Gliclazide+metformin+pioglitazone
About Gliclazide+metformin+pioglitazone
Gliclazide+metformin+pioglitazone is used to treat Type 2 diabetes. Type 2 diabetes is a chronic or lifelong condition affecting how your body processes glucose. People with type 2 diabetes either do not produce enough insulin or if at all the insulin is produced, it is unable to perform its function in the body (insulin resistance). Due to this, the blood glucose level increases and symptoms such as frequent urination increased thirst and increased hunger start.
Gliclazide+metformin+pioglitazone contains Gliclazide, metformin and pioglitazone. Gliclazide works by increasing the insulin released by the pancreas. Metformin acts by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects.
In some cases, Gliclazide+metformin+pioglitazone may cause side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and a respiratory infection. Most of these side effects may not require medical attention and resolve gradually overtime. However, talk to the doctor if the side effects persist or worsen.
Do not take Gliclazide+metformin+pioglitazone if you are allergic to any of its components, have diabetic ketoacidosis (excess acids in your blood), type 1 diabetes mellitus or severe kidney/liver disease. Please inform the doctor if you have heart disease, are pregnant, are planning to get pregnant or are breastfeeding. Gliclazide+metformin+pioglitazone may cause lactic acidosis (accumulation of lactic acid in the blood), which requires immediate medical attention. Do not consume alcohol (risk of lactic acidosis) or fast for prolonged periods (risk of hypoglycemia).
Uses of Gliclazide+metformin+pioglitazone
Medicinal Benefits
Gliclazide+metformin+pioglitazone contains Gliclazide, Metformin, and Pioglitazone. Gliclazide increases the production of insulin by acting on the pancreas. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects. Together, Gliclazide+metformin+pioglitazone decreases the elevated blood sugar level after the meal, along with the recommended diet and exercise. Gliclazide+metformin+pioglitazone also helps to prevent serious complications of diabetes such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), loss of sensation in your hands and feet (diabetic neuropathy) or even loss of the foot.
Directions for Use
Storage
Side Effects of Gliclazide+metformin+pioglitazone
- Hypoglycemia
- Taste change
- Nausea (feeling sick)
- Vomiting (falling sick)
- Diarrhoea
- Stomach ache
- Respiratory infection
- Weight gain
- bone fracture
- Numbness
- Vision problems
Drug Warnings
Gliclazide+metformin+pioglitazone may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. It is a life-threatening condition that requires immediate medical attention. Inform your doctor if you have any severe liver or kidney problems, as their normal functioning is required to eliminate excess lactic acid from the body. Do not consume excess alcohol, as it increases the risk of lactic acidosis. It should be used with caution in patients with heart disease as it increases the risk of heart failure.
Drug Interactions
Drug-drug interactions: Inform the doctor if you are taking antifungal agents (miconazole, fluconazole), medications used to treat high blood pressure (ritodrine, salbutamol, bosentan), bile acid sequestrants, drugs used to treat skin inflammation such as corticosteroids, pain killers (phenylbutazone), a medication used to treat mental illness (chlorpromazine), a medication used to reduce urine production (desmopressin), a medication used to treat endometriosis (danazol), antidiabetics (gemfibrozil), and antibiotics (rifampicin).
Drug-food interactions: Taking Gliclazide+metformin+pioglitazone with alcoholic beverages may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis (build-up of lactic acid in the blood) and hypoglycemia.
Drug-disease interactions: Gliclazide+metformin+pioglitazone should be avoided in patients with congestive heart failure (heart-related issues), type I diabetes, liver diseases, kidney diseases, hormonal problems, infectious illnesses and oedema.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAlcohol may increase the risk of side effects and worsen the condition.
Pregnancy
cautionIf you are pregnant, consult your doctor before taking Gliclazide+metformin+pioglitazone. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Breast Feeding
cautionIf you are breastfeeding, consult your doctor before taking Gliclazide+metformin+pioglitazone. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Driving
cautionGliclazide+metformin+pioglitazone may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using Gliclazide+metformin+pioglitazone.
Liver
cautionGliclazide+metformin+pioglitazone should be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose if required based on your condition.
Kidney
cautionGliclazide+metformin+pioglitazone should be taken with caution in patients with kidney diseases. Your doctor may adjust the dose if required based on your condition.
Children
unsafeGliclazide+metformin+pioglitazone is not recommended for use in children below 18 years.
Habit Forming
Diet & Lifestyle Advise
- Eat at regular intervals. Do not take the long gap between a meal or snack.
- Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
- Invest in at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise weekly.
- Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
- Replace refined carbohydrate-containing foods with whole grain foods and increase intake of fruits and veggies and other fibre-enriched foods.
- Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
- Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
- Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
- Keep your blood pressure as normal (120/80) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.
Patients Concern
Disease/Condition Glossary
Type 2 diabetes mellitus: Type 2 diabetes mellitus is a chronic condition characterised by elevated blood glucose levels in the body. It occurs when the body's cells do not respond to insulin or, in later stages, the body does not produce enough insulin. Symptoms include excessive thirst, hunger, fatigue, increased appetite, and dry mouth.
FAQs
Gliclazide+metformin+pioglitazone is used to treat type II diabetes, a chronic or lifelong condition affecting how your body processes glucose.
Gliclazide+metformin+pioglitazone works by increasing the production of insulin by acting on the pancreas, decreasing liver glucose production and intestinal glucose uptake. It also decreases the amount of glucose released by the liver.
Some patients may experience a decline in blood sugar levels lower than normal (hypoglycemia), resulting in sweating, dizziness, headache, confusion, feeling hungry, temporary changes in vision, uneasiness, irritability, and weakness. In such cases, seek medical attention immediately.
Gliclazide+metformin+pioglitazone may cause side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and a respiratory infection. Most of these side effects may not require medical attention and resolve gradually overtime. However, talk to the doctor if the side effects persist or worsen.
Symptoms of hypoglycaemia (low blood sugar) are feeling hungry, dizziness, irritability, sweating, tiredness, and palpitations. If you experience these symptoms consume glucose biscuits, sugar candy or fruit juice.
Include healthy food in your diet, exercise regularly, manage stress with relaxation techniques, and avoid smoking & alcohol consumption.
