Evogliptin+metformin
About Evogliptin+metformin
Evogliptin+metformin is used as an adjunct to diet and exercise to improve glycaemic control in adult patients with type 2 diabetes mellitus. This medication improves glycaemic control in diabetic patients who do not react well to metformin alone. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels rise more than normal.
Evogliptin+metformin is a combination of two medicines: Metformin and Evogliptin. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. On the other side, Evogliptin works by increasing insulin release from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces fasting and post-meal sugar levels. Thereby, Evogliptin+metformin reduces sugar levels in the body.
Take Evogliptin+metformin as prescribed. You are advised to take Evogliptin+metformin for as long as your doctor has advised. In some cases, Evogliptin+metformin may cause nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, if the side effects persist or worsen, consult your doctor.
Do not take Evogliptin+metformin if you are allergic to any of its contents. Evogliptin+metformin may cause lactic acidosis (accumulation of lactic acid in the blood), which requires immediate medical attention. The risk increases if you are previously diagnosed with kidney or liver diseases. Do not consume alcohol (risk of lactic acidosis) or fast for prolonged periods (risk of hypoglycaemia). Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Uses of Evogliptin+metformin
Medicinal Benefits
Evogliptin+metformin is indicated for managing type 2 diabetes with the right diet and exercise. Evogliptin+metformin is a combination of two medicines: Metformin (biguanide) and Evogliptin (dipeptidyl peptidase-4 inhibitor). Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Evogliptin works by increasing insulin release from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces fasting and post-meal sugar levels. Thereby, Evogliptin+metformin reduces sugar levels in the body.
Directions for Use
Storage
Side Effects of Evogliptin+metformin
- Nausea
- Vomiting
- Diarrhoea
- Headache
- Stomach ache
- Respiratory infection
- Indigestion
Drug Warnings
Do not take Evogliptin+metformin if you are allergic to any of its contents. Do not use this medicine if you have heart failure, bladder cancer, or diabetic ketoacidosis (a complication of diabetes). Evogliptin+metformin may cause lactic acidosis (accumulation of lactic acid in the blood), which requires immediate medical attention. The risk increases if you are previously diagnosed with kidney or liver diseases. Do not consume alcohol with Evogliptin+metformin as it may increase the risk of lactic acidosis or fast for prolonged periods as it might increase the risk of hypoglycaemia. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Drug Interactions
Drug-Drug Interactions: Evogliptin+metformin may have interaction with antibiotic medicines (e.g. clarithromycin), steroid medicines ( e.g. prednisolone), diuretics medicines (e.g. furosemide), medicines to treat heart problems and high blood pressure (e.g. enalapril, perindopril), hormones (e.g. testosterone, oestrogen and progesterone) and other diabetes medicines.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Evogliptin+metformin may interact with uncontrolled diabetes, liver/kidney/heart problems, severe infection, severe circulation problems or breathing difficulties.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is advised to avoid alcohol intake since it may worsen the side effects like lactic acidosis and increase the risk of developing low blood sugar levels.
Pregnancy
cautionLimited information is available on the use of Evogliptin+metformin in pregnant women. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.
Breast Feeding
cautionLimited information on the use of Evogliptin+metformin in breastfeeding mothers is available. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.
Driving
cautionIf your blood sugar is too low or too high, your driving ability may be affected. Do not drive if these symptoms appear.
Liver
cautionThere is limited information available on the use of Evogliptin+metformin in patients with liver disease. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Please consult your doctor.
Kidney
cautionLimited information is available on using Evogliptin+metformin in patients with kidney disease. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.
Children
unsafeEvogliptin+metformin is not recommended for people younger than 18 years of age.
Habit Forming
Diet & Lifestyle Advise
Eat at regular intervals. Do not take a long gap between a meal or snack.
Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
Invest in at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise weekly.
Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
Replace refined carbohydrates-containing foods with whole-grain foods. Increase fruits, vegetables and other fibre-enriched foods in your diet.
Reduce saturated fat foods such as chips, crisps, pastries, biscuits, and samosas.
Choose omega-3 fatty acid-containing oils for daily cooking.
Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
Avoid drinking alcohol while on Evogliptin+metformin. It increases the risk of hypoglycaemia (a decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts various organs).
Try to quit smoking and reduce your intake of carbohydrate-rich food like potatoes, rice, mangoes, bread, sugar, etc.
Special Advise
Keep taking Evogliptin+metformin even if your blood sugar levels are controlled.
Take short, frequent meals, and avoid prolonged fasting when taking Evogliptin+metformin. Beware of hypoglycaemia symptoms, including sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience the symptoms mentioned above, immediately consume 5-6 candies, three glucose biscuits, or three teaspoons of honey/sugar and get in touch with your physician. Make sure to carry these with you at all times, especially for long travels.
Patients Concern
Disease/Condition Glossary
Type 2 diabetes mellitus: Type 2 diabetes mellitus is a chronic condition in which blood glucose levels are elevated in the body. Insulin is responsible for the utilization of glucose by the cells. In type 2 diabetes, the body cells do not respond to insulin; in later stages, your body may not produce enough insulin. Symptoms include excessive thirst, excessive hunger, fatigue, increased appetite and dry mouth. If not properly treated, this condition may worsen over time and cause toxic effects.
FAQs
Evogliptin+metformin is used as an adjunct to diet and exercise to improve glycaemic control in adult patients with type 2 diabetes mellitus. This medication improves glycaemic control in diabetic patients who do not react well to metformin alone. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels rise more than usual.
Evogliptin+metformin contains Metformin and Evogliptin. Metformin works by lowering glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin. Evogliptin works by increasing insulin release from the pancreas and decreasing the hormones that raise blood sugar levels. Altogether Evogliptin+metformin reduces sugar levels in the body.
Hypoglycemia refers to low blood glucose levels. Evogliptin+metformin may cause hypoglycemia. Hypoglycemia can occur if you miss or delay your food, drink alcohol, do intense exercise, or take other antidiabetic medicine along with Evogliptin+metformin.
If you feel that your blood sugar levels are dropping, eat glucose tablets or chocolate immediately. This will help to increase your sugar levels instantly. Always carry glucose tablets or sugar candies with you.
Do not discontinue taking Evogliptin+metformin without consulting your doctor. Take Evogliptin+metformin for as long as it has been advised by the doctor. If you experience any difficulty while taking Evogliptin+metformin, consult a doctor.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.
The side effects of Evogliptin+metformin include nausea, vomiting, headache, stomach pain, diarrhoea, and indigestion. If these side effects persist or worsen, please consult your doctor.
Medicines used to secrete insulin or insulin injections raise the risk of hypoglycemia (low blood sugar levels) when taken with metformin. Therefore, inform your doctor if you are on insulin injections before starting Evogliptin+metformin.
There are no human studies conducted to see the effects of Evogliptin+metformin on fertility. However, studies on animals do not show the harmful effects of high doses of evogliptin and metformin on the fertility in both the genders in rats and mice. If you have any concerns regarding this, please discuss with your doctor.
There is no information on role of Evogliptin+metformin in causing cancer as no human studies have been performed. However, animal studies results do not show cancer.
