Zaglivia 5mg Tablet contains saxagliptin, which belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors used in the treatment of type 2 diabetes in adults. Zaglivia 5mg Tablet is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control their blood sugar levels. It is the first-line therapy for patients with type 2 diabetes that restores the body's response to insulin. Insulin is the hormone that controls sugar levels in your blood. People with type 2 diabetes either do not produce enough insulin, or the insulin produced is unable to perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes.

Zaglivia 5mg Tablet works by blocking the action of DPP-4 (an enzyme which destroys the hormone ‘Incretin’). The enzyme ‘Incretins’ helps to produce more insulin only when required and reduces blood sugar levels produced by the liver when not needed. Zaglivia 5mg Tablet should not be used in patients with type 1 diabetes and for the treatment of diabetic ketoacidosis.

Zaglivia 5mg Tablet should be taken with food or an empty stomach. However, it should be taken at the same time of the day each time for best results. For better advice, your doctor will decide what dose should be taken, and it can change timely depending upon your condition. The most common side effects of Zaglivia 5mg Tablet are hypoglycemia (low blood glucose levels), upper respiratory tract infection, nasopharyngitis (infection of nose and throat with common cold) and headache.

Prolonged intake of Zaglivia 5mg Tablet may cause acute pancreatitis (swollen pancreas), and critical kidney problem. Increased risk of hypoglycemia (low blood sugar level) can occur when Zaglivia 5mg Tablet is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Zaglivia 5mg Tablet. Severe allergic reactions might occur in some patients taking Zaglivia 5mg Tablet, like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions, including Stevens-Johnson syndrome. Safety and efficacy of Zaglivia 5mg Tablet in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Zaglivia 5mg Tablet should be closely monitored as severe drug interaction has been observed.

Zaglivia 5mg Tablet works by blocking the action of DPP-4 (an enzyme which destroys the hormone ‘Incretin’). The enzyme ‘Incretins’ helps to produce more insulin only when required and reduces blood sugar levels produced by the liver when not needed. Thus, Zaglivia 5mg Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

• Hypoglycaemia (low blood glucose levels)
• Upper respiratory tract infection
• Nasopharyngitis (infection of the nose and throat with a common cold)
• Headache

Increased risk of hypoglycemia (low blood sugar level) can occur when Zaglivia 5mg Tablet is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Zaglivia 5mg Tablet. Prolonged intake of Zaglivia 5mg Tablet may cause acute pancreatitis (swollen pancreas) and critical kidney problems. Severe allergic reactions might occur in some patients taking Zaglivia 5mg Tablet, like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions, including Stevens-Johnson syndrome. Safety and efficacy of Zaglivia 5mg Tablet in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Zaglivia 5mg Tablet should be closely monitored as severe drug interaction has been observed.

Drug-Drug Interaction: Zaglivia 5mg Tablet interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine). Other drug interactions can contribute to increased low blood sugar, including sex hormones (androgens), anti-oxidants (alpha-lipoic acid), painkillers (aspirin), anti-TB drugs (prothionamide), growth hormones (pegvisomant), and other antidiabetic medicines.

Drug-Food Interaction: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Zaglivia 5mg Tablet.

Drug-Disease Interaction: Zaglivia 5mg Tablet should be used with caution in patients with a history of pancreatitis/pancreatic disease and renal dysfunction.

• BUPROPION
• CIPROFLOXACIN
• CIMETIDINE
• DIGOXIN
• DOLUTEGRAVIR
• TOPIRAMATE
• RANOLAZINE
• ASPIRIN

• Invest at least 150 min of your week in moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
• Losing weight gradually to achieve a healthy body mass index (18.5 to 24.9).
• Replacing refined carbohydrate-containing foods with whole grain foods and increasing intake of fruits and veggies and other fibre-enriched foods.
• Reduce your intake of saturated fat (or hidden fats) in foods like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
• Avoid too much stress, as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness, meditation, and yoga to control stress-related blood sugar changes.
• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk and cheese etc.).
• Keep your blood pressure as normal (140/90) as possible, as it reduces the risk of cardiovascular diseases in diabetes patients.

Type 2 diabetes is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work properly or is utilized by our body. This can cause high blood sugar levels (hyperglycemia). Symptoms of type 2 diabetes include increased thirst, frequent urination,  increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain, while in rare cases, weight loss may be observed. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and an increase in the chance of heart attack or stroke.