, chymotrypsin, kallikrein, plasmin, thrombin, factors IXa, Xa, XIa, and XlIa. This helps prevent organ dysfunction.
Ulinastatin is safe when used as per the dose and duration advised by a doctor.
Ulinastatin causes side effects such as nausea, skin rash stomach upset, diarrhoea, itching, vomiting, pain at site of injection, and headache. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.
