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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Last Updated Jan 1, 2025 | 2:48 PM IST
Zefretol 400 Tablet is used to treat epilepsy. It contains Eslicarbazepine acetate which works by decreasing abnormal activity in the brain. In some cases, this medicine may cause side effects such as dizziness, drowsiness, fatigue and visual disturbances. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Zefretol 400 Tablet

Zefretol 400 Tablet belongs to the class of medications called ‘antiepileptic drugs’ used to treat epilepsy (fits). Epilepsy is a sudden rush of electricity in the brain. In epilepsy the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. It can cause changes in your behavior, movements or feelings and levels of consciousness.

Zefretol 400 Tablet contains ‘Eslicarbazepine acetate’ which is used to treat epilepsy or seizures. It inactivates certain channels in the brain that passes electronic signals. This effect helps to decrease abnormal activity or electrical disturbance in the brain, thereby preventing epilepsy episodes. It reduces the frequency and number of seizure episodes. 

You should use this medicine exactly as prescribed by the doctor. Zefretol 400 Tablet may cause side effects such as dizziness, drowsiness, fatigue and visual disturbances. These side effects usually resolve without requiring treatment. However, if any of these side effects persist or get worse, inform your doctor immediately.

It is not recommended to take Zefretol 400 Tablet if you are allergic to its contents or other medicines used to treat epilepsy. Before taking Zefretol 400 Tablet , inform your doctor if you have heart rhythm disorder, heart failure and primary generalized seizures (seizures that involve both sides of the brain). Some people may also experience suicidal thoughts. Seek medical attention immediately in such cases.  Zefretol 400 Tablet should be used with caution in pregnant and breastfeeding women. Zefretol 400 Tablet is not recommended for children below six years of age, severe liver diseases, and severe kidney diseases. Zefretol 400 Tablet may require dose adjustments in elderly people. Do not take alcohol while using Zefretol 400 Tablet as it may increase the risk of side effects. Zefretol 400 Tablet may cause dizziness or drowsiness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of Zefretol 400 Tablet

Treatment of Epilepsy

Medicinal Benefits

Zefretol 400 Tablet contains ‘Eslicarbazepine acetate’ which is used in the treatment of epilepsy or seizures. It acts by decreasing the electrical disturbance in the brain. It can be given as monotherapy in adults who are newly diagnosed with epilepsy. It can also be used in combination with other antiepileptic drugs in children above 6 years and adults to treat partial-onset seizures (seizures that affect one part of the brain).

Side Effects of Zefretol 400 Tablet

  • Dizziness
  • Drowsiness
  • Fatigue
  • Visual disturbances

Directions for Use

Take Zefretol 400 Tablet as advised by your doctor. Swallow it as a whole with a glass of water, do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Inform your doctor immediately if you notice cognitive disturbances such as confusion, impaired coordination and memory impairment while using Zefretol 400 Tablet . The doctor may make dose adjustments based on your condition. Inform your doctor if you notice any suicidal thoughts or behaviour. Zefretol 400 Tablet may cause hyponatremia (decreased sodium levels in the blood) and cause worsening of seizures or decreased consciousness or cognitive disturbances. So, the doctor may advise you to monitor sodium levels while using Zefretol 400 Tablet . Inform your doctor about all the prescription or non-prescription medicines you are taking as some medicines may increase PR interval. The use of Zefretol 400 Tablet with these medications can worsen the health condition. If you develop a skin rash, or other skin-related problems while using Zefretol 400 Tablet , inform your doctor immediately. Please do not stop taking the medication abruptly, as it may increase seizure frequency. So, the doctor gradually decreases the dose before completely stopping the treatment. 

Therapeutic Class

ANTICONVULSANT

Drug-Drug Interactions

verifiedApollotooltip
EslicarbazepineCariprazine
Severe
EslicarbazepineButorphanol
Severe

Drug-Food Interactions

verifiedApollotooltip
ESLICARBAZEPINE ACETATE-400MGGrapefruit and Grapefruit Juice
Moderate

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
  • Have a seizure response plan, and help those around you know what to do.
  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

How Zefretol 400 Tablet Works

Zefretol 400 Tablet contains ‘Eslicarbazepine acetate’ which is used to treat epilepsy or seizures. It inactivates certain channels in the brain that passes electronic signals. This effect helps to decrease abnormal activity or electrical disturbance in the brain, thereby preventing epilepsy episodes. It reduces the frequency and number of seizure episodes.

