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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Votrient 400 mg Tablet is an anti-cancer drug used in the treatment of kidney and soft tissue cancer. It contains Pazopanib, which works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. Thus, it stops the spread of cancerous cells. It may cause common side effects such as itching or skin rash, acne, dry skin, vomiting, diarrhea and loss of appetite.
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Composition :

PAZOPANIB-400MG

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Votrient 400 mg Tablet

Votrient 400 mg Tablet belongs to the group of medicine called ‘anti-cancer’ that is primarily indicated in the treatment of kidney and soft tissue cancer.  Kidney cancer also known as renal cancer is a disease in which healthy cells of the kidney become malignant (cancerous), grow in an uncontrolled manner and forms a tumor. When a group of cancer occurs in different parts of the body such as bones, muscles, deep layers of skin, and fat then it is known as soft tissue sarcomas. This type of cancer may also form in nerves, blood vessels or connective tissues that support organs of the body.

Votrient 400 mg Tablet contains 'Pazopanib' which falls in the category of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take Votrient 400 mg Tablet as prescribed by your doctor. You are suggested to take Votrient 400 mg Tablet as long as your doctor has prescribed it after checking your medical condition.  In some cases, you may experience certain common side effects such as itching or skin rash, acne, dry skin, vomiting, diarrhea and loss of appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Votrient 400 mg Tablet for as long as your doctor has prescribed. Do not take Votrient 400 mg Tablet if you are pregnant or planning for pregnancy as Votrient 400 mg Tablet causes serious birth defects. Votrient 400 mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk and may cause possible risk to the infant. Elderly people are more sensitive to medicine so the doctor may adjust the dosage according to the condition. Avoid consuming alcohol along with Votrient 400 mg Tablet as it could lead to increased dizziness.

Uses of Votrient 400 mg Tablet

Treatment of Kidney cancer, Soft tissue cancer

Directions for Use

Votrient 400 mg Tablet can be taken without food on an empty stomach at least one or two hours before taking a meal or take it as advised by your doctor. Swallow it as a whole with a glass of water; do not crush, break or chew it.

Medicinal Benefits

Votrient 400 mg Tablet is a ' tyrosine kinase inhibitor (TKI)', that stops the uncontrolled growth and spread of cancerous cells. Votrient 400 mg Tablet is effective in treating thyroid, liver and kidney cancer. It acts by stopping the action of the abnormal protein that is responsible for the multiplication of cancerous cells. Whenever a new healthy cell is formed it undergoes a usual process of maturity. Cancerous cells form new cells more quickly so Votrient 400 mg Tablet targets cancerous cells and blocks the action of Tyrosine kinases enzymes (responsible for causing cancer). It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Votrient 400 mg Tablet stops the production, spread and growth of cancerous cells in the body.

How Votrient 400 mg Tablet Works

Votrient 400 mg Tablet contains 'Pazopanib' which falls in the category of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Votrient 400 mg Tablet

  • Acne
  • Dry skin
  • Nausea
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Itching or skin rash

What if I have taken an overdose of Votrient 400 mg Tablet

Do not take more than the prescribed dose of Votrient 400 mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Votrient 400 mg Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side-effects. Before your doctor prescribes you Votrient 400 mg Tablet , tell them if you have heart problems, high blood pressure, bleeding issues, surgery or an electrolyte imbalance (like abnormal levels of magnesium, calcium  or potassium in the blood). Votrient 400 mg Tablet is restricted to use in persons who are sensitive to any of its constituents or have squamous cell lung cancer or already taking carboplatin and paclitaxel.

Drug-Drug Interactions

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PazopanibPimozide
Critical
PazopanibCisapride
Critical

Drug-Drug Interactions

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PazopanibPimozide
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Taking Pimozide with Votrient 400 mg Tablet 30's can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Votrient 400 mg Tablet 30's with Pimozide is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibCisapride
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Using cisapride together with Votrient 400 mg Tablet 30's can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Votrient 400 mg Tablet 30's with Cisapride is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibDronedarone
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Taking dronedarone together with Votrient 400 mg Tablet 30's can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Votrient 400 mg Tablet 30's with Dronedarone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibSparfloxacin
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Using Votrient 400 mg Tablet 30's together with sparfloxacin can increase the risk of abnormal heart rhythm

How to manage the interaction:
Taking Votrient 400 mg Tablet 30's with Sparfloxacin is not recommended, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PazopanibHalofantrine
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Using Votrient 400 mg Tablet 30's together with halofantrine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Votrient 400 mg Tablet 30's with Halofantrine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibMesoridazine
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Co-administration of Votrient 400 mg Tablet 30's with mesoridazine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Votrient 400 mg Tablet 30's is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibZiprasidone
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Taking Votrient 400 mg Tablet 30's with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Votrient 400 mg Tablet 30's and Ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibChloroquine
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Taking Votrient 400 mg Tablet 30's with chloroquine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Votrient 400 mg Tablet 30's with Chloroquine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibBCG vaccine
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Taking BCG vaccine with Votrient 400 mg Tablet 30's can increase the risk of infection.

