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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Zestril 5 mg Tablet is used to treat high blood pressure (hypertension) and reduce the risk of having a heart attack, stroke, or heart failure. It contains Lisinopril, which works by lowering the body's production of substances that could increase blood pressure. It relaxes and widens the blood vessels, making it easier for the heart to pump blood to all parts of the body. Thus, it lowers the raised blood pressure and reduces the risk of heart failure, heart attack or stroke. Sometimes, you may experience common side effects like headache, dizziness, fatigue, and cough. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LISINOPRIL-5MG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Zestril 5 mg Tablet

Zestril 5 mg Tablet is used to treat high blood pressure (hypertension) and reduce the risk of having a heart attack, stroke, or heart failure. High blood pressure is a chronic condition in which the pressure in the blood vessels is high. The blood exerts high pressure on blood vessel walls (arteries), leading to hypertension. Heart failure can occur when your heart cannot pump the blood sufficiently required for the body's remaining. A heart attack or stroke is the blockage of blood flow to the heart muscle. The blockade usually occurs due to fat/cholesterol build-up in the coronary artery (which supplies blood to the heart). 

Zestril 5 mg Tablet contains lisinopril, which works by lowering the body’s production of substances that could increase blood pressure. Zestril 5 mg Tablet relaxes and widens the blood vessels, making it easier for the heart to pump blood to all parts of the body, lowering the raised blood pressure and reducing the risk of heart failure, heart attack or stroke.

Take Zestril 5 mg Tablet with or without food. Do not chew, crush, or break the tablet; swallow it as a whole with a glass of water. Take Zestril 5 mg Tablet at the same time every day. Sometimes, you may experience common side effects like headache, dizziness, fatigue, and cough. Most of these side effects do not require medical attention and resolve gradually over time. Talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Zestril 5 mg Tablet for as long as your doctor has prescribed it. Try not to stop taking it on your own as it may cause a sudden increase the blood pressure, chest pain or heart attack. Regular monitoring of blood pressure, electrolyte levels and kidney functioning is advised while taking Zestril 5 mg Tablet . It would help to consume low table salt (sodium chloride) and a low-fat diet while taking Zestril 5 mg Tablet . Avoid taking Zestril 5 mg Tablet if you are pregnant or breastfeeding. Talk to your doctor. They may prescribe you alternate medicine. Zestril 5 mg Tablet is not recommended for children below 18 years of age as efficacy and safety have not been established.

Uses of Zestril 5 mg Tablet

Treatment of Hypertension (high blood pressure), Prevention of heart attack, stroke and heart failure.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Zestril 5 mg Tablet relaxes and widens the blood vessels, making it easier for the heart to pump blood to all body parts. This helps lower blood pressure and the risk of a heart attack or stroke. Zestril 5 mg Tablet helps reduce standing and lying down blood pressure without any orthostatic effect (a sudden decrease in blood pressure might occur when a person stands up suddenly). However, when dehydrated, Zestril 5 mg Tablet may show an orthostatic effect. Continued usage of Zestril 5 mg Tablet reduces the severity of heart failure, hospitalization rate and symptoms such as weakness and shortness of breath. Zestril 5 mg Tablet is used alone or in combination with other medicines to treat high blood pressure.

How Zestril 5 mg Tablet Works

Zestril 5 mg Tablet contains lisinopril, which works by lowering the body's production of substances that could increase blood pressure. Zestril 5 mg Tablet relaxes and widens the blood vessels, making it easier for the heart to pump blood to all parts of the body, lowering the raised blood pressure and reducing the risk of heart failure, heart attack or stroke.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Zestril 5 mg Tablet

  • Headache

  • Nausea

  • Dizziness 

  • Weakness 

  • Hypotension (low blood pressure)

  • Sinusitis (inflammation of the sinus) 

  • Shortness of breath 

  • Stomach pain 

  • Diarrhea

  • Indigestion

  • Skin rash

  • Chest pain

  • Muscle pain

  • Hyperkalemia (increased levels of potassium in the blood)

  • A dry cough that does not go away

  • Kidney problems (shown in a blood test)