What if I have taken an overdose of Zefretol 400 Tablet

Take Zefretol 400 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include dizziness, nausea, vomiting, sleepiness, abnormally elevated mood, numbness or tingling in the mouth, difficulty walking or with coordination, double vision, seizures that happen more often or are worse than before, weakness, headache, confusion, irritability, and muscle weakness or spasms. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
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Alcohol

Unsafe

Avoid alcohol consumption as it may increase the risk of side-effects such as dizziness or drowsiness and worsen the condition.

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Pregnancy

Caution

Zefretol 400 Tablet should be used with caution in pregnant women as it may cause harmful effects to the unborn baby.

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Breast Feeding

Caution

Zefretol 400 Tablet should be used with caution in breastfeeding mothers as it may cause harmful effects to the nursing baby.

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Driving

Caution

Zefretol 400 Tablet may cause dizziness or drowsiness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Zefretol 400 Tablet is probably safe in patients with mild to moderate liver diseases. However, in patients with severe liver diseases, Zefretol 400 Tablet is contraindicated as this medicine may worsen the health condition.

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Kidney

Caution

Zefretol 400 Tablet may require dose adjustments when used in patients with kidney diseases. However, in patients with severe kidney impairment, Zefretol 400 Tablet is contraindicated as this medicine may worsen the health condition.

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Children

Caution

Zefretol 400 Tablet is not recommended for children below 6 years of age. In children above 6 years, dose adjustment may be required based on body weight.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ZEF0050

Author Details

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FAQs

Zefretol 400 Tablet is used to treat epilepsy (fits).
Zefretol 400 Tablet contains ‘eslicarbazepine acetate’ which is used to treat epilepsy or seizures. It inactivates certain channels in the brain that passes electronic signals. This effect reduces abnormal activity or electrical disturbance in the brain, thereby reducing the number of seizure episodes.
Zefretol 400 Tablet is possibly safe when used in patients with diabetes. However, it is essential to inform your doctor that you have diabetes before taking Zefretol 400 Tablet to avoid unwanted effects.
The common side-effects of Zefretol 400 Tablet are dizziness, drowsiness, fatigue and visual disturbances. These side-effects usually resolve without requiring treatment. However, if any of these side-effects persist or get worse, inform your doctor immediately.
Zefretol 400 Tablet should not be used in patients with heart rhythm disorders, other heart diseases, heart failure or heart attack, severe liver or kidney diseases and primary generalized seizures (seizures that involve both sides of the brain).
Zefretol 400 Tablet may alter levels of liver enzymes and electrolyte levels, so inform your doctor that you are taking Zefretol 400 Tablet before undergoing any laboratory tests.
Zefretol 400 Tablet may rarely cause change in behavior or depression and increase chance of suicidal thoughts, inform your doctor immediately if you face any of these symptoms.
No, you cannot stop taking Zefretol 400 Tablet suddenly even if you feel better as it can raise the risk of seizures. Take Zefretol 400 Tablet for as long as it is advised by your doctor. Your dose may be reduced gradually by your doctor if he/she decides to discontinue it. If you experience any difficulty while taking Zefretol 400 Tablet , please consult your doctor.
Patients with kidney disease may need dose adjustments of Zefretol 400 Tablet but it is not recommended for those with severe kidney impairment as it may worsen their condition. However, consult a doctor before use. Do not self-medicate.
Zefretol 400 Tablet affects the liver. Zefretol 400 Tablet is probably safe in patients with mild to moderate liver problems. However, in patients with severe liver problems, Zefretol 400 Tablet is contraindicated as it may worsen the condition. Thus, if you have liver problem, your doctor may recommend regular liver function tests.
Signs of suicidal thoughts include pulling away from people, mood swings, talking about feeling hopeless or like a burden, and taking dangerous risks. If you notice these, try to talk openly with the person and get the advice of your doctor.
If you have allergic reactions with Zefretol 400 Tablet , you will have symptoms such as rashes, hives, itching, swelling, trouble swallowing, or difficulty in breathing. The allergic reactions may impact other body parts like liver or blood cells. So, it's better to consult a doctor when you notice the symptoms.
You can usually play sports while taking Zefretol 400 Tablet , but take precautions. Side effects like dizziness or fatigue may affect coordination and reaction time, so stay hydrated, and avoid high-risk sports. However, check with your doctor for better advice.
If your blood sodium levels are low while taking Zefretol 400 Tablet , you may experience an increase in seizures, confusion, decreased consciousness, cognitive disturbances, or reduced awareness. Consult your doctor immediately if you notice any of these symptoms.
Zefretol 400 Tablet , when taken with Carbamazepine, may lead to side effects such as dizziness, drowsiness, confusion, and an increased risk of low blood sodium levels. It may also affect the effectiveness of either medication. Therefore, always consult your doctor before taking Zefretol 400 Tablet with other medicines so that the dose may be adjusted if both medicines are to be used together.

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