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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
ZIVAST AM TABLET is used to treat high blood pressure, chest pain, and clogged arteries. It contains Atorvastatin and Amlodipine which work by blocking liver enzymes, causing the liver to make less cholesterol and relaxing blood vessels, thereby improving blood flow and lowering the blood pressure. This medicine may sometimes cause side effects such as nausea, stomach pain, headache, sleepiness, constipation, muscle pain and tiredness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Whats That

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Synonym :

ATORVASTATIN+S AMLODIPINE

Manufacturer/Marketer :

FDC Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About ZIVAST AM TABLET

ZIVAST AM TABLET is a combination of cholesterol-lowering agent and anti-hypertensive agent, primarily used to treat high blood pressure, chest pain (angina) and coronary artery disease (clogged arteries). It lower raised bad cholesterol levels (low-density lipoprotein - LDL), triglycerides (TG) and increases good cholesterol levels (high-density lipoprotein - HDL) in the body. A heart attack occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).

ZIVAST AM TABLET is composed of two medicines, namely: Atorvastatin and Amlodipine. Atorvastatin belongs to the class of drugs known as statins or HMG-CoA reductase inhibitor. It works by blocking liver enzymes, causing the liver to make less cholesterol. Amlodipine belongs to the class of 'calcium channel blockers' and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain) and other conditions caused by coronary artery disease. It relaxes blood vessels, so that blood passes through them easily, thereby lowers the blood pressure. Thus, ZIVAST AM TABLET lowers the risk of stroke and heart attack in people with diabetes and coronary heart disease with raised cholesterol level. 

Your doctor will advise you how often you take ZIVAST AM TABLET based on your medical condition. The common side effects of ZIVAST AM TABLET include nausea, stomach pain, headache, sleepiness, ankle swelling, flushing (warm sensation in the face, ears, neck and trunk), palpitations (pounding heartbeat), constipation, muscle pain and tiredness. These side effects do not occur in everyone using ZIVAST AM TABLET and may vary individually. If you notice any side effects that are not manageable, it is advised to consult your doctor.

Try not to stop taking this medicine of your own. Stopping ZIVAST AM TABLET may worsen your condition and increase the risk of a future heart attack. Let your doctor know if are sensitive to ZIVAST AM TABLET and have any kidney/liver diseases and heart problems like aortic/mitral stenosis (reduced blood flow from left atrium to the left ventricle due to narrowing of the mitral valve). ZIVAST AM TABLET is not recommended for use in pregnancy and breastfeeding. ZIVAST AM TABLET may cause dizziness, hence it is advised to drive only when you are mentally alert.

Uses of ZIVAST AM TABLET

Treatment of High blood pressure (hypertension), Chest pain (angina), and Coronary artery disease (clogged arteries).

Directions for Use

Swallow ZIVAST AM TABLET as a whole with water; do not crush, break or chew it.

Medicinal Benefits

ZIVAST AM TABLET is used to treat myocardial infarction (heart attack), stroke or coronary artery disease. It also lowers abnormally elevated bad cholesterol or fat levels and raises good cholesterol levels in the body. ZIVAST AM TABLET is composed of Atorvastatin and Amlodipine. Atorvastatin is a cholesterol-lowering agent and HMG-CoA reductase inhibitor. It works by blocking liver enzymes, causing the liver to make less cholesterol. Atorvastatin reduces the risk of coronary events, such as heart attack, stroke and angina (chest pain). Amlodipine is a calcium channel blocker that relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. It treats high blood pressure, Prinzmetal's or variant angina (chest pain) and coronary artery disease conditions. Amlodipine also improves blood supply to the heart muscle to receive more oxygen and thus preventing chest pain. ZIVAST AM TABLET helps lower cholesterol and blood pressure, thereby preventing a heart attack, stroke and other peripheral vascular diseases. 

How ZIVAST AM TABLET Works

ZIVAST AM TABLET is composed of two medicines, namely: Atorvastatin and Amlodipine. Atorvastatin belongs to the class of drugs known as statins or HMG-CoA reductase inhibitor. It works by blocking liver enzymes, causing the liver to make less cholesterol. Amlodipine belongs to the class of 'calcium channel blockers' and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain) and other conditions caused by coronary artery disease. It relaxes blood vessels, so that blood passes through them easily, thereby lowers the blood pressure. Thus, ZIVAST AM TABLET lowers the risk of stroke and heart attack in people with diabetes and coronary heart disease with raised cholesterol level.

