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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 26, 2024 | 7:08 PM IST
Zole-DSR Capsule is used to treat symptoms of acid reflux due to hyperacidity, stomach ulcer (Peptic ulcer disease), and Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour). Besides this, it is used short-term to treat gastroesophageal reflux disease (GERD) symptoms. It contains Rabeprazole and Domperidone, which helps reduce stomach acid and increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ). In adults, it may cause common side effects such as headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and arthralgia (joint pain). In the case of children, it may cause side effects such as upper respiratory tract infections, headache, fever, diarrhoea, vomiting, rash, and abdominal pain.
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Manufacturer/Marketer :

Iifa Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Zole-DSR Capsule

Zole-DSR Capsule is used to treat symptoms of acid reflux due to hyperacidity, stomach ulcer (Peptic ulcer disease), and Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour). Besides this, it is used short-term to treat gastroesophageal reflux disease (GERD) symptoms. GERD is a condition in which the sphincter (valve) located at the uppermost part of the stomach gets irritated and damaged due to excessive stomach acid production. As a result, the stomach acid and juice flow back into the food pipe, leading to stomach upset and heartburn. Heartburn is the post-effect of acid reflux with a burning-like feeling that rises from the stomach towards the neck.

Zole-DSR Capsule contains two medicines, namely Rabeprazole and Domperidone. Rabeprazole is a proton pump inhibitor that helps reduce stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This gastric proton pump lies in the cells of the stomach wall. It is responsible for releasing gastric acid secretion and damaging tissues in the food pipe, stomach, and duodenum (uppermost part of the small intestine). On the other hand, Domperidone is a prokinetic agent that increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).

It is better to take Zole-DSR Capsule an hour before a meal or without a meal for its best results. Zole-DSR Capsule should be swallowed whole with a glass of water. Do not chew, crush, or break it. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early, your symptoms may come back, and your condition may worsen. An adult taking Zole-DSR Capsule might have common side effects like headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and arthralgia (joint pain). In the case of children taking Zole-DSR Capsule , they might report upper respiratory tract infections (URI), headache, fever, diarrhoea, vomiting, rash, and abdominal pain. These side effects are temporary and may resolve after some time; however, if this persists, contact the doctor.

You can increase the efficacy of Zole-DSR Capsule by taking a small meal or snacks frequently. Avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes). Tell your doctor if you have stomach or intestinal cancer, liver problems, are allergic to Zole-DSR Capsule or will have an endoscopy in the future. Prolonged intake of Zole-DSR Capsule may cause a deficiency of Vitamin B-12 and low levels of calcium, magnesium, and Vitamin D, leading to osteoporosis (brittle or weak bones).

Uses of Zole-DSR Capsule

Treatment of Gastro-Esophagal Reflux Disease (GERD), Acid reflux, Heartburn, Peptic ulcer, stomach ulcers, and Dyspepsia (stomach discomfort due to indigestion).

Medicinal Benefits

Zole-DSR Capsule helps in reducing the excess amount of stomach. In turn, it prevents the formation of an ulcer in the upper part of the intestine (duodenal ulcer), gastro-esophagal reflux disease (GERD) with or without ulcer and Zollinger-Ellison Syndrome, in which the stomach makes exceptionally high amounts of acid. Besides, the Zole-DSR Capsule also treats symptoms of nausea and vomiting in adults and children over 12 years of age (with at least 35 kg or more).

Side Effects of Zole-DSR Capsule

  • Rash

  • Brittle bones

  • Low vitamin B-12

  • Loss of libido (sexual desire)

  • Cough

  • Sore throat

  • Runny nose

  • Flatulence (gas formation)

  • Back pain

  • Weakness or loss of strength

  • Sleeplessness

  • Headache

  • Dizziness

  • Benign polyps in the stomach

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

You should avoid taking Zole-DSR Capsule if you are allergic to Zole-DSR Capsule or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, are pregnant or planning for pregnancy, and breastfeeding mothers. Zole-DSR Capsule may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of Zole-DSR Capsule may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its tissues), Vitamin B-12, and magnesium deficiency. Intake of Zole-DSR Capsule may mask the symptom of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool), immediately consult the doctor. Tell your doctor that you are using before having a specific blood test known as Chromogranin A.

