Worti-20 Tablet belongs to a group of medicines called antidepressants. It is used to treat major depressive episodes in adults. It has been shown to reduce the broad range of depressive symptoms, including sadness, inner tension (feeling anxious), sleep disturbances (reduced sleep), reduced appetite, difficulty concentrating, feelings of worthlessness, and loss of interest in favourite activities, feeling of being slowed down. Depression is a mood disorder that affects a person's daily life and is described as feelings of sadness, loss, or anger. These symptoms may interfere with your daily activities and affect your quality of life.

Worti-20 Tablet contains vortioxetine. It works by increasing serotonin levels, chemicals present in the brain responsible for energy, mood, and behaviour. Hence, an increase in these levels can effectively reduce the symptoms of depression.

Your doctor will decide the right amount to control your symptoms based on your medical condition. Your treatment may be continued for at least six months after your symptoms resolve. Follow your doctor's instructions carefully while taking this medicine. It may take a few weeks before you start to feel better. Do not change the dose or stop taking medication, even if you feel well. Doing so may make your condition worse. Common side effects of Worti-20 Tablet  include abnormal dreams, constipation, diarrhoea, dizziness, itching, nausea and vomiting. These side effects usually go away after discontinuation of treatment. However, inform your doctor immediately if these side effects persist or worsen.

Taking Worti-20 Tablet if you are allergic to Worti-20 Tablet or its contents is not recommended. Before taking Worti-20 Tablet , inform your doctor if you have seizures (fits), head injury, severe liver, kidney, heart problems, diabetes, adrenal gland tumours, urination problems, glaucoma (an eye disease), and manic depressive illness or other mental disorders. Elderly patients may require dose adjustments. Avoid taking alcohol, as it can cause excessive drowsiness. Worti-20 Tablet may cause drowsiness, so avoid driving or operating heavy machinery if you feel drowsy. If you are pregnant or breastfeeding, think you may be pregnant, or plan to have a baby, ask your doctor for advice before taking this medicine. Worti-20 Tablet is not recommended in children and adolescents under 18 years due to a lack of information for this age group.

Worti-20 Tablet contains ‘vortioxetine’, an antidepressant that is effective and well-tolerated. It increases serotonin levels, a chemical in the brain responsible for energy, mood, and behaviour. Hence, an increase in these levels can effectively reduce the symptoms of depression.

• Abnormal dreams

• Constipation

• Diarrhoea

• Dizziness

• Itching

• Nausea

• Vomiting

It is not recommended to take Worti-20 Tablet if you are allergic to Worti-20 Tablet or its contents. Before taking Worti-20 Tablet , inform your doctor if you have seizures (fits), head injury, severe liver, kidney, heart problems, diabetes, adrenal gland tumors, urination problems, glaucoma (an eye disease), and manic depressive illness or other mental disorders. Avoid taking alcohol, as it can cause excessive drowsiness. Elderly patients may require dose adjustments. Worti-20 Tablet may cause drowsiness, so avoid driving or operating heavy machinery if you feel drowsy. If you are pregnant or breastfeeding, think you may be pregnant, or plan to have a baby, ask your doctor for advice before taking this medicine. Worti-20 Tablet is not recommended in children and adolescents under 18 years due to a lack of information for this age group.

Drug-Drug Interactions:  Worti-20 Tablet may interact with medicines used to treat hyperactivity disorder (amphetamine/dextroamphetamine, methylphenidate, lisdexamfetamine), antidepressants (duloxetine, desvenlafaxine, mirtazapine, bupropion, sertraline), and medicines to treat seizures (lamotrigine, pregabalin).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Worti-20 Tablet should not be used in patients with severe depression, angle-closure glaucoma, bleeding, hyponatremia (a condition where sodium levels in the blood are lower than normal), mixed/manic episode.

• AMPHETAMINE
• DEXTROAMPHETAMINE
• METHYLPHENIDATE
• LISDEXAMFETAMINE
• DULOXETINE
• DESVENLAFAXINE
• MIRTAZAPINE
• BUPROPION
• SERTRALINE
• LAMOTRIGINE
• PREGABALIN

• Regularly attend therapy sessions.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters.
• Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
• Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosting self-esteem, and provides restful sleep.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors, and follow the doctor’s treatment plan.

• Inform your doctor that you are taking Worti-20 Tablet before undergoing any surgery, medical or dental treatment.
• Do not discontinue the treatment abruptly without discussing it with your doctor. The doctor gradually reduces the dose before completely stopping the treatment from avoiding withdrawal reactions.

Depression: It is a mood disorder characterized by the persistent feeling of sadness, unhappiness, anger, hopelessness, or loss that interferes with a person’s daily activities. Depression can also influence some chronic health conditions and relationships. In this condition, neurotransmitters (chemicals in the brain) such as dopamine, serotonin, and noradrenaline levels decrease, resulting in symptoms of depression. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions. Counselling (psychotherapy) and antidepressants can be used to treat depression.