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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Metacin 250 mg Suppositories is an antipyretic and analgesic medicine used in the treatment of mild to moderate pain and fever in adults and children. This medicine contains paracetamol which works by inhibiting the release of chemical messengers called prostaglandins that cause pain and inflammation. Some of the common side effects include rash, soreness in or around the rectum/anus, and itching.
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Composition :

PARACETAMOL-250MG

Manufacturer/Marketer :

Themis Medicare Ltd

Consume Type :

RECTAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Metacin 250 mg Suppositories

Metacin 250 mg Suppositories belongs to the group of analgesics (pain killers), and antipyretics (fever-reducing agents) used to treat mild to moderate pain and fever in adults and children weighing at least 7kgs. Pain and fever are caused by the activation of pain receptors due to the release of certain natural chemicals in the body like prostaglandins. 

Metacin 250 mg Suppositories contains 'Paracetamol' which prevents the release of chemical messengers (prostaglandins) that cause pain and inflammation. Thus, relieves pain. Metacin 250 mg Suppositories also acts as an antipyretic agent by affecting the chemical messengers in the brain that regulate body temperature. Thereby, reduces fever.

Your doctor will decide the dose and duration of Metacin 250 mg Suppositories based on your condition. In some cases, Metacin 250 mg Suppositories may cause side effects like rash, soreness in or around the rectum/anus, and itching. Most of these side effects do not necessitate medical attention and will resolve gradually over time. However, if the side effects persist or worsen, please consult a doctor.

Do not take Metacin 250 mg Suppositories if you are allergic to any of its components. Inform your doctor if you have kidney or liver problems, alcoholism, infections or any other medical conditions. Consult your doctor if you are pregnant or breastfeeding. Do not exceed the recommended dosage as an overdose may be injurious to the liver. Do not swallow Metacin 250 mg Suppositories; it is for anal administration only.

Uses of Metacin 250 mg Suppositories

Treatment of Pain and Fever

Directions for Use

Use Metacin 250 mg Suppositories exactly as advised by the doctor. The suppository should be inserted into the rectum (back passage) by removing the plastic wrapper. Wash your hands before and after inserting the suppository.

Medicinal Benefits

Metacin 250 mg Suppositories belongs to the group of analgesics (pain killers), and antipyretics (fever-reducing agents) used to treat mild to moderate pain and fever in adults and children weighing at least 7kgs. Metacin 250 mg Suppositories prevents the release of chemical messengers (prostaglandin) that cause pain and inflammation. Thus, relieves pain. Metacin 250 mg Suppositories also acts as an antipyretic agent by affecting the chemical messengers in the brain that regulate body temperature. Thereby, reduces fever. 

How Metacin 250 mg Suppositories Works

Metacin 250 mg Suppositories contains 'Paracetamol' which prevents the release of chemical messengers (prostaglandins) that cause pain and inflammation. Thus, relieves pain. Metacin 250 mg Suppositories also acts as an antipyretic agent by affecting the chemical messengers in the brain that regulate body temperature. Thereby, reduces fever.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Metacin 250 mg Suppositories

  • Rash
  • Itching
  • Soreness in or around the rectum/anus

What if I have taken an overdose of Metacin 250 mg Suppositories

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include nausea, vomiting, loss of appetite, sweating, extreme tiredness, unusual bleeding or bruising, flu-like symptoms, yellowing of the skin or eyes, and pain in the upper right part of the stomach. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Metacin 250 mg Suppositories if you are allergic to any of its components, have severe liver problems or if the child weighs below 7kgs. Inform your doctor if you have kidney or liver problems, inherited metabolic disease, alcoholism, infections or any other medical conditions. Consult your doctor if you are pregnant or breastfeeding. Do not exceed the recommended dosage as an overdose may be injurious to the liver. Do not swallow Metacin 250 mg Suppositories; it is for anal administration only.