What if I have taken an overdose of Zestril 5 mg Tablet

Do not take more than the prescribed dose of Zestril 5 mg Tablet as it may cause overdose. The symptoms of overdose include lightheadedness and fainting. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Zestril 5 mg Tablet if you are allergic to Zestril 5 mg Tablet or any of its contents. Talk to your doctor if you have heart, kidney or liver problems. Zestril 5 mg Tablet may sometimes cause lower blood pressure than normal, especially in dehydrated people who take diuretics (medicines to treat oedema) and low sodium levels. Regularly check your blood pressure levels to avoid any risks. Avoid taking Zestril 5 mg Tablet if you are pregnant or breastfeeding. Talk to your doctor. They may prescribe you alternate medicine. Zestril 5 mg Tablet is not recommended for children below 18 years of age as efficacy and safety have not been established. Inform your doctor about your medications and your health condition to rule out any unpleasant side effects. Consult your doctor if you have lost a lot of body fluids through vomiting, diarrhoea, or sweating more than normal or if you are taking low water tablets to treat oedema (diuretics), or if you undergo dialysis. Stop taking Zestril 5 mg Tablet one day before receiving an anaesthetic to undergo any surgery or dental procedure. Inform your doctor that you are taking Zestril 5 mg Tablet . Regular monitoring of blood pressure, electrolyte levels and kidney functioning is advised while taking Zestril 5 mg Tablet .

Drug-Drug Interactions

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LisinoprilAliskiren
Critical
LisinoprilIrbesartan
Severe

Drug-Drug Interactions

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LisinoprilAliskiren
Critical
How does the drug interact with Zestril 5 mg Tablet 15's:
Combining Aliskiren with Zestril 5 mg Tablet 15's can increase the potassium levels in the blood.

How to manage the interaction:
Although taking Aliskiren and Zestril 5 mg Tablet 15's together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience symptoms including weakness, tiredness, confusion, numbness or tingling, and irregular heartbeats. Do not discontinue any medications without a doctor's advice.
LisinoprilIrbesartan
Severe
How does the drug interact with Zestril 5 mg Tablet 15's:
Taking Irbesartan with Zestril 5 mg Tablet 15's may increase potassium levels in the blood.

How to manage the interaction:
Although taking Irbesartan with Zestril 5 mg Tablet 15's together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
LisinoprilValsartan
Severe
How does the drug interact with Zestril 5 mg Tablet 15's:
Coadministration of Zestril 5 mg Tablet 15's and Valsartan may increase the risk of side effects (low blood pressure, kidney function impairment, hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Zestril 5 mg Tablet 15's together with Valsartan may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
LisinoprilSpironolactone
Severe
How does the drug interact with Zestril 5 mg Tablet 15's:
Using Zestril 5 mg Tablet 15's together with spironolactone may cause hyperkalemia (increase the levels of potassium in your blood).

How to manage the interaction:
Taking Zestril 5 mg Tablet 15's with Spironolactone is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feeling of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. Do not stop taking any medication without doctor's advise.
LisinoprilTeriflunomide
Severe
How does the drug interact with Zestril 5 mg Tablet 15's:
Taking Teriflunomide with Zestril 5 mg Tablet 15's affects the liver and may increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Zestril 5 mg Tablet 15's and Teriflunomide, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor: liver problems, fever, feeling cold, joint discomfort, swelling, bruising, skin irritation, itching, not feeling hungry, tiredness, feeling sick, throwing up, stomach ache, dark urine, liver harm, or bleeding. Do not stop using any medications without a doctor's advice.
LisinoprilLeflunomide
Severe
How does the drug interact with Zestril 5 mg Tablet 15's:
Taking leflunomide with Zestril 5 mg Tablet 15's affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Taking Leflunomide with Zestril 5 mg Tablet 15's together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LisinoprilMipomersen
Severe
How does the drug interact with Zestril 5 mg Tablet 15's:
Taking Zestril 5 mg Tablet 15's with Mipomersen affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Co-administration of Zestril 5 mg Tablet 15's with Mipomersen can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LisinoprilCandesartan
Severe
How does the drug interact with Zestril 5 mg Tablet 15's:
Taking Zestril 5 mg Tablet 15's with candesartan can increase the risk of high potassium levels.

