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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Xpreza 200 mg Tablet is used in treating Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. It contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

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Whats That

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Composition :

AZACITIDINE-200MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Xpreza 200 mg Tablet

Xpreza 200 mg Tablet belongs to the group of anti-cancer medicines called demethylation agents indicated for continued treatment of acute myeloid leukaemia in adults who improved after chemotherapy but could not complete intensive curative therapy. Acute myeloid leukaemia is a type of cancer that forms in the blood-forming cells of the bone marrow.

Xpreza 200 mg Tablet contains Azacitidine, which works by interfering with the growth of cancer cells, which are eventually destroyed by the body. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

In some cases, Xpreza 200 mg Tablet may cause side effects such as nausea, vomiting, diarrhoea, constipation, fatigue and abdominal pain. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Xpreza 200 mg Tablet if you are pregnant or breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Xpreza 200 mg Tablet . This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Xpreza 200 mg Tablet

Treatment of Acute myeloid leukaemia

Directions for Use

Take Xpreza 200 mg Tablet with or without food. Swallow the medicine as a whole with water; do not crush or chew it.

Medicinal Benefits

Xpreza 200 mg Tablet belongs to the group of anti-cancer medicines called demethylation agents indicated for continued treatment of adult patients with acute myeloid leukaemia who achieved first complete remission (all signs and symptoms of cancer have disappeared) or complete remission with incomplete blood count recovery following intensive induction chemotherapy and are not able to complete intensive curative therapy. Xpreza 200 mg Tablet contains Azacitidine, a nucleoside metabolic inhibitor which works by interfering with the growth of cancer cells, which are eventually destroyed by the body. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

How Xpreza 200 mg Tablet Works

Xpreza 200 mg Tablet contains Azacitidine, which works by interfering with the growth of cancer cells, which are eventually destroyed by the body. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Xpreza 200 mg Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Dizziness
  • Fatigue
  • Abdominal pain
  • Decreased appetite
  • Arthralgia (joint pain)

What if I have taken an overdose of Xpreza 200 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Xpreza 200 mg Tablet may include diarrhoea, nausea, and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Xpreza 200 mg Tablet if you are allergic to any of its components or if you are breastfeeding. Inform the doctor if you have liver or kidney problems. Seek medical attention if you experience symptoms of neutropenia/low white blood cells (fever or chills, feeling very tired or weak, body aches, and unusual headache) or thrombocytopenia/low platelet count (unusual bleeding or bruising). Consult the doctor if you are pregnant, plan to become pregnant, or if you plan to father a child.

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
AzacitidineThalidomide
Severe

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
How does the drug interact with Xpreza 200 mg Tablet 14's:
Taking Yellow fever vaccine with Xpreza 200 mg Tablet 14's can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Xpreza 200 mg Tablet 14's and the Yellow fever vaccine, you can take these medicines together if prescribed by a doctor. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
AzacitidineThalidomide
Severe
How does the drug interact with Xpreza 200 mg Tablet 14's:
Taking thalidomide together with Xpreza 200 mg Tablet 14's may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Xpreza 200 mg Tablet 14's together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
AzacitidineNatalizumab
Severe
How does the drug interact with Xpreza 200 mg Tablet 14's:
Taking Xpreza 200 mg Tablet 14's with Natalizumab can raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Xpreza 200 mg Tablet 14's and Natalizumab, but it can be taken if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm(a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory and personality, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzacitidineBCG vaccine
Severe
How does the drug interact with Xpreza 200 mg Tablet 14's:
Taking BCG vaccine with Xpreza 200 mg Tablet 14's can increase the risk of infection.

How to manage the interaction:
Co-administration of Xpreza 200 mg Tablet 14's with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
AzacitidineBaricitinib
Severe
How does the drug interact with Xpreza 200 mg Tablet 14's:
Taking baricitinib and Xpreza 200 mg Tablet 14's can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Xpreza 200 mg Tablet 14's if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
AzacitidineAdalimumab
Severe
How does the drug interact with Xpreza 200 mg Tablet 14's:
Taking Adalimumab with Xpreza 200 mg Tablet 14's may raise the risk of severe infections.

How to manage the interaction:
Taking Xpreza 200 mg Tablet 14's with Adalimumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineEfalizumab
Severe
How does the drug interact with Xpreza 200 mg Tablet 14's:
Using efalizumab together with Xpreza 200 mg Tablet 14's may increase the risk of serious infections.

How to manage the interaction:
Taking Xpreza 200 mg Tablet 14's with Efalizumab together can result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms - complications, infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, pain or burning during urination - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineFilgrastim
Severe
How does the drug interact with Xpreza 200 mg Tablet 14's:
Coadministration of Filgrastim with Xpreza 200 mg Tablet 14's can reduce the effects of Filgrastim.

How to manage the interaction:
Although there is an interaction between filgrastim and Xpreza 200 mg Tablet 14's, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AzacitidineClozapine
Severe
How does the drug interact with Xpreza 200 mg Tablet 14's:
Using clozapine together with Xpreza 200 mg Tablet 14's can lower white blood cell count and may affect the bone marrow function, that may develop serious infections as a result.

How to manage the interaction:
There may be a possibility of interaction between Xpreza 200 mg Tablet 14's and Clozapine, but it can be taken if prescribed by a doctor. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not stop using any medications without a doctor's advice.
AzacitidineFingolimod
Severe
How does the drug interact with Xpreza 200 mg Tablet 14's:
The use of fingolimod in conjunction with Xpreza 200 mg Tablet 14's may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Xpreza 200 mg Tablet 14's with Fingolimod can possibly result in an interaction, but it can be taken if your doctor has advised it. However, Consult a doctor immediately if you have a fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly as it helps maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Xpreza 200 mg Tablet Substitute

Substitutes safety advice
  • Azatend-O 200 mg Tablet 14's

    by Others

    1158.31per tablet
  • MDS-O 200 mg Tablet 14's

    by Others

    527.09per tablet
  • MDS-O 200mg Tablet

    by Others

    425.23per tablet
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Alcohol

Consult your doctor

It is not known if alcohol affects Xpreza 200 mg Tablet . Please consult your doctor.

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Pregnancy

Unsafe

Xpreza 200 mg Tablet can harm the unborn baby. Avoid becoming pregnant during treatment with Xpreza 200 mg Tablet . Consult the doctor immediately if you become pregnant during treatment with Xpreza 200 mg Tablet .

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Breast Feeding

Unsafe

Avoid breastfeeding during treatment with Xpreza 200 mg Tablet and for one week after the last dose.

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Driving

Consult your doctor

It is unknown if Xpreza 200 mg Tablet affects your ability to drive. Drive only if you are alert.

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Liver

Caution

If you have a history of liver disease, inform your doctor before taking Xpreza 200 mg Tablet .

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before taking Xpreza 200 mg Tablet .

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Children

Unsafe

Xpreza 200 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

FAQs

Xpreza 200 mg Tablet is used to treat Acute myeloid leukaemia.
Xpreza 200 mg Tablet works by helping bone marrow in the production of normal blood cells and killing abnormal cells in the bone marrow.
Xpreza 200 mg Tablet may affect fertility in men and women. Consult the doctor if you have any concerns.
The doctor will prescribe anti-nausea medicine to help prevent nausea and vomiting during treatment with Xpreza 200 mg Tablet . Take the anti-nausea medicine 30 minutes before each dose of Xpreza 200 mg Tablet or as the doctor advises.
If you vomit after taking a dose Xpreza 200 mg Tablet , avoid taking another dose on the same day. Take the next dose at the regular time the next day. Talk to the doctor if you have any concerns.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - XPR0019

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