Karol-0.25 Tablet belongs to a group of medicines called 'vitamin D metabolites' primarily used to treat low blood calcium levels. Karol-0.25 Tablet effectively treats various conditions caused by low calcium levels in the body, such as osteoporosis (weak and brittle bones), osteomalacia/rickets (weak bones), hypoparathyroidism (low levels of parathyroid hormone), and latent tetany (a muscle disease with low blood calcium levels). Karol-0.25 Tablet can also be given to pregnant, nursing, and postmenopausal women to ensure that they are getting enough calcium. Additionally, Karol-0.25 Tablet is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people with chronic kidney disease, surgery, or other conditions.

Karol-0.25 Tablet contains Calcitriol (Vitamin D3); it is used to prevent or treat a calcium deficiency. It is an essential nutrient to maintain bone formation and maintenance. Calcitriol is a synthetic version of Vitamin D3 and treats calcium deficiency with hypoparathyroidism (the parathyroid gland's decreased activity) and metabolic bone diseases in people with chronic kidney failure. It raises Vitamin D levels and thereby increases calcium levels in the blood. This helps in improving the absorption rate of calcium from the intestine.

Take Karol-0.25 Tablet as prescribed by your doctor. Depending on your medical condition, you are advised to take Karol-0.25 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Karol-0.25 Tablet can cause side effects like constipation, stomach upset, nausea, vomiting, loss of appetite, mood changes, weakness, tiredness, fast or pounding heartbeat, bone/muscle pain, and headache. Most of these side effects of Karol-0.25 Tablet do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

If you are known to be allergic to Karol-0.25 Tablet or its inactive components, please inform your doctor. Pregnant or breastfeeding women should consult their doctor before taking Karol-0.25 Tablet . Higher doses of Vitamin D than the recommended daily dose should be used in pregnant women only when advised by the doctor. Karol-0.25 Tablet may pass into the breast milk. Hence, breastfeeding mothers need to seek medical advice before starting Karol-0.25 Tablet . Do not take Karol-0.25 Tablet if you have hypercalcemia (high calcium levels), hypervitaminosis D (high vitamin D levels), and malabsorption syndrome (difficulty absorbing nutrition from food). Inform your doctor if you have any heart/kidney/liver/blood vessel diseases, kidney stones, sarcoidosis (growth of inflammatory cells in different parts of the body), Crohn's disease (inflammatory bowel disease), Whipple's disease (bacterial infection affecting joints and digestive system), achlorhydria (little or no stomach acid), low levels of bile, and phosphate imbalance.

Karol-0.25 Tablet effectively treats various conditions caused by low calcium levels in the body, such as osteoporosis (weak and brittle bones), osteomalacia/rickets (weak bones), hypoparathyroidism (low levels of parathyroid hormone), and latent tetany (a muscle disease with low blood calcium levels). Karol-0.25 Tablet can also be given to pregnant, nursing, and postmenopausal women to ensure that they are getting enough calcium. Additionally, Karol-0.25 Tablet is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people with chronic kidney disease, surgery, or other conditions.

• Hypercalcaemia (high calcium levels in the blood)
• Loss of appetite
• Weight loss
• Feeling sick
• Being sick
• Headache and feeling sluggish
• Drowsy or weak
• Stomach pain or discomfort
• Urinary tract infection
• Rash

Before taking Karol-0.25 Tablet , inform your doctor if you are undergoing hemodialysis due to kidney problems and have a stent in the heart. Karol-0.25 Tablet may alter calcium levels, so it is recommended to monitor calcium levels in the blood and urine regularly. Inform your doctor immediately if you notice fever, increased thirst and urination, dehydration, bedwetting, constipation, and stomach pain, as they may sign very high calcium levels in your blood. Pregnant or breastfeeding women should consult their doctor before taking Karol-0.25 Tablet . Higher doses of Vitamin D than the recommended daily dose should be used in pregnant women only when advised by the doctor. Karol-0.25 Tablet may pass into the breast milk. Hence, breastfeeding mothers need to seek medical advice before starting Karol-0.25 Tablet . Do not take Karol-0.25 Tablet if you have hypercalcemia (high calcium levels), hypervitaminosis D (high vitamin D levels), and malabsorption syndrome (difficulty absorbing nutrition from food).

Drug-Drug interactions: Karol-0.25 Tablet may interact with other medicines containing vitamin D, Steroid medicines (hydrocortisone, prednisolone, dexamethasone), a medicine used to treat high levels of cholesterol in your blood (cholestyramine), medications containing magnesium, such as antacids (used to treat indigestion), medicines used to treat heart disease (digoxin or digitoxin), and diuretic medicines (bendroflumethiazide, chlortalidone, indapamide)

Drug-Food interactions: Do not take foods enriched with vitamin D and avoid a high intake of dairy products such as milk, ghee, and cheese.

Drug-Disease interactions: Karol-0.25 Tablet is not recommended for use in patients with bleeding disorders, hypercalcemia (high levels of calcium in the blood), metastatic calcification (extra deposits of calcium in the body), kidney problems, high blood pressure, cancer, optic nerve damage, and high levels of vitamin D.

• HYDROCORTISONE
• PREDNISOLONE
• CHOLESTYRAMINE
• DIGOXIN
• DIGITOXIN
• BENDROFLUMETHIAZIDE
• CHLORTALIDONE
• INDAPAMIDE

• Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
• Eat a serving of broccoli, cabbage, bok choy, spinach, and other green leafy vegetables daily.
• Snack on calcium-rich nuts like Brazil nuts or almonds.
• Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
• Avoid or reduce the intake of caffeine, soft drinks, and alcohol that inhibit calcium absorption.
• Replace the meat with tofu or tempeh for extra calcium in your food.

• Karol-0.25 Tablet is not indicated in patients with or with a history of kidney stones, as it may increase the chance of kidney stone formation. Consult your doctor for further advice.
• Your doctor may advise regular monitoring of calcium levels.

Osteoporosis: Osteoporosis is a bone disease that weakens and brittle bones by decreasing bone density. As bones become less dense, they weaken and are more likely to break. Breaking a bone is a serious complication of osteoporosis, especially in older patients. Women are much more likely to develop osteoporosis than are men. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, a bone that breaks much more quickly than expected.

Osteomalacia/Rickets: A bone disease caused by softening and weakening bones in children due to inadequate vitamin D. Adults can experience a similar condition known as osteomalacia. It causes bone pain, poor growth, and soft, weak bones that can lead to bone deformities.

Tetany: A disease condition due to low calcium levels (hypocalcemia) in the body causes cramps and spasms in the hands, feet, and larynx (voice box).