How to manage the interaction:
Taking Zestril 5 mg Tablet 15's with Candesartan together can possibly result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your blood pressure regularly. If you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
LisinoprilLomitapide
Severe
How does the drug interact with Zestril 5 mg Tablet 15's:
Taking Lomitapide with Zestril 5 mg Tablet 15's affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking Zestril 5 mg Tablet 15's and Lomitapide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LisinoprilLosartan
Severe
How does the drug interact with Zestril 5 mg Tablet 15's:
Coadministration of Losartan with Zestril 5 mg Tablet 15's can increase potassium levels.

How to manage the interaction:
Taking Losartan with Zestril 5 mg Tablet 15's together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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LISINOPRIL-5MGPotassium rich foods
Moderate

Drug-Food Interactions

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LISINOPRIL-5MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Consuming potassium rich diet when on treatment with Zestril 5 mg Tablet 15's can increase the potassium levels in the blood. Although there is a possible interaction, Zestril 5 mg Tablet 15's can be taken on doctor's advice with limiting potassium-containing food. If you experience any unusual effects like weakness, tiredness, confusion, numbness or tingling, and irregular heartbeats, consult a doctor. Do not discontinue any medication without doctor's advise.

Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet while taking Zestril 5 mg Tablet .

  • Regular exercise is also recommended to complement treatment with Zestril 5 mg Tablet .

  • Eat a diet rich in whole grains, vegetables, and fruits.

  • Avoid smoking and alcohol consumption.

  • Maintain a healthy weight with proper diet and exercise.

  • Managing stress with meditation, yoga, and massage would also help treat high blood pressure.

Habit Forming

No

Therapeutic Class

ACE INHIBITORS

Zestril 5 mg Tablet Substitute

Substitutes safety advice
  • Listril 5 Tablet 15's

    13.08per tablet
  • Lipril 5 Tablet 15's

    11.94per tablet
  • Hipril 5mg Tablets 10's

    6.21per tablet
  • Lisoril-5 Tablet 10's

    7.56per tablet
  • BIOPRIL 5MG TABLET

    4.32per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Zestril 5 mg Tablet to avoid unpleasant side-effects. Alcohol intake might interfere with the working of Zestril 5 mg Tablet . Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

It is not recommended to take Zestril 5 mg Tablet while you are pregnant. Please consult your doctor if you have any concerns regarding this, your doctor will decide whether Zestril 5 mg Tablet can be given to pregnant women or not.

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Breast Feeding

Unsafe

It is not recommended to take Zestril 5 mg Tablet while you are breastfeeding. Please consult your doctor if you have any concerns regarding this, your doctor will decide whether Zestril 5 mg Tablet can be given to breast-feeding mothers or not.

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Driving

Caution

Zestril 5 mg Tablet may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Zestril 5 mg Tablet should be used with caution in patients with liver disease. Please consult your doctor if you have any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Zestril 5 mg Tablet should be used with caution in patients with kidney disease. Please consult your doctor if you have any concerns regarding this.

bannner image

Children

Unsafe

Zestril 5 mg Tablet should not be used by children, as the efficacy and safety have not been established.

