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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Xylistin Forte 3MIU Injection is used to treat bacterial infections. It contains Colistimethate Sodium.  It effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, it destroys the bacteria and successfully treats the infection. Common side effects of Xylistin Forte 3MIU Injection may include injection site reactions, renal damage, visual disturbances, GI disturbances, dizziness, nausea, vomiting and muscle weakness.
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Whats That

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Synonym :

COLISTIN

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Xylistin Forte 3MIU Injection

Xylistin Forte 3MIU Injection belongs to the class of medications called ‘antibiotics’ used to treat bacterial infections. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

Xylistin Forte 3MIU Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Xylistin Forte 3MIU Injection destroys the bacteria and successfully treats the infection.

Xylistin Forte 3MIU Injection will be administered by a qualified healthcare professional. Sometimes, you may experience common side effects like injection site reactions, renal damage, visual disturbances, GI disturbances, dizziness, nausea, vomiting and muscle weakness. But these side effects are usually in the initial phase and resolve over time. However, if these side effects persist, let your doctor know.

Before receiving Xylistin Forte 3MIU Injection, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Xylistin Forte 3MIU Injection can cause blurred vision and dizziness in some people; if this occurs, do not drive or operate tools or machinery. It is recommended not to consume any alcoholic beverages while on treatment with this medicine.

Uses of Xylistin Forte 3MIU Injection

Treatment of Bacterial infections

Directions for Use

Xylistin Forte 3MIU Injection will be administered by a qualified healthcare professional. Do not self-administer.

Medicinal Benefits

Xylistin Forte 3MIU Injection contains Colistimethate Sodium. Colistimethate Sodium, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Xylistin Forte 3MIU Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.

How Xylistin Forte 3MIU Injection Works

Xylistin Forte 3MIU Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Xylistin Forte 3MIU Injection destroys the bacteria and successfully treats the infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Xylistin Forte 3MIU Injection

  • Superinfection (reinfection)
  • Renal damage
  • Visual disturbances
  • GI disturbances
  • Dizziness
  • Nausea
  • Vomiting
  • Confusion
  • Peripheral neuropathy
  • Respiratory insufficiency
  • Muscle weakness

What if I have taken an overdose of Xylistin Forte 3MIU Injection

As Xylistin Forte 3MIU Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Xylistin Forte 3MIU Injection may cause paraesthesia, lethargy, confusion, ataxia, dizziness, apnoea, possible respiratory arrest, and acute renal failure.

Drug Warnings

If you are allergic to Xylistin Forte 3MIU Injection, please inform your physician. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding before receiving Xylistin Forte 3MIU Injection. Also, inform your doctor if you have chronic kidney disease, myasthenia gravis (muscle disorder), and porphyria (a blood disorder). Do not abruptly discontinue taking the prescription since this may result in antibiotic resistance, a condition in which bacteria develop resistance to antibiotics.

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
ColistinGentamicin
Severe

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Coadministration of Xylistin Forte 3MIU Injection 1's along with BCG vaccine can reduce the treatment outcomes.

How to manage the interaction:
Taking Xylistin Forte 3MIU Injection 1's with BCG vaccine is avoided as it may lead to an interaction, please consult your doctor before taking it.
ColistinGentamicin
Severe
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Co-administration of Xylistin Forte 3MIU Injection 1's with Gentamicin can increase the levels and risk of Xylistin Forte 3MIU Injection 1's side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin Forte 3MIU Injection 1's and Gentamicin, you can take these medicines together if prescribed by your doctor. However, if you experience weight gain or loss suddenly, muscle pain, dizziness, or palpitations, call your doctor right away. Do not stop using any medications without a doctor's advice.
ColistinNeomycin
Severe
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Combining Xylistin Forte 3MIU Injection 1's with Neomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Xylistin Forte 3MIU Injection 1's and Neomycin, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinAtracurium
Severe
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Coadministration of Atracurium with Xylistin Forte 3MIU Injection 1's can increase the risk of Atracurium side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin Forte 3MIU Injection 1's and Atracurium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, slurred speech, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinRocuronium bromide
Severe
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Coadministration of Rocuronium bromide with Xylistin Forte 3MIU Injection 1's may increase the side effects of Rocuronium bromide.