How to manage the interaction:
Taking Votrient 400 mg Tablet 30's with BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
PazopanibThioridazine
Critical
How does the drug interact with Votrient 400 mg Tablet 30's:
Taking Votrient 400 mg Tablet 30's with Thioridazine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Votrient 400 mg Tablet 30's with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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PAZOPANIB-400MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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PAZOPANIB-400MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Coadministration of Votrient 400 mg Tablet 30's with grapefruit juice can increase the blood levels of Votrient 400 mg Tablet 30's, which may lead to an increased risk of serious side effects such as liver problems, irregular heart rhythm, bleeding, and high blood pressure. Avoid taking grapefruit juice along with Votrient 400 mg Tablet 30's, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles reduce fatigue, helps in weight loss and give strength. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga and other relaxation techniques may also help in improving physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting helps in improving your health, mental ability, and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing fiber help in better digestion. These include beans, peas, lentils, whole grains,  nuts, and seeds.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Votrient 400 mg Tablet Substitute

Substitutes safety advice
  • Pazoci 400 Tablet 30's

    273.20per tablet
  • Pazib 400 Tablet 30's

    103.87per tablet
  • Pazotab 400 mg Tablet 30's

    159.05per tablet
  • Pazolit 400 mg Tablet 30's

    150.33per tablet
  • Pazonat 400 Tablet 30's

    164.00per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Votrient 400 mg Tablet as it may increase the risk of side effects such as dizziness, drowsiness or difficulty in concentrating.

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Pregnancy

Unsafe

Votrient 400 mg Tablet is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or for at least 6 months after taking the last dose of Votrient 400 mg Tablet .

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Breast Feeding

Unsafe

Votrient 400 mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk and may cause possible risk to the infant.

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Driving

Caution

It is not known if Votrient 400 mg Tablet may affect your driving ability or not.

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Liver

Safe if prescribed

Votrient 400 mg Tablet should be taken with caution in patients dealing with the liver disease. The dose may be adjusted by the doctor according to the medical condition of the patient.

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Kidney

Safe if prescribed

Votrient 400 mg Tablet is safe to take by patients dealing with kidney cancer as prescribed by their doctor. The dose may be adjusted by the doctor according to the medical condition of the patient.

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Children

Unsafe

Votrient 400 mg Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

FAQs

Votrient 400 mg Tablet is used in the treatment of kidney and soft tissue cancer.
Votrient 400 mg Tablet is safe to be taken by a diabetic person. However, take Votrient 400 mg Tablet only after asking with a doctor as they may adjust the dosing according to the condition of the patient.
Votrient 400 mg Tablet is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or for at least 6 months after taking the last dose of Votrient 400 mg Tablet .
Votrient 400 mg Tablet should be stopped in cases where a person faces serious side effect that affects the quality of life. Otherwise, you need to keep taking Votrient 400 mg Tablet until your doctor asks you to stop it.
Before your doctor prescribes you Votrient 400 mg Tablet , tell them if you have heart problems, high blood pressure, bleeding issues, surgery or an electrolyte imbalance (like abnormal levels of magnesium, calcium, or potassium in the blood).
Votrient 400 mg Tablet is restricted to use in persons who are sensitive to any of its constituents or have squamous cell lung cancer or already taking carboplatin and paclitaxel.
Votrient 400 mg Tablet is not a chemotherapy medicine. It belongs to an anti-cancer group of medicines called protein kinase inhibitors. Votrient 400 mg Tablet works by preventing the activity of proteins that are involved in the growth and spread of cancer cells.
Take Votrient 400 mg Tablet by orally as prescribed by your physician. Consume it whole with water. Breaking or crushing it will interfere with Votrient 400 mg Tablet 's absorption and raise the chance of adverse effects.
No, Votrient 400 mg Tablet should not be taken with food as it increases the amount of Votrient 400 mg Tablet absorbed into the body and may increase the risk of side effects. It is best to take it on an empty stomach, either 1 hour before or 2 hours after a meal. However, always take Votrient 400 mg Tablet as advised by your doctor.
It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Regular check-ups and imaging tests will help your doctor assess the effectiveness of the treatment. However, it is important to monitor for side effects like diarrhoea, high blood pressure, and fatigue, and consult your doctor if you have any concerns.
Yes, there are some food restrictions while taking Votrient 400 mg Tablet . You are recommended to avoid grapefruit and grapefruit juice, as it may increase the risk of side effects. If you have any concerns about foods to avoid while taking Votrient 400 mg Tablet , please discuss with your doctor.
The duration for taking Votrient 400 mg Tablet can vary depending on your specific condition, the severity of your disease, and how well you respond to the treatment. It is important to follow your doctor's instructions regarding the duration of treatment. Do not stop unless your doctor advises you to.
Some important things you should know about Votrient 400 mg Tablet are side effects it may cause such as serious or life-threatening liver damage. If you experience any of the following symptoms like yellowing of the skin or eyes, dark urine , extreme tiredness , nausea, vomiting , loss of appetite, pain in the upper right part of the stomach, unusual bleeding or bruising, inform your doctor. Votrient 400 mg Tablet should be used with caution in patients with liver disease.

Country of origin

INDIA

Manufacturer/Marketer address

Stiefel India Ltd., 401& 402, A Wing, IV Floor, Floral Deck Plaza, Opp. Rolta Bhavan, Central MIDC Road, Andheri (East), Mumbai – 400093
Other Info - VOT0011

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