FAQs

Zestril 5 mg Tablet is used to treat high blood pressure (hypertension) and reduce the risk of having a heart attack, stroke, or heart failure.
Zestril 5 mg Tablet belongs to the group of medicines called Angiotensin Converting Enzyme (ACE) Inhibitors that works by lowering the body’s production of substances that could increase the blood pressure. Zestril 5 mg Tablet relaxes and widens the blood vessels making it easier for the heart to pump blood to all parts of the body. This helps in lowering the blood pressure and the risk of having a heart attack or stroke.
If you are diabetic you should monitor your blood glucose levels often especially in the first few weeks because Zestril 5 mg Tablet can lower glucose/sugar levels in the blood. However, please consult your doctor before taking Zestril 5 mg Tablet if you are diabetic.
Please do not stop taking Zestril 5 mg Tablet without consulting your doctor on your own as it may lead to rise in blood pressure. Continue taking Zestril 5 mg Tablet for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Zestril 5 mg Tablet .
Yes, orthostatic hypotension could be a side-effect of Zestril 5 mg Tablet especially in people who are dehydrated. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Zestril 5 mg Tablet are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.
Do not overdose on Zestril 5 mg Tablet or any medicine as it could lead to very unpleasant side-effects. Take Zestril 5 mg Tablet only as prescribed by your doctor. Overdose of Zestril 5 mg Tablet can cause increased heartbeat, dizziness, and sleepiness. Rush to your nearest doctor as early as possible if you have overdosed on Zestril 5 mg Tablet .
The most common side-effects of Zestril 5 mg Tablet are headache, nausea, dizziness, weakness, low blood pressure, inflammation of the sinus (sinusitis), shortness of breath, stomach pain, diarrhea, indigestion, skin rash, chest pain, muscle pain, and increased levels of potassium in the blood. Please consult your doctor if you experience any of these side-effects persistently.
Zestril 5 mg Tablet may cause nasal congestion due to dilation of vessels in the nasal mucosa.
Before taking Zestril 5 mg Tablet you should tell your doctor if you are allergic to Zestril 5 mg Tablet or any of its ingredients, if you have diabetes, irregular blood pressure, any problems related to heart, kidneys (if you are on dialysis), liver, or blood, such as a low white blood cell count (neutropenia or agranulocytosis) and if you have recently had diarrhea or vomiting. Let your doctor know about all the other medicines you are taking as they may affect, or be affected by Zestril 5 mg Tablet . If you are pregnant or breastfeeding or are planning to conceive, consult your doctor before taking Zestril 5 mg Tablet to avoid any harmful effects on the baby.
Zestril 5 mg Tablet should be taken at the same time every day to reduce the chances of a missed dose. As it can make you dizzy, your doctor may advise you to take your first dose before bedtime. If you do not feel dizzy after the first dose, you may take Zestril 5 mg Tablet at any time of the day.
Yes, Zestril 5 mg Tablet may make you feel dizzy or lightheaded. If you feel dizzy when you stand up, try getting up very slowly or stay seated until you feel better. To avoid fainting, lie down if you begin to feel dizzy, then sit until you feel better. Avoid driving or using tools or machines and anything requiring concentration while you are feeling dizzy or shaky.
Avoid taking excess salt in your diet and find ways to manage or reduce stress in your life. Take up a hobby, or practice meditation or yoga. Make sure that you have a sound sleep every night as this also lowers stress levels and helps to keep your blood pressure normal. Quit smoking and alcohol consumption as this helps in lowering your blood pressure and preventing heart problems. Exercise regularly and eat a balanced diet that includes fresh fruits, vegetables, whole grains, and fat-free products. If you need any further guidance, consult your doctor to get the maximum benefit of Zestril 5 mg Tablet and to keep yourself healthy.
Some people may experience dry cough, as a side effect of Zestril 5 mg Tablet , which can be persistent and may not be relieved by any medicine. Talk to your doctor if it bothers you or if you have problems falling asleep. Your doctor may advice ways of managing the cough or may recommend another medicine. Remember, do not stop taking Zestril 5 mg Tablet without first consulting your doctor as it may raise your blood pressure and increase the risk of developing a heart attack or stroke. Even if you stop taking Zestril 5 mg Tablet , the cough may take a few days to a month to resolve completely.
There is no proof that Zestril 5 mg Tablet affects either men or women’s fertility. However, if you are planning to conceive, consult your doctor first as Zestril 5 mg Tablet is not recommended in pregnancy.
Zestril 5 mg Tablet may increase blood potassium levels, especially if you have kidney problems, uncontrolled diabetes mellitus, and dehydration. Also, potassium levels may increase in patients who are using potassium salts or medicines or are over 70 years of age. Therefore, if you have any of these conditions and are using Zestril 5 mg Tablet , be cautious and get regular blood tests done to check potassium levels.

Country of origin

India

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - ZES0001

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