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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Last Updated Oct 9, 2024 | 12:36 PM IST
Valpro Injection 5 ml is an anti-epileptic medication used in the treatment of severe epileptic seizures/fits, to prevent seizures during or after severe head injury and/or neurosurgery. This medicine works by decreasing the abnormal electrical activity in the brain and thus reduces seizures. Common side effects include sleepiness, dizziness, nausea, headache, and weakness.
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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Protech Telelinks

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Valpro Injection 5 ml

Valpro Injection 5 ml belongs to the group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Valpro Injection 5 ml is also used to treat bipolar disorder. Epilepsy is a central nervous system disorder characterized by a sudden rush of electrical activity in the brain leading to seizures, unusual behavior, and loss of awareness. Bipolar disorder is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. 
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Valpro Injection 5 ml contains 'Sodium valproate', which decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures. Valpro Injection 5 ml increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 
 
Valpro Injection 5 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side-effects such as sleepiness, dizziness, nausea, headache, and asthenia (weakness). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

If you are of childbearing age, use effective contraception while on treatment with Valpro Injection 5 ml. Inform your doctor before taking Valpro Injection 5 ml if you are pregnant or breastfeeding. Do not drive or operate machinery as Valpro Injection 5 ml may cause sleepiness and dizziness. Avoid consuming alcohol along with Valpro Injection 5 ml as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Valpro Injection 5 ml

Treatment of Epilepsy/seizures and Bipolar disorder

Medicinal Benefits

Valpro Injection 5 ml belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy (fits). Valpro Injection 5 ml decreases the excessive and abnormal nerve activity in the brain, thereby controlling seizures. Additionally, Valpro Injection 5 ml is also used to treat bipolar disorder. Valpro Injection 5 ml increases the amount of a chemical substance called GABA; this helps block the nerve transmission across the brain and provides a calming effect. Thereby helps treat bipolar disorder. 

Directions for Use

Valpro Injection 5 ml will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Valpro Injection 5 ml

  • Somnolence (sleepiness)
  • Dizziness
  • Nausea
  • Headache
  • Asthenia (weakness)
  • Paresthesia (prickling or burning sensation)

Drug Warnings

Do not take Valpro Injection 5 ml if you are allergic to any of its contents, if you have urea cycle problems, mitochondrial disorders, or hepatic disease/dysfunction. Inform your doctor if you have/had liver problems, porphyria (blood disorder), diabetes, immune system disorder, bleeding problems, systemic lupus erythematosus (a rare skin condition), or kidney problems. Valpro Injection 5 ml may cause hepatotoxicity (liver damage); consult your doctor if you experience symptoms such as weakness, facial swelling, vomiting, malaise (general discomfort), lethargy (lack of energy or enthusiasm), and anorexia (eating disorder). Valpro Injection 5 ml may also cause pancreatitis (inflammation of the pancreas); consult your doctor if you experience symptoms such as abdominal pain, vomiting, nausea, and/or anorexia (eating disorder).

Drug Interactions

Drug-Drug Interactions: Valpro Injection 5 ml may interact with pain killers (aspirin), anti-epileptics (phenobarbital, primidone, phenytoin, carbamazepine, topiramate, lamotrigine, felbamate, ethosuximide), blood thinner (warfarin), anti-HIV (zidovudine), anti-depressant (diazepam, amitriptyline, nortriptyline), antimycobacterial (rifampin), 

Drug-Food Interactions: Avoid alcohol consumption while taking Valpro Injection 5 ml as it might cause increased dizziness and sleepiness. 

Drug-Disease Interactions: Inform your doctor if you have depression, liver disease, urea cycle disorders, suicidal tendency, HIV disease, hereditary mitochondrial disorders, or thrombocytopenia (low levels of platelets).

