ZIGMA CR 400MG TABLET belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy (fits) and trigeminal neuralgia (pain in the face's nerves). Epilepsy is a neurological disorder in which there is a sudden rush of electric impulses (electric activity) in the brain. As a result, the brain's electrical rhythms become imbalanced, resulting in recurrent episodes of seizures or fits. Trigeminal neuralgia is a condition which affects the trigeminal nerve that carries sensations from the face to the brain. 

ZIGMA CR 400MG TABLET contains 'Carbamazepine' that reduces the electrical impulses and subsequent firing of the nerve impulses that cause fits. Thus, ZIGMA CR 400MG TABLET decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. 

You are advised to take ZIGMA CR 400MG TABLET for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, tiredness, uncontrolled movements, nausea, headache, changes in liver enzymes or low white blood cells count, and minor skin reactions. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

To treat your condition effectually, continue taking ZIGMA CR 400MG TABLET for as long as your doctor has prescribed. Please do not stop taking ZIGMA CR 400MG TABLET without consulting your doctor to avoid worsening of seizures. Do not take ZIGMA CR 400MG TABLET if you are pregnant or planning for pregnancy unless prescribed by the doctor as it could lead to serious congenital disabilities. It is safe to take ZIGMA CR 400MG TABLET while breastfeeding; however, consult your doctor immediately if you think that the baby is having side-effects like excessive sleepiness, skin reactions or yellowing of skin or eyes. ZIGMA CR 400MG TABLET causes drowsiness and dizziness, so drive only if you are alert. ZIGMA CR 400MG TABLET should not be given to children unless prescribed. Avoid consuming alcohol along with ZIGMA CR 400MG TABLET as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

ZIGMA CR 400MG TABLET belongs to a group of medicines called anti-convulsants or anti-epileptics used to treat epilepsy and trigeminal neuralgia (face nerve pain). ZIGMA CR 400MG TABLET works by reducing the electrical impulses and subsequent firing of the nerve impulses that cause fits. ZIGMA CR 400MG TABLET decreases the excessive and abnormal nerve activity in the brain, thereby helping in controlling seizures. ZIGMA CR 400MG TABLET is also used to relieve nerve pain associated with trigeminal neuralgia. People with glossopharyngeal neuralgia may also experience benefit with ZIGMA CR 400MG TABLET. ZIGMA CR 400MG TABLET is not associated with any psychological or physical dependence, and there is no potential for abuse.

• Dizziness
• Tiredness
• Uncontrolled movements
• Nausea
• Headache
• Changes in liver enzymes
• Low white blood cells count
• Minor skin reactions

Do not take ZIGMA CR 400MG TABLET if you are allergic to 'Carbamezapine' or any of its contents, have serious heart problems, blood illnesses, bone marrow problems, hypothyroidism, glaucoma, urinary retention, osteoporosis or taking anti-depressants called monoamine oxidase inhibitors (MAO's) within the last 14 days or taking herbal preparations containing St. John's wort as an antidepressant. Inform the doctor if you have low sodium levels in the blood or take medicines that could lower the blood's sodium levels, or using hormonal contraceptives. Do not stop taking ZIGMA CR 400MG TABLET without consulting your doctor to avoid worsening of seizures episodes. Do not take ZIGMA CR 400MG TABLET if you are pregnant unless prescribed by the doctor as ZIGMA CR 400MG TABLET might cause serious congenital disabilities. It is safe to take ZIGMA CR 400MG TABLET while breastfeeding; however, consult your doctor immediately if you think that the baby is having side-effects like excessive sleepiness, skin reactions or yellowing of skin or eyes. ZIGMA CR 400MG TABLET causes drowsiness and dizziness, so drive only if you are alert. ZIGMA CR 400MG TABLET should not be given to people less than 18 years of age until and unless prescribed by the doctor. Avoid consuming alcohol along with ZIGMA CR 400MG TABLET as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies or mood swings. 

Drug-Drug Interactions: ZIGMA CR 400MG TABLET may have interaction with antipsychotic (aripiprazole, quetiapine), anti-anxiety (alprazolam), anti-depressant (amitriptyline, duloxetine, sertraline, fluoxetine), antibiotics (erythromycin), pain killer (codeine, oxycodone, acetaminophen, tramadol), anti-convulsant (gabapentin, lamotrigine, pregabalin, phenytoin, topiramate), anti-thyroid (levothyroxine), antipsychotic (lithium), insomnia (melatonin), anti-coagulant (warfarin), antihistamine (diphenhydramine), and vitamin (cholecalciferol).

Drug-Food Interactions: Avoid consumption of alcohol while taking ZIGMA CR 400MG TABLET as it might cause increased dizziness and sleepiness. Avoid consuming grapefruit juice while taking ZIGMA CR 400MG TABLET. Herbal preparations containing St. John's wort should be avoided while taking ZIGMA CR 400MG TABLET.

Drug-Disease Interactions: ZIGMA CR 400MG TABLET may have interactions with disease conditions such as depression, liver disease, kidney dysfunction, suicidal tendency, irregular heartbeat, thyroid dysfunction, hyponatremia (low levels of sodium in the blood), blood disorders, anticholinergic effects, fructose intolerance, and psychosis.

• ARIPIPRAZOLE
• QUETIAPINE
• ALPRAZOLAM
• AMITRIPTYLINE
• DULOXETINE
• SERTRALINE
• FLUOXETINE
• ERYTHROMYCIN
• CODEINE
• OXYCODONE
• ACETAMINOPHEN
• TRAMADOL
• GABAPENTIN
• LAMOTRIGINE
• PREGABALIN
• PHENYTOIN
• TOPIRAMATE
• LEVOTHYROXINE SODIUM
• LITHIUM
• MELATONIN
• WARFARIN
• DIPHENHYDRAMINE
• CHOLECALCIFEROL

• A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.

• Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.

• Rest well, get plenty of sleep.

• Avoid smoking and alcohol consumption.

• Exercise, meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.

• Prepare your living area; small changes may reduce the risk of physical injury during a seizure.

• Install an alarm or emergency device to get assistance during a seizure attack.

• Regular monitoring of sodium levels while taking ZIGMA CR 400MG TABLET is advised to prevent hyponatremia.

• Prolonged intake of ZIGMA CR 400MG TABLET can cause severe skin reactions called Stevens Johnsons syndrome (SJS) and toxic epidermal necrolysis (TEN). So in case you have any skin blister or rash immediately contact a doctor. 

• ZIGMA CR 400MG TABLET may cause low blood cell count, so if you have any red or purple spots on the body, let your doctor know about this. 

Epilepsy/Seizures: Seizures, also known as fits or convulsions, is a single occurrence of abnormal electrical activity in the brain, whereas epilepsy is a chronic neurological disorder characterised by recurrent seizures. The possible causes of epilepsy include traumatic brain injury, scarring on the brain after a brain injury, high fever, stroke, vascular diseases, lack of oxygen to the brain, brain tumours, and genetic disorders. Symptoms include mood changes, anxiousness, nausea, dizziness, weakness, headache, muscle jerking, spasms, loss of balance, teeth clenching, rapid blinking or eye movements, biting the tongue, confusion, and loss of consciousness.

Trigeminal neuralgia: It is a condition affecting the trigeminal nerve in the face that causes painful sensations similar to electric shock on one side of the face. Symptoms include mild to severe facial pain often triggered by speaking, chewing, or brushing the teeth.