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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:45 PM IST

Vingraf 1 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

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Composition :

TACROLIMUS-1MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Vingraf 1 Capsule

Vingraf 1 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Vingraf 1 Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Take Vingraf 1 Capsule as prescribed. You are advised to use Vingraf 1 Capsule for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Vingraf 1 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Vingraf 1 Capsule . Avoid alcohol consumption with Vingraf 1 Capsule . Drive only if you are alert, as Vingraf 1 Capsule may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Vingraf 1 Capsule . Vingraf 1 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Vingraf 1 Capsule

Vingraf 1 Capsule is used for prevention of transplanted organ rejection

Medicinal Benefits

Vingraf 1 Capsule contains Tacrolimus, an immunosuppressant used to prevent organ rejection after a transplant. Vingraf 1 Capsule suppresses the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

Side Effects of Vingraf 1 Capsule

  • Nausea
  • Diarrhoea
  • Headache
  • Kidney problems
  • Infection
  • Constipation
  • Fever
  • High blood pressure

Directions for Use

Capsule: Take the capsule as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.Granules: The granules should be mixed with water to make an oral suspension. Drink the prepared suspension immediately. Do not save the suspension for later use.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Please tell your doctor if you are allergic to Tacrolimus or other medicines. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Vingraf 1 Capsule . Avoid alcohol consumption with Vingraf 1 Capsule . Drive only if you are alert, as Vingraf 1 Capsule may cause vision problems or nervous disturbances in some people. If you are about to get vaccinated, inform your doctor before taking Vingraf 1 Capsule . Vingraf 1 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system. While taking Vingraf 1 Capsule , you are advised to wear protective clothing and sunscreen while going out. You are recommended to use glass or metal materials to prepare the oral suspension. Avoid using plastic (PVC) materials to prepare the suspension, as the granules will stick to a plastic container, and your child may not receive their full dose. Do not inhale or let the granules or prepared oral suspension come in contact with your skin or eyes. In case of accidental contact with skin, wash the area well with soap and water, and if it comes in contact with the eyes, rinse with plain water.

Therapeutic Class

IMMUNOSUPPRESSANTS

Drug-Drug Interactions

verifiedApollotooltip
TacrolimusThioridazine
Critical
TacrolimusMifepristone
Critical

Drug-Food Interactions

verifiedApollotooltip
TACROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate

Diet & Lifestyle Advise

  • Include fruits and vegetables in your daily routine.
  • Follow a vitamin-C-rich diet.
  • Reduce salt intake.
  • Eat a handful of walnuts and almonds every day.
  • Reduce intake of unhealthy cholesterol and fats.
  • Consume dark chocolate with at least 70% cocoa.

Liver and Heart transplant:

  • Eat whole-grain bread, cereals and other grains, fruits and vegetables, lean meats, fish and poultry.
  • Maintain a low-fat and low-salt diet.
  • Drink low-fat milk or eat other low-fat dairy products to maintain adequate calcium.
  • Stay hydrated by drinking sufficient water and other fluids.
  • Avoid alcohol consumption.
  • Avoid grapefruit and grapefruit juice. 

Habit Forming

No

How Vingraf 1 Capsule Works

Vingraf 1 Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

What if I have taken an overdose of Vingraf 1 Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. This medicine may be harmful if swallowed. Seek emergency medical attention or call your doctor if you notice any unusual symptoms or if anyone has accidentally swallowed the medication.
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Alcohol

Unsafe

Avoid alcohol consumption with Vingraf 1 Capsule as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Vingraf 1 Capsule .

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Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Vingraf 1 Capsule and if you are a woman of childbearing age, use effective contraceptive methods while using Vingraf 1 Capsule .

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Breast Feeding

Consult your doctor

Vingraf 1 Capsule may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Vingraf 1 Capsule . You should avoid taking Vingraf 1 Capsule during breastfeeding or avoid breastfeeding while on treatment with Vingraf 1 Capsule .

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Driving

Caution

Vingraf 1 Capsule may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Vingraf 1 Capsule .

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Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Vingraf 1 Capsule .

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Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Vingraf 1 Capsule .

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Children

Safe if prescribed

Vingraf 1 Capsule should be used in children in doses as advised by a doctor only.

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - VIN0010

Author Details

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FAQs

Vingraf 1 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart.
Vingraf 1 Capsule contains Tacrolimus, an immunosuppressant that works by the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.
Vingraf 1 Capsule may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as sore throat or fever.
Vingraf 1 Capsule may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for a long time or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.
If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Vingraf 1 Capsule because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.
Using Vingraf 1 Capsule with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Vingraf 1 Capsule with other medications.
Vingraf 1 Capsule may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.
Vingraf 1 Capsule is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.
Vingraf 1 Capsule is a macrolide antibiotic with immunosuppressant properties.
Vingraf 1 Capsule should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.
Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.
Vingraf 1 Capsule decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).
No, Vingraf 1 Capsule does not have an abuse potential as it is not a controlled substance.
Side effects of Vingraf 1 Capsule include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.

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