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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
VAPRIN TABLET helps to reduce the pain/inflammation in rheumatoid arthritis conditions and keep the immune system from attacking new transplant organs like kidneys. Besides this, it also treats pain and inflammation in gastrointestinal issues like Crohn's disease, and ulcerative colitis, for patients who have undergone a kidney transplant. It contains Azathioprine, which works by reducing the function of the cells, causing inflammation, especially in the joint tissues thereby decreasing pain, inflammation, and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. This medicine helps stop your body from rejecting a new organ by suppressing your immune system. In some cases, you may experience certain common side effects such as nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat.
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Composition :

AZATHIOPRINE

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About VAPRIN TABLET

VAPRIN TABLET is used to reduce the pain/inflammation in rheumatoid arthritis conditions and keep the immune system from attacking new transplant organs like kidneys. Besides this, it also treats pain and inflammation in gastrointestinal issues like Crohn's disease and ulcerative colitis for patients who have undergone a kidney transplant. 

VAPRIN TABLET contains 'Azathioprine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. VAPRIN TABLET helps stop your body from rejecting a new organ by suppressing your immune system. 

Take VAPRIN TABLET as prescribed. Your doctor will advise you on how often you take VAPRIN TABLET based on your medical condition. In some cases, you may experience certain common side-effects such as nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking VAPRIN TABLET for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take VAPRIN TABLET if you are pregnant or planning for pregnancy. VAPRIN TABLET should not be taken by breastfeeding mothers as it passes into breast milk. VAPRIN TABLET should not be given to children as safety and efficacy have not been established. VAPRIN TABLET may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using VAPRIN TABLET . While taking VAPRIN TABLET , do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person who has them, please inform your doctor immediately, as special treatment is required if you have not had these illnesses. Your doctor may advise you to undergo regular blood tests and kidney and liver tests to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Uses of VAPRIN TABLET

Treatment of Rheumatoid arthritis, Immunosuppressant therapy after kidney transplant.

Directions for Use

Swallow VAPRIN TABLET as a whole with water; do not crush, break or chew it.

Medicinal Benefits

VAPRIN TABLET contains 'Azathioprine', which is an immunosuppressant that works by reducing the function of the cells and causing inflammation in the joint tissues. It reduces pain and inflammation and slows joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. VAPRIN TABLET helps stop your body from rejecting a new organ by suppressing your immune system. VAPRIN TABLET is also used to treat severe inflammatory diseases of the skin, Crohn's disease, ulcerative colitis, and some blood disorders.

How VAPRIN TABLET Works

VAPRIN TABLET contains 'Azathioprine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. VAPRIN TABLET helps stop your body from rejecting a new organ by suppressing your immune system.

Storage

Store in a cool and dry place away from sunlight

Side Effects of VAPRIN TABLET

  • Nausea
  • Headaches
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Increase in liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Stomach pain
  • Leukopenia (decreased number of white blood cells)
  • Sore throat

What if I have taken an overdose of VAPRIN TABLET

Do not take more than the prescribed dose of VAPRIN TABLET as it may cause overdose. The symptoms of overdose include diarrhoea, nausea, vomiting, fever, sore throat, chills and other signs of infection. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take VAPRIN TABLET if you are allergic to any immunosuppressant medicines or Azathioprine. Let your doctor know before using VAPRIN TABLET if you have liver or kidney problems, serious blood disorders, immune system problems, bone marrow problems, serious infections, immunodeficiency syndrome, or if you have a condition where your body produces too little of a natural chemical called thiopurine methyltransferase (TPMT), received any vaccinations. Do not take VAPRIN TABLET if you are pregnant or planning for pregnancy as VAPRIN TABLET is a Pregnancy category risk D medicines which can cause serious congenital disabilities to the unborn baby. VAPRIN TABLET should not be taken by breastfeeding mothers as it passes into breast milk. While taking VAPRIN TABLET , do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person having them, please inform your doctor immediately as it requires special treatment if you have not had these illnesses. VAPRIN TABLET causes dizziness and drowsiness, so drive with caution. VAPRIN TABLET should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol along with VAPRIN TABLET as it could lead to increased dizziness. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Using VAPRIN TABLET for a long time can increase your chance of getting certain types of cancer, such as lymphoma (cancer of the spleen, thymus gland, and bone marrow), leukemia (blood cancer), and skin cancer. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using VAPRIN TABLET .

Drug-Drug Interactions

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AzathioprineFebuxostat
Critical
AzathioprineBCG vaccine
Severe

Drug-Drug Interactions

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AzathioprineFebuxostat
Critical
How does the drug interact with VAPRIN TABLET 10'S:
Taking VAPRIN TABLET 10'S and Febuxostat together can increase the blood levels of VAPRIN TABLET 10'S

How to manage the interaction:
Taking VAPRIN TABLET 10'S with Febuxostat is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AzathioprineBCG vaccine
Severe
How does the drug interact with VAPRIN TABLET 10'S:
Taking the BCG vaccine with VAPRIN TABLET 10'S can increase the risk of infection.

How to manage the interaction:
Co-administration of VAPRIN TABLET 10'S with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
AzathioprineMercaptopurine
Severe
How does the drug interact with VAPRIN TABLET 10'S:
The combined use of VAPRIN TABLET 10'S with Mercaptopurine together can increase the risk of side effects.

