Valera M 500 Tablet is used as an adjunct to diet and exercise to improve glycaemic control in adult patients with type 2 diabetes mellitus. This medication improves glycaemic control in diabetic patients who do not react well to metformin alone. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels rise more than normal. 

Valera M 500 Tablet is a combination of two medicines: Metformin and Evogliptin. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. On the other side, Evogliptin works by increasing insulin release from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces fasting and post-meal sugar levels. Thereby, Valera M 500 Tablet reduces sugar levels in the body.

Take Valera M 500 Tablet as prescribed. You are advised to take Valera M 500 Tablet for as long as your doctor has advised. In some cases, Valera M 500 Tablet may cause nausea, vomiting, diarrhoea, headache, stomach ache, respiratory infection, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, if the side effects persist or worsen, consult your doctor.

Do not take Valera M 500 Tablet if you are allergic to any of its contents. Valera M 500 Tablet may cause lactic acidosis (accumulation of lactic acid in the blood), which requires immediate medical attention. The risk increases if you are previously diagnosed with kidney or liver diseases. Do not consume alcohol (risk of lactic acidosis) or fast for prolonged periods (risk of hypoglycaemia). Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Valera M 500 Tablet is indicated for managing type 2 diabetes with the right diet and exercise. Valera M 500 Tablet is a combination of two medicines: Metformin (biguanide) and Evogliptin (dipeptidyl peptidase-4 inhibitor). Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Evogliptin works by increasing insulin release from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces fasting and post-meal sugar levels. Thereby, Valera M 500 Tablet reduces sugar levels in the body.

• Nausea
• Vomiting
• Diarrhoea
• Headache
• Stomach ache
• Respiratory infection
• Indigestion

Do not take Valera M 500 Tablet if you are allergic to any of its contents. Do not use this medicine if you have heart failure, bladder cancer, or diabetic ketoacidosis (a complication of diabetes). Valera M 500 Tablet may cause lactic acidosis (accumulation of lactic acid in the blood), which requires immediate medical attention. The risk increases if you are previously diagnosed with kidney or liver diseases. Do not consume alcohol with Valera M 500 Tablet as it may increase the risk of lactic acidosis or fast for prolonged periods as it might increase the risk of hypoglycaemia. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Drug-Drug Interactions: Valera M 500 Tablet may have interaction with antibiotic medicines (e.g. clarithromycin), steroid medicines ( e.g. prednisolone), diuretics medicines (e.g. furosemide), medicines to treat heart problems and high blood pressure (e.g. enalapril, perindopril), hormones (e.g. testosterone, oestrogen and progesterone) and other diabetes medicines.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Valera M 500 Tablet may interact with uncontrolled diabetes, liver/kidney/heart problems, severe infection, severe circulation problems or breathing difficulties.

• CLARITHROMYCIN
• PREDNISOLONE
• FUROSEMIDE
• ENALAPRIL
• PERINDOPRIL
• TESTOSTERONE
• PROGESTERONE
• OESTROGEN

• Eat at regular intervals. Do not take a long gap between a meal or snack.

• Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.

• Invest in at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise weekly.

• Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).

• Replace refined carbohydrates-containing foods with whole-grain foods. Increase fruits, vegetables and other fibre-enriched foods in your diet.

• Reduce saturated fat foods such as chips, crisps, pastries, biscuits, and samosas.

• Choose omega-3 fatty acid-containing oils for daily cooking. 

• Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.

• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).

• Avoid drinking alcohol while on Valera M 500 Tablet . It increases the risk of hypoglycaemia (a decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts various organs).

• Try to quit smoking and reduce your intake of carbohydrate-rich food like potatoes, rice, mangoes, bread, sugar, etc.

• Keep taking Valera M 500 Tablet even if your blood sugar levels are controlled.

• Take short, frequent meals, and avoid prolonged fasting when taking Valera M 500 Tablet . Beware of hypoglycaemia symptoms, including sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience the symptoms mentioned above, immediately consume 5-6 candies, three glucose biscuits, or three teaspoons of honey/sugar and get in touch with your physician. Make sure to carry these with you at all times, especially for long travels.

Type 2 diabetes mellitus: Type 2 diabetes mellitus is a chronic condition in which blood glucose levels are elevated in the body. Insulin is responsible for the utilization of glucose by the cells. In type 2 diabetes, the body cells do not respond to insulin; in later stages, your body may not produce enough insulin. Symptoms include excessive thirst, excessive hunger, fatigue, increased appetite and dry mouth. If not properly treated, this condition may worsen over time and cause toxic effects.