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PHENOBARBITAL
  • PHENYTOIN
  • PRIMIDONE
  • CARBAMAZEPINE
  • TOPIRAMATE
  • LAMOTRIGINE
  • FELBAMATE
  • ETHOSUXIMIDE
  • WARFARIN
  • ZIDOVUDINE
  • DIAZEPAM
  • AMITRIPTYLINE
  • NORTRIPTYLINE
  • RIFAMPICIN

Habit Forming

No

Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for the generation of energy.
  • Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps in maintaining weight and improving overall health. 
  • Rest well; get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improve coping skills.
  • Have a seizure response plan that helps those around you know what to do.
  • Prepare your living area; small changes may help in reducing the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Special Advise

  • Contact your doctor immediately if you develop suicidal thoughts such as harming or killing yourself.
  • Regular tests such as serum liver tests, platelet count, coagulation tests, and ammonia level tests are advised whilst on treatment with Valpro Injection 5 ml.
  • If you are of childbearing age, use effective contraception during the entire treatment with Valpro Injection 5 ml.
  • Consult your doctor immediately if you become pregnant while on treatment with Valpro Injection 5 ml.

Disease/Condition Glossary

Epilepsy/Seizures: Seizures, also known as fits or convulsions, is a single occurrence of abnormal electrical activity in the brain, whereas epilepsy is a chronic neurological disorder characterized by recurrent seizures. The possible causes of epilepsy include traumatic brain injury, scarring on the brain after a brain injury, high fever, stroke, vascular diseases, lack of oxygen to the brain, brain tumour, and genetic disorders. Symptoms include mood changes, anxiousness, nausea, dizziness, weakness, headache, muscle jerking, spasms, loss of balance, teeth clenching, rapid blinking or eye movements, biting the tongue, confusion, and loss of consciousness.

Bipolar disorder: Bipolar disorder, also known as manic depression or bipolar disease, is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. Symptoms of manic episodes include high energy, loss of touch with reality, and reduced need for sleep. Symptoms of depressive episodes include low motivation, low energy, and loss of interest in daily life.

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Valpro Injection 5 ml as it may cause increased dizziness and sleepiness.

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Pregnancy

Caution

Valpro Injection 5 ml may cause serious congenital defects and decreased IQ. Therefore, Valpro Injection 5 ml should be given to pregnant women with epilepsy only if other medicines have failed to control their symptoms or are unacceptable.

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Breast Feeding

Caution

Valpro Injection 5 ml may pass into breastmilk. Consult your doctor before taking Valpro Injection 5 ml if you are breastfeeding.

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Driving

Unsafe

Valpro Injection 5 ml causes dizziness, sleepiness and tiredness. Avoid driving or operating machinery if you experience these symptoms.

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Liver

Unsafe

Valpro Injection 5 ml may cause hepatotoxicity (liver damage). Therefore it is not recommended in people with hepatic dysfunction. Please inform your doctor if you have a liver impairment or liver problem.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Valpro Injection 5 ml can be given to children above 2 years if prescribed by the doctor. The dose will be adjusted by the doctor depending upon the child's body weight. Valpro Injection 5 ml should be used with extreme caution in children below 2 years as it might cause hepatotoxicity (liver damage).

Country of origin

India

Manufacturer/Marketer address

Mauza Ogli, Suketi Road, Kala Amb, Dist Sirmour, H.P
Other Info - VAL0560

Author Details

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FAQs

Valpro Injection 5 ml belongs to the group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, it is also used to treat bipolar disorder.
Valpro Injection 5 ml decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizures episodes.
Valpro Injection 5 ml is used to treat bipolar disorder by increasing the amount of a chemical substance called GABA; this helps in blocking the nerve transmission across the brain and provides a calming effect.
Valpro Injection 5 ml may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a proper diet and exercising regularly.
Valpro Injection 5 ml may cause hepatotoxicity (liver damage). Consult your doctor if you experience symptoms such as weakness, facial swelling, vomiting, malaise (general discomfort), lethargy (lack of energy or enthusiasm), and anorexia (eating disorder). Serum liver tests before starting Valpro Injection 5 ml and at regular intervals for at least six months are advised.
Valpro Injection 5 ml should not be administered to women of child-bearing age unless it is essential to manage her condition. Women of child-bearing age must use effective contraception whilst on treatment with Valpro Injection 5 ml.

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