Storage

Store in a cool and dry place away from sunlight

Side Effects of ZIVAST AM TABLET

  • Nausea
  • Stomach pain
  • Headache
  • Sleepiness
  • Ankle swelling
  • Flushing (warm sensation in the face, ears, neck and trunk)
  • Palpitations (pounding heartbeat)
  • Constipation
  • Muscle pain
  • Tiredness

What if I have taken an overdose of ZIVAST AM TABLET

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

It is important to tell your doctor if you have any kidney/liver diseases, muscle pain, diabetes, thyroid disorders, alcohol use, and heart problems (aortic/mitral stenosis) before using ZIVAST AM TABLET. The patient should inform the doctor if he/she is taking ZIVAST AM TABLET before any surgery is scheduled or any new medicine is taken. ZIVAST AM TABLET can have harmful effects on the baby when a pregnant mother uses it. Also, ZIVAST AM TABLET can pass into the breast milk and may affect the breastfed infants. ZIVAST AM TABLET is contraindicated during pregnancy and breastfeeding. ZIVAST AM TABLET may cause dizziness, headaches, nausea or tiredness that can affect your ability to drive; hence drive or operate machinery only when you are alert. Avoid alcohol intake while using ZIVAST AM TABLET since it may lead to increased blood pressure and further worsening of side effects. ZIVAST AM TABLET should be used in children only under a doctor's supervision. 

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
AtorvastatinPosaconazole
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with ZIVAST AM TABLET:
Using ZIVAST AM TABLET together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking ZIVAST AM TABLET with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
AtorvastatinPosaconazole
Critical
How does the drug interact with ZIVAST AM TABLET:
Taking ZIVAST AM TABLET with Posaconazole can increase the blood levels of ZIVAST AM TABLET. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole with ZIVAST AM TABLET, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AmlodipineTizanidine
Severe
How does the drug interact with ZIVAST AM TABLET:
Co-administration of Tizanidine and ZIVAST AM TABLET can increase the risk or severity of developing side effects like low blood pressure.

How to manage the interaction:
Although co-administration of ZIVAST AM TABLET with tizanidine can result in an interaction, it can be taken when a doctor has advised it. However, if you experience headache, dizziness, palpitations, or irregular heart rate while taking these drugs, contact the doctor immediately. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not discontinue any medications without consulting the doctor.
AmlodipinePrimidone
Severe
How does the drug interact with ZIVAST AM TABLET:
Using ZIVAST AM TABLET and primidone together may lower ZIVAST AM TABLET blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of ZIVAST AM TABLET with primidone can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineNitisinone
Severe
How does the drug interact with ZIVAST AM TABLET:
Coadministration of ZIVAST AM TABLET and Nitisinone may increase the blood levels and effects of Nitisinone.

How to manage the interaction:
Taking Nitisinone with ZIVAST AM TABLET together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms or if you feel unwell after taking your medication, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineMitotane
Severe
How does the drug interact with ZIVAST AM TABLET:
Using ZIVAST AM TABLET and mitotane together may drastically lower ZIVAST AM TABLET blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of ZIVAST AM TABLET with mitotane can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineIdelalisib
Severe
How does the drug interact with ZIVAST AM TABLET:
Coadministration of ZIVAST AM TABLET and Idelalisib may raise ZIVAST AM TABLET levels in the blood this may lead to serious side effects (irregular heart rhythm, fluid retention, swelling, heart failure, and abnormally low blood pressure).

How to manage the interaction:
Although taking ZIVAST AM TABLET with idelalisib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness or fainting, sudden, unexplained weight gain, swelling of the hands, ankles, or feet, chest discomfort, or trouble breathing while taking these drugs, consult the doctor. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not stop using any medications without a doctor's advice.
AmlodipineDolasetron
Severe
How does the drug interact with ZIVAST AM TABLET:
Using dolasetron together with ZIVAST AM TABLET can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between ZIVAST AM TABLET and Dolasetron, but it can be taken if prescribed by a doctor. If you have any of these symptoms, like feeling dizzy, lightheaded, or your heart beating irregularly, it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineRifampicin
Severe
How does the drug interact with ZIVAST AM TABLET:
Coadministration of ZIVAST AM TABLET and rifampicin together may lower ZIVAST AM TABLET blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between ZIVAST AM TABLET and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AmlodipineRifapentine
Severe
How does the drug interact with ZIVAST AM TABLET:
Coadministration of ZIVAST AM TABLET and Rifapentine may significantly reduce the blood levels of ZIVAST AM TABLET, which may make the medication less effective.

How to manage the interaction:
There may be a possibility of interaction between ZIVAST AM TABLET and Rifapentine, but it can be taken if prescribed by a doctor. If you have any symptoms, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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AMLODIPINE-5MG+ATORVASTATIN-10MGFruit juices
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+ATORVASTATIN-10MGFruit juices
Moderate
Common Foods to Avoid:
Grapefruit Juice, Pineapple Juice, Pomegranate Juice, Noni Juice, Orange Juice, Cranberry Juice

How to manage the interaction:
Consumption of grape juice can increase the blood levels of atorvastatin and causes side effects. Avoid taking grape juice with atorvastatin as it can lead to an interaction, You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, Do not stop using any medications without a doctor's advice.

Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take ZIVAST AM TABLET.
  • Low cholesterol diet and regular exercise regime are found to complement treatment with ZIVAST AM TABLET effectively. 
  • Keep your cholesterol and triglyceride levels under control.
  • Eat at regular intervals and maintain a healthy diet that includes fresh fruits, vegetables.
  • High-fat meal should be avoided as it may further increase the risk of heart attack and instead eat heart-healthy foods.
  • Limit alcohol intake since it raises blood pressure and increases the risk of heart diseases.
  • Keep a check on your weight and exercise regularly to keep your heart healthy.
  • Your doctor also guides you on noticing and managing the early symptoms of detecting heart diseases. 

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

ZIVAST AM TABLET Substitute

Substitutes safety advice
  • Amat Tablet 10's

    50.60per tablet
  • Genericart Amlodipine+Atorvastatin 5mg/10mg Tablet

    6.30per tablet
  • Atodipin 5 mg/10 mg Tablet

    6.24per tablet
  • Ctor AM 5 mg/10 mg Tablet

    7.11per tablet
  • Alip AM 5mg/10mg Tablet

    7.20per tablet
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Alcohol

Unsafe

It is unsafe to consume alcohol since it may worsen the side effects like dizziness and increases blood pressure.

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Pregnancy

Unsafe

ZIVAST AM TABLET is contraindicated and is unsafe to use during pregnancy since it has harmful effects on the foetus. If the patient becomes pregnant while using ZIVAST AM TABLET, please discontinue immediately, and you should be aware of the potential risks to the foetus. Please consult your doctor if you are planning to conceive or already pregnant before starting ZIVAST AM TABLET.

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Breast Feeding

Unsafe

ZIVAST AM TABLET is contraindicated and not recommended for use if you are lactating, since it passes through the breast milk and can affect nursing infants. Please consult your doctor before starting ZIVAST AM TABLET.

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Driving

Caution

ZIVAST AM TABLET may cause dizziness, headaches, nausea or tiredness that can affect your ability to drive. Do not drive or operate machinery if you experience such symptoms. Please seek medical attention if these symptoms persist longer.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing ZIVAST AM TABLET.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing ZIVAST AM TABLET.

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Children

Caution

Usage and dosing of ZIVAST AM TABLET in children are to be determined by the doctor. The doctor decides the dosing schedule based on the child's age and weight.

FAQs

ZIVAST AM TABLET is used to treat high blood pressure, chest pain (angina) and coronary artery disease (clogged arteries).
ZIVAST AM TABLET lowers the bad cholesterol levels and increases good cholesterol levels in the blood, preventing fat accumulation in blood vessels. It also decreases the blood pressure by widening the blood vessels and thus pumping blood to the heart. Thereby, ZIVAST AM TABLET helps treat high blood pressure, stroke, chest pain (angina) and coronary artery disease (clogged arteries).
Let your doctor know if you have any kidney/liver diseases, muscle pain, diabetes, thyroid disorders, alcohol use and heart problems (aortic/mitral stenosis) before taking ZIVAST AM TABLET. Also please inform your doctor if you have any medical issues before commencing ZIVAST AM TABLET.
ZIVAST AM TABLET can cause dizziness as one of its side effects. Please consult your doctor if you feel dizzy for a longer time. To reduce dizziness and light-headedness symptoms, it is advised to get up slowly when you rise from a sitting or lying position. Avoid driving or operating machinery during episodes of dizziness.
It is advised to limit or avoid the intake of foods high in fat or cholesterol while using ZIVAST AM TABLET. This kind of foods may decrease the efficacy of ZIVAST AM TABLET. Also please avoid taking grapefruit and its products since it may produce unwanted effects with ZIVAST AM TABLET. Red yeast rice products are also not recommended while using ZIVAST AM TABLET since they may increase muscle and liver problems.
Nitroglycerine is a blood pressure-lowering agent so if you are using this, let your doctor know about this before using ZIVAST AM TABLET.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
Stopping ZIVAST AM TABLET abruptly can lead to adverse effects, such as increased heart rate, or worsening of your condition. Consult your doctor before stopping the medication.
Inform your doctor if you are due to undergo any surgery or dental procedure. Regular ECG checks and monitoring cholesterol levels (HDL, LDL) through blood tests are also recommended. Avoid alcohol intake while using ZIVAST AM TABLET since it may lead to increased blood pressure and further worsening of side effects.
Before taking ZIVAST AM TABLET, inform your doctor about your medical history, allergies, and current medications. Let the doctor know if you are pregnant or breastfeeding.
The common side effects of ZIVAST AM TABLET include nausea, stomach pain, headache, sleepiness, ankle swelling, flushing (warm sensation in the face, ears, neck, and trunk), palpitations (pounding heartbeat), constipation, muscle pain, and tiredness. These side effects do not occur in everyone using ZIVAST AM TABLET and may vary individually. If you notice any side effects that are not manageable, it is advised to consult your doctor.

Country of origin

India

Manufacturer/Marketer address

FDC LIMITED, B-8, MIDC Area, Waluj - 431 136, Dist. Aurangabad, Maharashtra
Other Info - ZIV0016

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