How to manage the interaction:
Co-administration of VAPRIN TABLET 10'S with Mercaptopurine can possibly result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately, if you experience any symptoms such as bruising or bleeding, fever, chills, sore throat, flu symptoms, mouth sores, black urine, severe stomach pain, jaundice (yellowing of the skin or eyes), or severe nausea, vomiting, or diarrhea. Do not stop using any medications without a doctor's advice.
AzathioprineTeriflunomide
Severe
How does the drug interact with VAPRIN TABLET 10'S:
When VAPRIN TABLET 10'S is taken with Teriflunomide, may raise the risk of side effects affecting bone marrow function, resulting in low levels of different types of blood cells. This can increase your chances of developing anemia, bleeding issues, or infections.

How to manage the interaction:
Taking VAPRIN TABLET 10'S with Teriflunomide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience paleness, exhaustion, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineAdalimumab
Severe
How does the drug interact with VAPRIN TABLET 10'S:
When VAPRIN TABLET 10'S and Adalimumab are taken together, they may raise the risk of severe infections.

How to manage the interaction:
Although there is a possible interaction between VAPRIN TABLET 10'S and Adalimumab, you can take these medicines together if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm (a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineTofacitinib
Severe
How does the drug interact with VAPRIN TABLET 10'S:
The use of tofacitinib with VAPRIN TABLET 10'S may raise the risk of severe infections.

How to manage the interaction:
Co-administration of VAPRIN TABLET 10'S with Tofacitinib can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
AzathioprineClozapine
Severe
How does the drug interact with VAPRIN TABLET 10'S:
When VAPRIN TABLET 10'S and Clozapine are taken together can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of VAPRIN TABLET 10'S with Clozapine can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
AzathioprineEtanercept
Severe
How does the drug interact with VAPRIN TABLET 10'S:
When Etanercept is used with VAPRIN TABLET 10'S, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between VAPRIN TABLET 10'S and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AzathioprineAllopurinol
Severe
How does the drug interact with VAPRIN TABLET 10'S:
Co-administration of Allopurinol with VAPRIN TABLET 10'S may increase the effects of VAPRIN TABLET 10'S.

How to manage the interaction:
There may be a possibility of interaction between VAPRIN TABLET 10'S and allopurinol, but it can be taken if prescribed by a doctor. However, if you experience chills, fever, body pains, sore throat, weakness, muscle pain, mouth sores, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhoea, consult a doctor. Do not stop using any medications without a doctor's advice.
AzathioprineInfliximab
Severe
How does the drug interact with VAPRIN TABLET 10'S:
Coadministration of VAPRIN TABLET 10'S and Infliximab can increase the risk or severity of developing infections.

How to manage the interaction:
Although taking Infliximab and VAPRIN TABLET 10'S together can cause an interaction, it can be taken if a doctor has suggested it. If you have any symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.

  • Acupuncture, massage, and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

  • Avoid smoking and alcohol consumption.

 

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking VAPRIN TABLET . It could lead to increased dizziness and drowsiness.

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Pregnancy

Caution

VAPRIN TABLET is a Category D pregnancy drug that is not recommended for pregnant women or given only when strictly guidance of the doctor as there is no clinical data available on use in pregnant women.

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Breast Feeding

Caution

It is not recommended to take VAPRIN TABLET while you are breastfeeding. VAPRIN TABLET passes into breast milk.

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Driving

Caution

VAPRIN TABLET may cause dizziness, drowsiness, and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Take VAPRIN TABLET only after the doctor's prescription, especially if you are dealing with Liver diseases/conditions as your doctor may adjust the dose as required.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking VAPRIN TABLET .

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Children

Unsafe

VAPRIN TABLET should not be used by children below 18 years of age, as the efficacy and safety have not been established.

FAQs

VAPRIN TABLET is used in treating Rheumatoid arthritis and immunosuppressant therapy after kidney transplant.
VAPRIN TABLET causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.
VAPRIN TABLET acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby provides relief from rheumatoid arthritis.
If you miss a dose of VAPRIN TABLET , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
Diarrhoea might be a side-effect of VAPRIN TABLET . Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.
VAPRIN TABLET is a Category D pregnancy drug that is not recommended for pregnant women or given only when strictly guidance of the doctor as there is no clinical data available on use in pregnant women.
VAPRIN TABLET starts to work gradually. it can take up to 12 weeks of taking the right adjusted dose before you notice any benefits.
If you miss a prescription dose, take it as soon as you recall and resume your regular routine. If you are near the next dose, skip the missing dose and resume your regular schedule. Do not take a double dose to make up for a forgotten dose.
It depends on your individual medical condition and response to the medication. Your doctor will determine the appropriate duration of treatment based on your specific needs.
Taking VAPRIN TABLET for a long time can increase your risk of developing some types of cancer, including skin cancer. As a result, avoid direct sunlight, apply sunscreen (SPF 30 or higher), and wear in clothes that shield your arms and legs.
You'll have regular blood tests while taking azathioprine. These tests will ensure that any concerns or problems are found quickly.
VAPRIN TABLET may have an effect on your liver, kidneys, or bone marrow. Before you begin taking this medication, you will undergo blood tests to assess your liver function, renal function, and blood count. From week one to week eight of your treatment, you will undergo at least one blood test every week.
Yes, taking VAPRIN TABLET for a long time can increase your risk of developing some types of cancer, including skin cancer. Seek medical attention if you experience any changes in your body.
Using Cyclosporine together with VAPRIN TABLET may decrease the effects of cyclosporine. Caution is advised if Cyclosporine must be taken with VAPRIN TABLET . You may need a dose adjustment or special test if you use both medications.
Alcohol does not affect the way azathioprine works. However, both azathioprine and alcohol can affect your liver. For this reason, limit or avoid the consumption of alcohol is recommended.
Common side effects of VAPRIN TABLET may include nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - VAP0024

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