Drug-Drug Interactions

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ParacetamolKetamine
Severe
ParacetamolLeflunomide
Severe

Drug-Drug Interactions

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ParacetamolKetamine
Severe
How does the drug interact with Metacin Suppositories 5's:
Co-administration of ketamine and Metacin Suppositories 5's may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Metacin Suppositories 5's together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolLeflunomide
Severe
How does the drug interact with Metacin Suppositories 5's:
Co-administration of Metacin Suppositories 5's and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories 5's and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Metacin Suppositories 5's:
Co-administration of Mipomersen with Metacin Suppositories 5's may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Metacin Suppositories 5's and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with Metacin Suppositories 5's:
Co-administration of Metacin Suppositories 5's and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories 5's and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Metacin Suppositories 5's:
Co-administration of Metacin Suppositories 5's may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Metacin Suppositories 5's, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolLomitapide
Severe
How does the drug interact with Metacin Suppositories 5's:
Co-administration of Lomitapide and Metacin Suppositories 5's may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories 5's and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolTeriflunomide
Severe
How does the drug interact with Metacin Suppositories 5's:
Co-administration of Teriflunomide with Metacin Suppositories 5's may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Metacin Suppositories 5's with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolValdecoxib
Severe
How does the drug interact with Metacin Suppositories 5's:
Co-administration of Metacin Suppositories 5's and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Metacin Suppositories 5's and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Rest well, and get plenty of sleep.
  • Stay hydrated; drink plenty of water.
  • Mild exercises such as jogging and walking are helpful for muscle stretching.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Hot or cold therapy can help treat pain. Apply an ice pack or hot pack on the muscle for 15-20minutes.

Habit Forming

No

Therapeutic Class

ANALGESIC AND ANTIPYRETIC AGENT

Metacin 250 mg Suppositories Substitute

Substitutes safety advice
  • Aquris Parasyp 250 Paediatric Oral Suspension 60 ml

    0.63per tablet
  • P 250 Suspension 60 ml

    0.68per tablet
  • Calpol-250 mg Oral Suspension 60 ml

    0.68per tablet
  • Dolo 250 Suspension 60 ml

    0.68per tablet
  • Neomol 250 Anal Suppository 5's

    19.54per tablet
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Alcohol

Caution

It is not known if alcohol affects Metacin 250 mg Suppositories. Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Please consult your doctor if you are pregnant; your doctor will prescribe Metacin 250 mg Suppositories only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding; your doctor will decide if Metacin 250 mg Suppositories can be taken by lactating mothers or not.

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Driving

Safe if prescribed

Metacin 250 mg Suppositories is unlikely to affect your ability to drive.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have liver problems or any concerns regarding this. Avoid using Metacin 250 mg Suppositories if you have severe liver problems.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Safe if prescribed

Metacin 250 mg Suppositories is safe for use in children if prescribed by the doctor.

FAQs

Metacin 250 mg Suppositories belongs to the group of analgesics (pain killers), and antipyretics (fever-reducing agents) used to treat mild to moderate pain and fever in adults and children.
Metacin 250 mg Suppositories prevents the release of chemical messengers (prostaglandins) that cause pain and inflammation. Thus, relieves pain.
Metacin 250 mg Suppositories acts as an antipyretic agent by affecting the chemical messengers in the brain that regulate body temperature. Thereby, reduces fever.
Consult your doctor before taking Metacin 250 mg Suppositories with warfarin or blood thinners as taking them together may increase the risk of bleeding.
Avoid using Metacin 250 mg Suppositories for longer durations as it may cause headache. Also, do not exceed the recommended dosage as an overdose may be injurious to the liver.
Metacin 250 mg Suppositories when taken with zidovudine (anti-viral medication) might lower the white blood cell count. Therefore, consult your doctor before taking Metacin 250 mg Suppositories with other medicines.

Country of origin

India

Manufacturer/Marketer address

11/12, Udyog Nagar, S. V. Road, Goregaon (W), Mumbai- 400104.
Other Info - MET1277

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