How to manage the interaction:
Although there is a possible interaction between Xylistin Forte 3MIU Injection 1's and Rocuronium bromide, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinTenofovir alafenamide
Severe
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Combining Xylistin Forte 3MIU Injection 1's with Tenofovir alafenamide may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Xylistin Forte 3MIU Injection 1's and Tenofovir alafenamide, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience an upset stomach, rash, dizziness, or fever. Do not stop using any medications without a doctor's advice.
ColistinStreptomycin
Severe
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Coadministration of Streptomycin with Xylistin Forte 3MIU Injection 1's may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin Forte 3MIU Injection 1's and Streptomycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, muscle pain, dizziness, or palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ColistinEverolimus
Severe
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Coadministration of Xylistin Forte 3MIU Injection 1's with Everolimus can increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction between Xylistin Forte 3MIU Injection 1's and Everolimus, it can be taken if prescribed by a doctor. However, if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, or weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.
ColistinTobramycin
Severe
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Coadministration of Tobramycin with Xylistin Forte 3MIU Injection 1's can increase the blood levels and risk of Xylistin Forte 3MIU Injection 1's side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin Forte 3MIU Injection 1's and Tobramycin, you can take these medicines together if prescribed by your doctor. However, if you experience, shortness of breath, muscle pain, dizziness, or palpitations, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
ColistinKanamycin
Severe
How does the drug interact with Xylistin Forte 3MIU Injection 1's:
Coadministration of Xylistin Forte 3MIU Injection 1's with Kanamycin can increase the level and risk of Xylistin Forte 3MIU Injection 1's side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin Forte 3MIU Injection 1's and Kanamycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, swelling, muscle pain, dizziness, or palpitations call your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After taking the full course of Xylistin Forte 3MIU Injection, probiotics should be taken to restore some of the healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can restore the intestine's good bacteria stink.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking many calcium-enriched foods and drinks as it might affect the working of Xylistin Forte 3MIU Injection.
  • Avoid intake of alcoholic beverages with Xylistin Forte 3MIU Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Xylistin Forte 3MIU Injection in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

Xylistin Forte 3MIU Injection Substitute

Substitutes safety advice
  • Colist 3MIU Injection 1's

    2551.84per tablet
  • Kuzet 3 miu Injection 1's

    2079.00per tablet
  • Hopstin 3MIU Injection 1's

    2460.00per tablet
  • Colistin 3 miu Injection 1's

    2869.20per tablet
  • Guficol Plus 3Miu Injection 1's

    3822.02per tablet
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Alcohol

Caution

Limit alcohol consumption while on treatment with this medicine as it may worsen drowsiness, dizziness or sleepiness.

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Pregnancy

Caution

Xylistin Forte 3MIU Injection should not be used in pregnancy unless necessary. Hence, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Xylistin Forte 3MIU Injection.

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Breast Feeding

Caution

Xylistin Forte 3MIU Injection should not be used in nursing mothers unless necessary. So, inform your doctor if you are a breastfeeding mother. Your doctor will weigh the benefits and potential risks before prescribing Xylistin Forte 3MIU Injection.

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Driving

Caution

You may have side effects like visual disturbances and dizziness after taking Xylistin Forte 3MIU Injection that may make you unfit to drive or operate machinery. Hence, do not drive or operate machinery until you are feeling well.

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Liver

Safe if prescribed

Inform your doctor before receiving Xylistin Forte 3MIU Injection if you have a liver impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Caution should be exercised while using Xylistin Forte 3MIU Injection in patients with severe kidney disease. Inform your doctor before receiving Xylistin Forte 3MIU Injection if you have a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

FAQs

Xylistin Forte 3MIU Injection is used to treat Bacterial infections.
Xylistin Forte 3MIU Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Xylistin Forte 3MIU Injection destroys the bacteria and successfully treats the infection.
Xylistin Forte 3MIU Injection is contraindicated in people with Hypersensitivity to any component in Xylistin Forte 3MIU Injection. Besides this, it is also contraindicated to use in people with myasthenia gravis (muscle disorder).
Xylistin Forte 3MIU Injection contains Colistimethate Sodium. It is an antibiotic medication used when other drugs or therapy are ineffective. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Xylistin Forte 3MIU Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.
Do not use anti diarrhoeal until the doctor has prescribed you. You can drink plenty of fluids (electrolytes) to avoid dehydration. Besides this, you can also take prebiotics or probiotics to manage diarrhoea as it may help increase the number of good bacteria in the intestine, which aids indigestion.
After taking an antibiotic, you may need to wait up to three hours to eat or drink dairy products, including milk and butter, yoghurt, and cheese. Grapefruit juice and dietary supplements containing minerals like calcium may also work to dampen the effect of antibiotics.
Before taking Xylistin Forte 3MIU Injection, inform your doctor if you have a history of kidney problems, myasthenia gravis (a condition that causes muscle weakness), porphyria (a blood disorder), or asthma. These conditions may affect your treatment or require special monitoring.
Xylistin Forte 3MIU Injection is prescribed during pregnancy only if your doctor thinks that the benefits are greater than the potential risks. The safety of Xylistin Forte 3MIU Injection during pregnancy has not been fully established. Therefore, consult your doctor before taking Xylistin Forte 3MIU Injection if you are pregnant.
Xylistin Forte 3MIU Injection is safe when used as per the dose and duration advised by a doctor.
Xylistin Forte 3MIU Injection is effective when taken as per the doses prescribed by your doctor. Xylistin Forte 3MIU Injection should be administered under medical supervision for optimal results.
If you forget to take a dose of Xylistin Forte 3MIU Injection consult your healthcare provider for advice. Your doctor will guide you on the appropriate steps, but do not administer an extra dose to make up for the missed one.
Xylistin Forte 3MIU Injection causes side effects such as visual disturbances, dizziness, nausea, vomiting, confusion, muscle weakness, respiratory insufficiency, and kidney damage. Therefore, please contact a doctor if any of these side effects persist for longer durations.

Country of origin

INDIA

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - XYL0065

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