Zulfy-O Plus Tablet belongs to the class of medicines called ‘antidiarrheal’ used to treat diarrhea that occurs due to infections. Diarrhea is a condition in which bowel movements are too frequent, leading to loose and watery stools. In general, infection of the digestive tract is the common cause of diarrhea. Different types of bacteria can cause infection.

Zulfy-O Plus Tablet contains Ofloxacin, Ornidazole, and Lactobacillus. Ofloxacin is a quinolone antibiotic and inhibits DNA gyrase required for the replication, transcription, and repair of the DNA of the bacteria. Ornidazole inhibits protein synthesis and leads to cell death, thereby kills the bacteria. Lactobacillus restores the good bacteria in the gut, which is destroyed by the antibiotic. Together, Zulfy-O Plus Tablet helps in treating bacterial infections.

You should take this medicine exactly as prescribed by the doctor. The common side-effects of Zulfy-O Plus Tablet are nausea, vomiting, abdominal pain, bloating, dizziness, headache, and photosensitivity (skin sensitivity to the sun). These side-effects are usually mild and temporary. However, if any of these side-effects persist or get worse, inform your doctor immediately.

It is recommended not to take Zulfy-O Plus Tablet if you are allergic to any contents of it. Zulfy-O Plus Tablet should not be used in patients with fits, history of inflammation or swelling of the tendons in the wrist or Achilles tendon with quinolone antibiotics such as ciprofloxacin, norfloxacin, and glucose-6-phosphate dehydrogenase (G6PD) deficiency (an inherited disorder that affects red blood cells). Do not discontinue or abruptly stop the medication as it may lead to antibiotic resistance, a condition in which bacteria become resistant to antibiotics. It is not recommended for children and adolescents under 18 years, pregnant women, and breastfeeding mothers. It should be used with caution in elderly people.

Zulfy-O Plus Tablet is used to treat diarrhea caused by infection of the digestive tract. It can effectively control bowel movements, treat infection, and prevent the recurrence of symptoms. It is usually prescribed along with fluid and electrolyte therapy. It is also advised to take plenty of fluids to prevent dehydration.

• Nausea
• Vomiting
• Abdominal pain
• Bloating
• Dizziness
• Headache
• Photosensitivity (skin sensitivity to the sun)
• Tendon damage and rupture

Before taking Zulfy-O Plus Tablet, inform your doctor if you have epilepsy, low potassium levels, nervous or muscle problems, head injury or brain tumor, diabetes, rheumatoid arthritis, heart, kidney, or liver problems. Zulfy-O Plus Tablet may increase muscle weakness, so it should be used with caution in patients with myasthenia gravis. If your eyesight is impaired or you notice any vision changes, inform your doctor immediately. Zulfy-O Plus Tablet may increase skin sensitivity to the sun, avoid sunlamps, tanning beds, and prolonged exposure to sunlight while using this medicine. If you notice tingling sensation or numbness in the hands and feet, pain, tenderness, or restricted movement of the tendons, stop taking this medicine and inform your doctor immediately.

Drug-Drug Interactions: Zulfy-O Plus Tablet may have interaction with pain killers (aspirin, ibuprofen), antibiotics (azithromycin, sulfamethoxazole, trimethoprim, metronidazole, erythromycin), a steroid medicine (dexamethasone), anti-diabetic (metformin), medicines that suppress the immune system (azathioprine and cyclosporine), a medicine used to treat breathing problems (albuterol), and water pill (furosemide).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Zulfy-O Plus Tablet should be used with caution in patients with colitis (inflammation in the lining of the colon), tendonitis (inflammation in tendons), disorders associated with brain and spinal cord, myasthenia gravis (neuromuscular disease), peripheral neuropathy (nerve pain), crystalluria (cloudy urine), diabetes, kidney, liver, and heart problems.

• ASPIRIN
• IBUPROFEN
• AZITHROMYCIN
• SULFAMETHOXAZOLE
• TRIMETHOPRIM
• METRONIDAZOLE
• ERYTHROMYCIN
• DEXAMETHASONE
• METFORMIN
• AZATHIOPRINE
• CYCLOSPORINE
• ALBUTEROL
• FUROSEMIDE

• Antibiotics can alter the useful bacteria in the stomach, which helps indigestion. Therefore, you are advised to take foods rich in probiotics such as yogurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk natto, and cheese.
• Eat fiber-rich food like whole grains, beans, lentils, berries, broccoli, peas, and bananas.
• Avoid foods rich in calcium, grapefruit, and grapefruit juice as they might hinder antibiotic absorption.
• Avoid consumption of alcohol to treat your condition effectively.
• Avoid usage of tobacco.
• To cure your condition, effectually complete the full course of Zulfy-O Plus Tablet even though you find symptomatic relief.

• If you have been taking antacids, and zinc or iron tablets along with Zulfy-O Plus Tablet, maintain a minimum gap of two hours between Zulfy-O Plus Tablet and antacid or iron tablets.
• Zulfy-O Plus Tablet may affect coagulation test or prothrombin time (time is taken for blood clotting), liver function tests, and serum tests. So, let your doctor know that you are taking Zulfy-O Plus Tablet before undergoing these tests.
• Zulfy-O Plus Tablet contains ofloxacin which might produce false-positive urine screening results for opiates. Inform the person doing the tests that you are taking Zulfy-O Plus Tablet.
• Do not stop taking this medicine even if you feel better and not take this medicine on your own. It may cause antibiotic resistance (a condition in which bacteria become resistant to antibiotics).

Diarrhoea: It is characterized by loose and watery stools with a frequent need to have a bowel movement. Diarrhoea might be a result of bacterial infection. It can be acute (lasts for a few days) or chronic (lasts for a few weeks). Diarrhoea can lead to loss of water along with salts, electrolytes, and minerals from the body. The common causes of diarrhoea include food intolerance, food allergy, adverse reaction to a medication, or infections. Symptoms include nausea, abdominal pain, cramps, bloating, dehydration, watery loose stools, and frequent urge to evacuate the bowels.