Therapeutic Class

GASTROINTESTINAL AGENTS

Diet & Lifestyle Advise

  • Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.

  • Avoid taking alcohol and smoking cigarette. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing stomach acid backflow into the food pipe.

  • Avoid regular sitting continuously, as it can increase stomach acid production. Try to take a break of 5 minutes in 1 hour by brisk walking or stretching.

  • Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows, instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.

  • Include high fibre containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B 12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess stomach acid production. Cranberry juice can be beneficial in the peptic ulcer and H Pylori infection.

Habit Forming

No

What if I have taken an overdose of Zole-DSR Capsule

Do not take more than the prescribed dose of Zole-DSR Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.
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Alcohol

Caution

Drinking alcohol with Zole-DSR Capsule may cause dehydration and elevate the level of stomach acid, thereby decreasing its efficiency. So try to avoid, limit alcohol or contact a doctor before intake of Zole-DSR Capsule .

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Pregnancy

Caution

It is not known whether the Zole-DSR Capsule affects the baby or not. So, contact a doctor before intake of Zole-DSR Capsule . Your doctor will weigh the benefits and potential risks before prescribing them.

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Breast Feeding

Caution

Domperidone present in Zole-DSR Capsule passes into the breast milk. However, no evidence of risk has been reported. Please consult your doctor before intake of Zole-DSR Capsule . Your doctor will weigh the benefits and potential risks before prescribing them.

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Driving

Caution

In some cases, Zole-DSR Capsule may cause dizziness, sleepy, or blur vision. If you observe these symptoms do not drive or operate heavy machinery until you feel better.

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Liver

Caution

If u have or had history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Caution

If u have or had history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

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Children

Caution

Zole-DSR Capsule is not recommended for use in children due to a lack of data on safety and efficacy. Please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

SHIVASHAKTI INDUSTRIEST,J.R BORIGHA MARG,-400011,Mumbai,Maharashtra,INDIA
Other Info - ZOL0168

Author Details

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FAQs

Zole-DSR Capsule is used to treat Gastro-Esophagal Reflux Disease (GERD), acid reflux, heartburn, peptic ulcer, stomach ulcers, and dyspepsia (stomach discomfort due to indigestion). It works by blocking the actions of the gastric proton pump, increasing the motility of the upper gastrointestinal tract and blocking the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).
No. Zole-DSR Capsule prevents excess production of stomach acid causing acid reflux and heartburn. If blood is coming in your stool or mucous immediately contact the doctor.
Yes, Zole-DSR Capsule can cause dry mouth and it is due to domperidone. In case you fell excessive thirsty, please increase your fluid intake and do frequent mouth rinses.
Diarrhoea might be a side-effect of Zole-DSR Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or any other discomfort.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting on a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Zole-DSR Capsule is contraindicated in patients with a known hypersensitivity to domperidone or rabeprazole or any other inactive ingredients of Zole-DSR Capsule . Zole-DSR Capsule should be used with caution in patients with underlying liver or kidney disease.
Store Zole-DSR Capsule at room temperature in a cool and dry place protected from light. Keep it out of reach of children.
Yes, Zole-DSR Capsule is safe for most of the patients. However, in some patients it may cause common side effects such as stomach pain, diarrhea, flatulence (gas), dryness in mouth, headache, dizziness, and other uncommon and rare side effects. If these side effects persist or worsen, please consult your doctor.
It is preferable to take Zole-DSR Capsule on an empty stomach or before the first meal of the day.
Yes, Zole-DSR Capsule may increase the risk of developing irregular heartbeat (serious arrhythmias). Although, it is a serious side effect, it is extremely unlikely to occur. Patients aged above 60 years are at higher risk.

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