Seplyser Syrup is a urinary alkaliser indicated for the treatment of renal tubular acidosis, gout and kidney stones. Kidney stones are small, hard deposits made up of calcium, phosphate and other minerals/acid salts that stick together in concentrated urine. Renal tubular acidosis is a condition in which the kidneys fail to excrete acids into the urine; this causes the blood to remain too acidic.
 
Seplyser Syrup contains disodium hydrogen citrate, which metabolises to bicarbonate and increases the excretion of free bicarbonate ions; this increases the solubility of cysteine in the urine and ionises uric acid to soluble urate ion. This helps in increasing the urinary pH, thereby making the urine less acidic. 
 
You are advised to take Seplyser Syrup for as long as your doctor has suggested it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as abdominal discomfort, diarrhoea, tiredness, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Seplyser Syrup if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Seplyser Syrup. It is not known if Seplyser Syrup affects your ability to drive; drive only if you are alert. Talk to a doctor before giving Seplyser Syrup to children. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Seplyser Syrup is a urinary alkaliser indicated for the treatment of renal tubular acidosis, gout and kidney stones. Seplyser Syrup contains disodium hydrogen citrate, which metabolises to bicarbonate and increases the excretion of free bicarbonate ions; this increases the solubility of cysteine in the urine and ionises uric acid to soluble urate ion. This helps in increasing the urinary pH, thereby making the urine less acidic. Seplyser Syrup may also help to treat urinary tract infections.

• Abdominal discomfort
• Diarrhoea
• Tiredness
• Vomiting
• Nausea

Do not take Seplyser Syrup if you are allergic to any of its contents. Inform your doctor if you have hyperkalaemia (high levels of potassium), hypocalcaemia (low blood calcium levels), high blood pressure, oedema, increased alkalinity in the blood, urinary tract infection, or kidney dysfunction. Consult your doctor before taking Seplyser Syrup if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Seplyser Syrup. It is not known if Seplyser Syrup affects your ability to drive; drive only if you are alert. Talk to a doctor before giving Seplyser Syrup to children.

Drug-Drug Interactions: Seplyser Syrup may interact with diuretics (furosemide), antibiotics (tetracycline), anti-arrhythmic (quinidine), adrenergic agonist (ephedrine), decongestant (pseudoephedrine), barbiturates, salicylates, and corticosteroids.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have hyperkalaemia (high levels of potassium), hypocalcaemia (low blood calcium levels), high blood pressure, oedema, increased alkalinity in the blood, urinary tract infection, or kidney dysfunction.

• FUROSEMIDE
• TETRACYCLINE
• QUINIDINE
• EPHEDRINE
• PSEUDOEPHEDRINE

• Drink plenty of fluids as they help in flushing out excess minerals.

• Limit salt intake. High amounts of salt can increase the risk of kidney stones.

• Maintain a healthy weight by exercising regularly.

• Avoid foods rich in oxalates such as spinach, nuts, okra, dates, avocado, hot chocolate, cocoa, baked potato, French fries, and cereals, as they might increase the risk of oxalate stones.

• Seplyser Syrup might interfere with urine ketone test. Inform the person doing the test that you are taking Seplyser Syrup.

Kidney stones: Nephrolithiasis, also known as kidney stones, is a disease affecting the urinary tract. Kidney stones are small, hard deposits made up of calcium, phosphate and other minerals/acid salts that stick together in concentrated urine. They are the common cause of blood in urine and can be painful when passing through the urinary tract. Symptoms include severe pain, usually in one side of the abdomen and nausea. 

Renal tubular acidosis: It is a condition that involves the accumulation of acid in the body due to the failure of the kidneys to alkalise the urine appropriately. The kidneys fail to excrete acids into the urine, which causes the blood to remain too acidic. If not treated, it could lead to kidney stones, bone disease, kidney disease or failure.